7,277 research outputs found
Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank
The effect of genetic variation in the male-specific region of the Y chromosome (MSY) on coronary artery disease and cardiovascular risk factors has been disputed. In this study, we systematically assessed the association of MSY genetic variation on these traits using a kin-cohort analysis of family disease history in the largest sample to date. METHODS: We tested 90 MSY haplogroups against coronary artery disease, hypertension, blood pressure, classical lipid levels, and all-cause mortality in up to 152 186 unrelated, genomically British individuals from UK Biobank. Unlike previous studies, we did not adjust for heritable lifestyle factors (to avoid collider bias) and instead adjusted for geographic variables and socioeconomic deprivation, given the link between MSY haplogroups and geography. For family history traits, subject MSY haplogroups were tested against father and mother disease as validation and negative control, respectively. RESULTS: Our models find little evidence for an effect of any MSY haplogroup on cardiovascular risk in participants. Parental models confirm these findings. CONCLUSIONS: Kin-cohort analysis of the Y chromosome uniquely allows for discoveries in subjects to be validated using family history data. Despite our large sample size, improved models, and parental validation, there is little evidence to suggest cardiovascular risk in UK Biobank is influenced by genetic variation in MSY
Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus.
BackgroundThe presence of concomitant Type II diabetic mellitus (T2DM) and depressive symptoms adversely affects individuals with symptomatic heart failure (HF).HypothesisIn presymptomatic stage B HF, this study hypothesized the presence of greater inflammation and depressive symptoms in T2DM as compared to non-T2DM Stage B patients.MethodsThis cross-sectional study examined clinical parameters, inflammatory biomarkers, and depressive symptoms in 349 T2DM and non-T2DM men with asymptomatic stage B HF (mean age 66.4 years ±10.1; range 30-91).ResultsFewer diabetic HF patients had left ventricular (LV) systolic dysfunction (P < .05) although more had LV diastolic dysfunction (P < .001). A higher percentage of T2DM HF patients were taking ACE-inhibitors, beta-blockers, calcium channel blockers, statins, and diuretics (P values < .05). T2DM HF patients had higher circulating levels of interleukin-6 (IL-6) (P < .01), tumor necrosis factor-alpha (P < .01), and soluble ST2 (sST2) (P < .01) and reported more somatic/affective depressive symptoms (Beck Depression Inventory II) (P < .05) but not cognitive/affective depressive symptoms (P = .20). Among all patients, in a multiple regression analysis predicting presence of somatic/affective depressive symptoms, sST2 (P = .026), IL-6 (P = .010), B-type natriuretic peptide (P = .016), and sleep (Pittsburgh Sleep Quality Index [P < .001]) were significant predictors (overall model F = 15.39, P < .001, adjusted R2 = .207).ConclusionsSomatic/affective but not cognitive/affective depressive symptoms are elevated in asymptomatic HF patients with T2DM patients. Linkages with elevated inflammatory and cardiac relevant biomarkers suggest shared pathophysiological mechanisms among T2DM HF patients with somatic depression, and these conditions are responsive to routine interventions, including behavioral. Copyright © 2019 John Wiley & Sons, Ltd
An indoor test methodology for solar-powered wireless sensor networks
Repeatable and accurate tests are important when designing hardware and algorithms for solar-powered wireless sensor networks (WSNs). Since no two days are exactly alike with regard to energy harvesting, tests must be carried out indoors. Solar simulators are traditionally used in replicating the effects of sunlight indoors - however, solar simulators are expensive, have lighting elements that have short lifetimes, and are usually not designed to carry out the types of tests that hardware and algorithm designers require. As a result, hardware and algorithm designers use tests that are inaccurate and not repeatable (both for others and also for the designers themselves). In this article we propose an indoor test methodology which does not rely on solar simulators. The test methodology has its basis in astronomy and photovoltaic (PV) cell design. We present a generic design for a test apparatus which can be used in carrying out the test methodology. We also present a specific design which we use in implementing an actual test apparatus. We test the efficacy of our test apparatus and, to demonstrate the usefulness of the test methodology, perform experiments akin to those required in projects involving solar-powered WSNs. Results of the said tests and experiments demonstrate that the test methodology is an invaluable tool for hardware and algorithm designers working with solar-powered WSNs
Visualizing electrostatic gating effects in two-dimensional heterostructures
The ability to directly observe electronic band structure in modern nanoscale
field-effect devices could transform understanding of their physics and
function. One could, for example, visualize local changes in the electrical and
chemical potentials as a gate voltage is applied. One could also study
intriguing physical phenomena such as electrically induced topological
transitions and many-body spectral reconstructions. Here we show that submicron
angle-resolved photoemission (micro-ARPES) applied to two-dimensional (2D) van
der Waals heterostructures affords this ability. In graphene devices, we
observe a shift of the chemical potential by 0.6 eV across the Dirac point as a
gate voltage is applied. In several 2D semiconductors we see the conduction
band edge appear as electrons accumulate, establishing its energy and momentum,
and observe significant band-gap renormalization at low densities. We also show
that micro-ARPES and optical spectroscopy can be applied to a single device,
allowing rigorous study of the relationship between gate-controlled electronic
and excitonic properties.Comment: Original manuscript with 9 pages with 4 figures in main text, 5 pages
with 4 figures in supplement. Substantially edited manuscript accepted at
Natur
XTE J1946+274 = GRO J1944+26: An Enigmatic Be/X-ray Binary
XTE J1946+274 = GRO J1944+26 is a 15.8 s Be/X-ray pulsar discovered
simultaneously in 1998 September with the Burst and Transient Source Experiment
(BATSE) on the Compton Gamma Ray Observatory (CGRO) and the All-Sky Monitor
(ASM) on the Rossi X-ray Timing Explorer (RXTE). Here we present new results
from BATSE and {\em RXTE} including a pulse timing analysis, spectral analysis,
and evidence for an accretion disk. Our pulse timing analysis yielded an
orbital period of 169.2 days, a moderate eccentricity of 0.33, and implied a
mass function of 9.7 M_sun. We observed evidence for an accretion disk, a
correlation between measured spin-up rate and flux, which was fitted to obtain
a distance estimate of 9.5 +/- 2.9 kpc. XTE J1946+274 remained active from 1998
September - 2001 July, undergoing 13 outbursts that were not locked in orbital
phase. Comparing RXTE PCA observations from the initial bright outburst in 1998
and the last pair of outbursts in 2001, we found energy and intensity dependent
pulse profile variations in both outbursts and hardening spectra with
increasing intensity during the fainter 2001 outbursts. In 2001 July, optical
Halpha observations indicate a density perturbation appeared in the Be disk as
the X-ray outbursts ceased. We propose that the equatorial plane of the Be star
is inclined with respect to the orbital plane in this system and that this
inclination may be a factor in the unusual outburst behavior of the system.Comment: 18 pages, 15 figures, To appear in ApJ v584, Feb 20, 2003 issu
Probabilistic classification of acute myocardial infarction from multiple cardiac markers
Logistic regression and Gaussian mixture model (GMM) classifiers have been trained to estimate the probability of acute myocardial infarction (AMI) in patients based upon the concentrations of a panel of cardiac markers. The panel consists of two new markers, fatty acid binding protein (FABP) and glycogen phosphorylase BB (GPBB), in addition to the traditional cardiac troponin I (cTnI), creatine kinase MB (CKMB) and myoglobin. The effect of using principal component analysis (PCA) and Fisher discriminant analysis (FDA) to preprocess the marker concentrations was also investigated. The need for classifiers to give an accurate estimate of the probability of AMI is argued and three categories of performance measure are described, namely discriminatory ability, sharpness, and reliability. Numerical performance measures for each category are given and applied. The optimum classifier, based solely upon the samples take on admission, was the logistic regression classifier using FDA preprocessing. This gave an accuracy of 0.85 (95% confidence interval: 0.78–0.91) and a normalised Brier score of 0.89. When samples at both admission and a further time, 1–6 h later, were included, the performance increased significantly, showing that logistic regression classifiers can indeed use the information from the five cardiac markers to accurately and reliably estimate the probability AMI
Utilizing x-ray computed tomography for heritage conservation : the case of megalosaurus bucklandii
Of key importance to any cultural institution is the practice of conservation, the method by which specimens at risk of severe degradation or destruction are treated to ensure that they survive into the future. However, surface inspection is often insufficient to properly inform conservators of the best treatment approach, and where there is little to no record of the conservational history of an object it can be difficult to identify exactly what form of conservation has been undertaken. X-Ray Computed Tomography (XCT) grants a way to overcome these issues by allowing conservators to non-destructively investigate the subsurface details of an artefact to provide essential information on condition of a specimen. Here, the potential of this approach is demonstrated using the first XCT scans of the iconic dentary of Megalosaurus bucklandii Mantell, 1827 (1); the first dinosaur ever named and described scientifically. XCT analysis reveals that the degree of repair is less extensive than previously thought and also elucidates two different material types, M1 and M2, thought to be representative of at least two phases of repair. Finally the potential of this approach is further explored, highlighting its importance for conservation practice, identifying forgeries and hoaxes in addition to potential applications in public engagement
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