Secukinumab in the treatment of psoriasis: patient selection and perspectives.

Secukinumab is a human monoclonal antibody targeting IL-17A that has been approved for three indications: moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. In Phase III clinical trials for each of these three indications, secukinumab has proven to be both highly efficacious and well-tolerated. However, several biologic medications are currently approved for the treatment of moderate-to-severe plaque psoriasis, and many demonstrate excellent efficacy and safety. Due to this wide selection, it is often unclear how to choose biologics for specific patients. Important considerations in biologic selection include clinical efficacy, safety, cost, convenience, onset of action, and management of comorbid disease. This article aims to outline the key considerations in patient selection for the treatment of plaque psoriasis with secukinumab

Hemosuccus Pancreaticus as a Rare Complication of Bariatric Surgery.

Hemosuccus pancreaticus is a rare cause of gastrointestinal bleeding from the duct of Wirsung into the duodenum via the ampulla of Vater. Hemosuccus pancreaticus is difficult to diagnose because the bleeding is usually intermittent, and the clinical findings are often discordant. Patients present with pain, either left upper quadrant or epigastric, and bleeding, which may present as melena, bright red blood per rectum, or even shock, if the hemorrhage is severe. Hemosuccus pancreaticus is usually caused by rupture of a pseudoaneurysm of a peri-pancreatic artery, often the splenic artery, in the setting of pancreatitis; other causes are very rare. In this report, for the first time to our knowledge, we present a case of hemosuccus pancreaticus that occurred as a complication of bariatric surgery

Impacts of Wheat Export Strategies on Market Shares

Marketing, International Relations/Trade,

Clinical Evaluation of Risankizumab-rzaa in the Treatment of Plaque Psoriasis.

Risankizumab-rzaa (Skyrizi®; AbbVie) is a humanized IgG monoclonal antibody directed against interleukin-23p19 (IL-23p19) indicated for the treatment of moderate-to-severe psoriasis in adults who are candidates for systemic therapy or phototherapy. Four pivotal Phase III trials: UltIMMa-1, UltIMMa-2, IMMhance, and IMMvent have demonstrated efficacy and safety in patients with moderate-to-severe plaque psoriasis. This review highlights important findings from these and other clinical trials that have evaluated risankizumab. In addition, we discuss the mechanism of action, pharmacokinetics/pharmacodynamics, dosing recommendations, drug interactions, other potential indications, and ongoing clinical trials

Quantum Phase Transitions beyond the Landau's Paradigm in Sp(4) Spin System

We propose quantum phase transitions beyond the Landau's paradigm of Sp(4) spin Heisenberg models on the triangular and square lattices, motivated by the exact Sp(4)$\simeq$ SO(5) symmetry of spin-3/2 fermionic cold atomic system with only $s-$wave scattering. On the triangular lattice, we study a phase transition between the $\sqrt{3}\times\sqrt{3}$ spin ordered phase and a $Z_2$ spin liquid phase, this phase transition is described by an O(8) sigma model in terms of fractionalized spinon fields, with significant anomalous scaling dimensions of spin order parameters. On the square lattice, we propose a deconfined critical point between the Neel order and the VBS order, which is described by the CP(3) model, and the monopole effect of the compact U(1) gauge field is expected to be suppressed at the critical point.Comment: 6 pages, 3 figure

Single shot ultrafast all optical magnetization switching of ferromagnetic Co/Pt multilayers

In a number of recent experiments, it has been shown that femtosecond laser pulses can control magnetization on picosecond timescales, which is at least an order of magnitude faster compared to conventional magnetization dynamics. Among these demonstrations, one material system (GdFeCo ferromagnetic films) is particularly interesting, as deterministic toggle-switching of the magnetic order has been achieved without the need of any symmetry breaking magnetic field. This phenomenon is often referred to as all optical switching (AOS). However, so far, GdFeCo remains the only material system where such deterministic switching has been observed. When extended to ferromagnetic systems, which are of greater interest in many technological applications, only a partial effect can be achieved, which in turn requires repeated laser pulses for full switching. However, such repeated pulsing is not only energy hungry, it also negates the speed advantage of AOS. Motivated by this problem, we have developed a general method for single-shot, picosecond timescale, complete all optical switching of ferromagnetic materials. We demonstrate that in exchange-coupled layers of Co/Pt and GdFeCo, single shot, switching of the ferromagnetic Co/Pt layer is achieved within 7 picoseconds after irradiation by a femtosecond laser pulse. We believe that this approach will greatly expand the range of materials and applications for ultrafast magnetic switching.Comment: 11 pages, 3 figures, supplementary material

Profile of tildrakizumab-asmn in the treatment of moderate-to-severe plaque psoriasis: evidence to date.

Plaque psoriasis is an immune-mediated skin disease that affects roughly 3% of adults in the United States. Advances over the past 20 years in understanding the immune-mediated pathophysiology of psoriasis have led to the development of targeted biologic therapies for this condition. Currently, biologic medications approved for the treatment of plaque psoriasis include tumor necrosis factor α inhibitors, interleukin (IL)-17 or IL-17 receptor inhibitors, IL-12/23 inhibitors, and IL-23 inhibitors. Tildrakizumab-asmn is a monoclonal antibody that targets the p19 subunit of IL-23 and is approved for use in adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. This article reviews the current pharmacologic, efficacy, and safety data on tildrakizumab-asmn

The role of electron and phonon temperatures in the helicity-independent all-optical switching of GdFeCo

Ultrafast optical heating of the electrons in ferrimagnetic metals can result in all-optical switching (AOS) of the magnetization. Here we report quantitative measurements of the temperature rise of GdFeCo thin films during helicity-independent AOS. Critical switching fluences are obtained as a function of the initial temperature of the sample and for laser pulse durations from 55 fs to 15 ps. We conclude that non-equilibrium phenomena are necessary for helicity-independent AOS, although the peak electron temperature does not play a critical role. Pump-probe time-resolved experiments show that the switching time increases as the pulse duration increases, with 10 ps pulses resulting in switching times of ~sim 13 ps. These results raise new questions about the fundamental mechanism of helicity-independent AOS.Comment: 18 pages, 6 figures and supplementary material

Suzaku Observations of the Circinus galaxy

We report Suzaku observations of the active, Compton-thick Circinus galaxy. Observations were obtained with both the X-ray Imaging spectrometer (XIS) and the Hard X-ray Detector (HXD). Below 10 keV, the nuclear spectrum is dominated by radiation reflected from cold dense gas of high column density, while above 13 keV the radiation is directly transmitted nuclear emission seen through a column density of $~ 4 x 10^{24} cm^-2. In the 0.2--10 keV band, the XIS spectrum is contaminated at 5% level by the brightest off-nuclear source in Circinus (CG X-1), but drops to 1% in the 5-10 keV and is negligible at higher energies. We find no significant evidence for variability in the hard (>12 keV) emission. The Circinus is marginally detected with the HXD/GSO in the 50--100 keV band at 2.5\sigma level. We model the 3-70 keV band XIS+PIN spectra with a four components: the Compton transmitted nuclear emission, the reflected nuclear emission, a soft power law (representing a combination of scattered nuclear emission, extended emission and contamination by sources in the galaxy below a few keV). The hard nuclear power-law is found to have a photon index Gamma_h ~= 1.6, very similar to the soft power-law. The high energy cut-off is E_C ~= 49 keV. These results agree with those from BeppoSax. An extrapolation of this model up to the GSO band shows good agreement with the GSO spectrum and supports our detection of the Circinus up to ~= 100keV.Comment: ApJ accepte