Simulated Analysis of Drought's Impact on Different Cow-Calf Production Systems

Five representative firm level stochastic simulation models were constructed using historical production cost, cattle prices, weather information and scientifically collected production data from the Gundmendson Sandhills Laboratory operated by University of Nebraska. The five hundred iterative results indicate inclusion of crop residual grazing as a viable drought mitigation tool.Drought Mitigation, Firm Level, Residual Grazing, Simulation, Stochastic, Livestock Production/Industries,

Lost: The Crisis Of Jobless and Out Of School Teens and Young Adults In Chicago, Illinois and the U.S.

This report contains compilations and calculations of various employment data for males and females 16 to 24 years old by race/ethnicity from 2005 to 2014, comparing Chicago, Illinois, the U.S. and in some instances, adding Los Angeles and New York. Besides an array of figures and tables, the report contains GIS generated maps that illustrate the relationship between employment data and population distribution by race/ethnicity. A significant contribution of this report is its demonstration that low rates of employment are spatially concentrated in neighborhoods that are also racially segregated. This report clearly highlights that youth employment rates are tied to conditions in neighborhoods and cannot be seen as distinct from what is happening in the neighborhoods themselves. The devastation of unemployment in turn, wreaks havoc on the neighborhood

A comparison of three heuristics to choose the variable ordering for CAD

Cylindrical algebraic decomposition (CAD) is a key tool for problems in real algebraic geometry and beyond. When using CAD there is often a choice over the variable ordering to use, with some problems infeasible in one ordering but simple in another. Here we discuss a recent experiment comparing three heuristics for making this choice on thousands of examples

β-diketonate versus β-ketoiminate:the importance of a ferrocenyl moiety on improving the anticancer potency

Herein we present a library of fully characterized beta-diketonate and beta-ketoiminate compounds that are functionalized with a ferrocenyl moiety. Their cytotoxic potential has been determined by screening against human breast adenocarcinomas (MCF-7 and MDA-MB-231), human colorectal carcinoma p53 wild type (HCT116 p53(+/+)) and normal human prostate (PNT2) cell lines. The ferrocenyl beta-diketonate compounds are more than 18 times more cytotoxic than the ferrocenyl beta-ketoiminate analogues. Against MCF-7, compounds functionalized at the meta position are up to nine times more cytotoxic than when functionalized at the para position. The ferrocenyl beta-diketonate compounds have increased selectivity towards MCF-7 and MDA-MB-231, with several complexes having selectivity index (SI) values that are more than nine times (MCF-7) and more than six times (MDA-MB-231) that of carboplatin. The stability of these compounds in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) has been assessed by NMR spectroscopy and mass spectrometry studies, and the compounds show no oxidation of the iron center from Fe-II to Fe-III. Cytotoxicity screening was performed in both DMSO and DMF, with no significant differences observedin their potency

Glycan Engineering for Cell and Developmental Biology

Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression. Thus, the ability to modulate the structures of glycans on cell surfaces provides a powerful means not only to understand fundamental processes but also to direct activity and elicit desired cellular responses. Here, we describe methods to sculpt glycans on cell surfaces and highlight recent successes in which artificially engineered glycans have been employed to control biological outcomes such as the immune response and stem cell fate

Synthetic probes of glycosaminoglycan function

Glycosaminoglycans (GAGs) participate in many critical biological processes by modulating the activities of a wide range of proteins, including growth factors, chemokines, and viral receptors. Recent studies using synthetic oligosaccharides and glycomimetic polymers have established the importance of specific structural determinants in controlling GAG function. These findings illustrate the power of synthetic molecules to elucidate glycan-mediated signaling events, as well as the prospect of further advancements to understand the roles of GAGs in vivo and explore their therapeutic potential