13,834 research outputs found
Diffusion Approximations for Demographic Inference: DaDi
Models of demographic history (population sizes, migration rates, and divergence times) inferred from genetic data complement archeology and serve as null models in genome scans for selection. Most current inference methods are computationally limited to considering simple models or non-recombining data. We introduce a method based on a diffusion approximation to the joint frequency spectrum of genetic variation between populations. Our implementation, DaDi, can model up to three interacting populations and scales well to genome-wide data. We have applied DaDi to human data from Africa, Europe, and East Asia, building the most complex statistically well-characterized model of human migration out of Africa to date
Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique.
© 2015, The Author(s).Introduction: There is a lack of agreed and established guidelines for the treatment of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). This reflects, in part, the limited evidence-base underpinning the management of AE-IPF. In the absence of high-quality evidence, the aim of this research was to develop a clinician-led consensus statement for the definition, diagnosis and treatment of AE-IPF. Methods: A literature review was conducted to obtain published material on the definition and treatment of AE-IPF. The results of this review were circulated to an online panel of clinicians for review. Statements were then shared with ten expert respiratory clinicians who regularly treat patients with IPF. A Delphi technique was then used to develop a consensus statement for the definition, diagnosis and treatment of AE-IPF. During the first round of review, clinicians rated the clarity of each statement, the extent to which the statement should be included and provided comments. In two subsequent rounds of review, clinicians were provided with the group median inclusion rating for each statement, and any revised wording of statements to aid clarity. Clinicians were asked to repeat the clarity and inclusion ratings for the revised statements. Results: The literature review, online panel discussion, and face-to-face meeting generated 65 statements covering the definition, diagnosis, and management of AE-IPF. Following three rounds of blind review, 90% of clinicians agreed 39 final statements. These final statements included a definition of AE-IPF, approach to diagnosis, and treatment options, specifically: supportive measures, use of anti-microbials, immunosuppressants, anti-coagulants, anti-fibrotic therapy, escalation, transplant management, and long-term management including discharge planning. Conclusion: This clinician-led consensus statement establishes the ‘best practice’ for the management and treatment of AE-IPF based on current knowledge, evidence, and available treatments. Funding: Boehringer Ingelheim Ltd., Bracknell, West Berkshire, UK
Anomalous Radio-Wave Scattering from Interstellar Plasma Structures
This paper considers scattering screens that have arbitrary spatial
variations of scattering strength transverse to the line of sight, including
screens that are spatially well confined, such as disks and filaments. We
calculate the scattered image of a point source and the observed pulse shape of
a scattered impulse. The consequences of screen confinement include: (1) Source
image shapes that are determined by the physical extent of the screen rather
than by the shapes of much-smaller diffracting microirregularities. These
include image elongations and orientations that are frequency dependent. (2)
Variation with frequency of angular broadening that is much weaker than the
trademark \nu^{-2} scaling law (for a cold, unmagnetized plasma), including
frequency-independent cases; and (3) Similar departure of the pulse broadening
time from the usually expected \nu^{-4} scaling law. We briefly discuss
applications that include scattering of pulses from the Crab pulsar by
filaments in the Crab Nebula; image asymmetries from Galactic scattering of the
sources Cyg X-3, Sgr A*, and NGC 6334B; and scattering of background active
galactic nuclei by intervening galaxies. We also address the consequences for
inferences about the shape of the wavenumber spectrum of electron density
irregularities, which depend on scaling laws for the image size and the pulse
broadening. Future low-frequency (< 100 MHz) array observations will also be
strongly affected by the Galactic structure of scattering material. Our
formalism is derived in the context of radio scattering by plasma density
fluctuations. It is also applicable to optical, UV and X-ray scattering by
grains in the interstellar medium.Comment: 21 pages, LaTeX2e with AASTeX-4.0, 6 PostScript figures, accepted by
ApJ, revised version has minor changes to respond to referee comments and
suggestion
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Autonomous systems thermographic NDT of composite structures
Transient thermography is a method used successfully in the evaluation of composite materials and aerospace structures. It has the capacity to deliver both qualitative and quantitative results about hidden defects or features in a composite structure. Aircraft must undergo routine maintenance – inspection to check for any critical damage and thus to ensure its safety. This work aims to address the challenge of NDT automated inspection and improve the defects’ detection by suggesting an autonomous thermographic imaging approach using a UAV (Unmanned Aerial Vehicle) active thermographic system. The concept of active thermography is discussed and presented in the inspection of aircraft CFRP panels along with the mission planning for aerial inspection using the UAV for real time inspection. Results indicate that the suggested approach could significantly reduce the inspection time, cost, and workload, whilst potentially increase the probability of detection of defects on aircraft composites
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Application of NDT thermographic imaging of aerospace structures
This work aims to address the effectiveness and challenges of Non-Destructive Testing (NDT) inspection and improve the detection of defects without causing damage to the material or operator. It focuses on two types of NDT methods; pulsed thermography and vibrothermography. The paper also explores the possibility of performing automated aerial inspection using an unmanned aerial vehicle (UAV) provided with a thermographic imaging system. The concept of active thermography is discussed for inspecting aircraft CFRP panels along with the proposal for performing aerial inspection using the UAV for real time inspection. Static NDT results and the further UAV research indicate that the UAV inspection approach could significantly reduce the inspection time, cost, and workload, whilst potentially increasing the probability of detection
Development of a cometosheath at comet 67P/Churuyumov-Gerasimenko: A case study comparison of Rosetta observations
Context: The ionosphere of a comet is known to deflect the solar wind through
mass loading, but the interaction is dependent on cometary activity. We
investigate the details of this process at comet 67P using the Rosetta Ion
Composition Analyzer. Aims: This study aims to compare the interaction of the
solar wind and cometary ions during two different time periods in the Rosetta
mission. Methods: We compared both the integrated ion moments (density,
velocity, and momentum flux) and the velocity distribution functions for two
days, four months apart. The velocity distribution functions were projected
into a coordinate system dependent on the magnetic field direction and averaged
over three hours. Results: The first case shows highly scattered H+ in both ion
moments and velocity distribution function. The He2+ ions are somewhat
scattered, but less so, and appear more like those of H2O+ pickup ions. The
second case shows characteristic evidence of mass-loading, where the solar wind
species are deflected, but the velocity distribution function is not
significantly changed. Conclusions: The distributions of H+ in the first case,
when compared to He2+ and H2O+ pickup ions, are indicative of a narrow
cometosheath on the scale of the H+ gyroradius. Thus, He2+ and H2O+, with
larger gyroradii, are largely able to pass through this cometosheath. An
examination of the momentum flux tensor suggests that all species in the first
case have a significant non-gyrotropic momentum flux component that is higher
than that of the second mass-loaded case. Mass loading is not a sufficient
explanation for the distribution functions and momentum flux tensor in the
first case, and so we assume this is evidence of bow shock formation.Comment: 14 pages, 9 figures, 3 tables, 2 video
Making markets through digital platforms:Pearson, edu-business, and the (e)valuation of higher education
Roughness-induced critical phenomena in a turbulent flow
I present empirical evidence that turbulent flows are closely analogous to
critical phenomena, from a reanalysis of friction factor measurements in rough
pipes. The data collapse found here corresponds to Widom scaling near critical
points, and implies that a full understanding of turbulence requires explicit
accounting for boundary roughness
An Alternative Interpretation of Recent ARPES Measurements on TiSe2
Recently there has been a renewed interest in the charge density wave
transition of TiSe2, fuelled by the possibility that this transition may be
driven by the formation of an excitonic insulator or even an excitonic
condensate. We show here that the recent ARPES measurements on TiSe2 can also
be interpreted in terms of an alternative scenario, in which the transition is
due to a combination of Jahn-Teller effects and exciton formation. The hybrid
exciton-phonons which cause the CDW formation interpolate between a purely
structural and a purely electronic type of transition. Above the transition
temperature, the electron-phonon coupling becomes ineffective but a finite
mean-field density of excitons remains and gives rise to the observed diffuse
ARPES signals.Comment: 4 pages, 2 figure
Variational quantum Monte Carlo calculations for solid surfaces
Quantum Monte Carlo methods have proven to predict atomic and bulk properties
of light and non-light elements with high accuracy. Here we report on the first
variational quantum Monte Carlo (VMC) calculations for solid surfaces. Taking
the boundary condition for the simulation from a finite layer geometry, the
Hamiltonian, including a nonlocal pseudopotential, is cast in a layer resolved
form and evaluated with a two-dimensional Ewald summation technique. The exact
cancellation of all Jellium contributions to the Hamiltonian is ensured. The
many-body trial wave function consists of a Slater determinant with
parameterized localized orbitals and a Jastrow factor with a common two-body
term plus a new confinement term representing further variational freedom to
take into account the existence of the surface. We present results for the
ideal (110) surface of Galliumarsenide for different system sizes. With the
optimized trial wave function, we determine some properties related to a solid
surface to illustrate that VMC techniques provide standard results under full
inclusion of many-body effects at solid surfaces.Comment: 9 pages with 2 figures (eps) included, Latex 2.09, uses REVTEX style,
submitted to Phys. Rev.
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