Characterizing Emerging Canine H3 Influenza Viruses.

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned

Creating a culture of political giving

Financial contributions by individuals to political candidates and parties are a critically important, yet largely overlooked mode of political participation. To date, no one has examined the effects of campaign finance laws on the likelihood of individual contributions. This work does just that, and finds that campaign finance regimes have an indirect effect on the likelihood of an individual contribution by an indirect route. Campaign finance laws shape the behavior of the political elite, who in turn rouse citizens into this critical form of political participation

Attitudes toward annual COVID-19 boosters are highly structured by partisan self-identification and trust in government: Evidence from a longitudinal survey

Objectives: On January 26, 2023, an advisory panel of the United States Food and Drug Administration (FDA) approved a plan for annual vaccination for COVID-19. Given slowing booster uptake in the US, full participation of the public is in doubt. Using data from a longitudinal survey, we investigated the predictors of attitudes toward receiving a COVID-19 booster dose annually. Study design: In February 2023, we completed a panel study of 243 adults from South Dakota who indicated being at least fully vaccinated in a survey conducted in May 2022. Methods: In addition to attitudes on an annual booster, we measured partisan self-identification, trust in government, interpersonal trust, COVID-19 vaccination status, age, gender, education, and income. We examined the effect of changes in COVID-19 vaccination status, and the two trust variables on the willingness to receive a COVID-19 booster dose annually. Results: Logistic regression analysis results showed statistically significant relationships between partisan self-identification, changes in trust in government and COVID-19 vaccination status, age, and the willingness to receive a COVID-19 booster dose annually. Conclusions: The findings underscore the continued relevance of partisan self-identification and trust in government on attitudes toward COVID-19 mitigation measures

Don’t Blame Donors for Ideological Polarization of Political Parties: Ideological Change and Stability Among Political Contributors, 1972-2008

Are campaign contributors to parties and candidates in the United States becoming more ideological? Popular and scholarly accounts suggest that political contributors have disproportionate influence in politics, which suggests an important role for them in shaping party ideology and widening the divide between the major American parties. Using the American National Election Studies (ANES) time series data from 1972 to 2008, we find that although the importance of ideology in motivating donations fluctuates from election to election, there is substantial ideological stability in the donor population over time until 2002 when the proportion of ideological donors sharply increases. Ideological extremism has not become a stronger predictor of contributing money. We conclude that mass donors are not necessarily driving partisan polarization. The implication is that politicians are not so much responsive to ideological extremism as they are strategic in mobilizing ideologues in pursuit of resources and electoral goals

Typologies of Party Finance Systems: A Comparative Study of How Countries Regulate Party Finance and Their Institutional Foundations.

This study catalogues party finance laws in multiple countries and identifies institutional factors that correspond to laws countries choose to adopt. Using data from international sources, we assessed differences in the regulation of money in elections in over 120 states. We classified countries into four types of party finance regimes along two axes: one that reflects regulations affecting party income and a second that reflects rules intended to make party finance more transparent. We found that two institutional factors are associated with the extent of government regulation in financing politics: the type of legal system and the use of proportional representation. Our study provides a new conceptual framework to categorize party finance regimes based on various types of regulations and the linkages between institutional factors and the extent of regulation. This conceptual typology offers a method to assess relationships between finance systems and political outcomes

Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection

Background: Respiratory syncytial virus (RSV) is a leading cause of infant respiratory disease. Infant airway microbiota has been associated with respiratory disease risk and severity. The extent to which interactions between RSV and microbiota occur in the airway, and their impact on respiratory disease susceptibility and severity, are unknown. Methods: We carried out 16S rRNA microbiota profiling of infants in the first year of life from (1) a cross-sectional cohort of 89 RSV-infected infants sampled during illness and 102 matched healthy controls, and (2) a matched longitudinal cohort of 12 infants who developed RSV infection and 12 who did not, sampled before, during, and after infection. Results: We identified 12 taxa significantly associated with RSV infection. All 12 taxa were differentially abundant during infection, with 8 associated with disease severity. Nasal microbiota composition was more discriminative of healthy vs infected than of disease severity. Conclusions: Our findings elucidate the chronology of nasal microbiota dysbiosis and suggest an altered developmental trajectory associated with RSV infection. Microbial temporal dynamics reveal indicators of disease risk, correlates of illness and severity, and impact of RSV infection on microbiota composition