Listening to the voices of the fishing people: how fishers make sense of their lives in today's world

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Wind-driven transport of fresh shelf water into the upper 30m of the Labrador Sea

The Labrador Sea is one of a small number of deep convection sites in the North Atlantic that contribute to the meridional overturning circulation. Buoyancy is lost from surface waters during winter, allowing the formation of dense deep water. During the last few decades, mass loss from the Greenland ice sheet has accelerated, releasing freshwater into the high-latitude North Atlantic. This and the enhanced Arctic freshwater export in recent years have the potential to add buoyancy to surface waters, slowing or suppressing convection in the Labrador Sea. However, the impact of freshwater on convection is dependent on whether or not it can escape the shallow, topographically trapped boundary currents encircling the Labrador Sea. Previous studies have estimated the transport of freshwater into the central Labrador Sea by focusing on the role of eddies. Here, we use a Lagrangian approach by tracking particles in a global, eddy-permitting (1∕12°) ocean model to examine where and when freshwater in the surface 30m enters the Labrador Sea basin. We find that 60% of the total freshwater in the top 100m enters the basin in the top 30m along the eastern side. The year-to-year variability in freshwater transport from the shelves to the central Labrador Sea, as found by the model trajectories in the top 30m, is dominated by wind-driven Ekman transport rather than eddies transporting freshwater into the basin along the northeast

Exploration of the experiences of persons in the traumatic spinal cord injury population in relation to chronic pain management

Chronic pain amongst individuals with traumatic and nontraumatic spinal cord injury (SCI) has high prevalence rates, with severe impact on the activities of daily living, mood, sleep and quality of life. This study aimed to explore the experiences and challenges of chronic pain management amongst the traumatic spinal cord injury (TSCI) population in the Western Cape region of South Africa. A qualitative descriptive approach was chosen for the study, in which 13 individuals living with TSCI were purposively recruited and interviewed telephonically. An inductive thematic analytic approach was used. The results indicate ineffectiveness of standard pain management, with a lack of education regarding pain physiology and pain management strategies as well as unbalanced decision-making between clinician and patient. Thus, patients develop coping strategies to survive with pain. Current pain regimes are suboptimal at best, underpinned by the lack of clarity or a mutually agreed plan to mitigate and eradicate pain

A Machine Learning Approach for Physical Activity Recognition in Cystic Fibrosis

This is the final version. Available on open access from Routledge via the DOI in this recordData availability statement: The datasets generated and/or analyzed during the current study are not publicly available due to GDPR regulations and to protect individual privacy but are available from the corresponding author on reasonable request.This study aimed to develop and validate machine learning models to predict intensities in children and adolescents with cystic fibrosis (CF) across different accelerometry brands and placements. Thirty-five children and adolescents with CF (11.6 ± 2.8 yrs; 15 girls) and 28 healthy youth (12.2 ± 2.7 yrs; 16 girls) performed six activities whilst wearing GENEActivs (both wrists) and ActiGraphs GT9X (both wrists and waist). Three supervised learning classifiers (K-Nearest Neighbour, Random Forest and eXtreme Gradient Boosted Decision Tree) were used to identify the input signal pattern for each PA type and intensity, with a 10-fold cross-validation utilized to assess the performance of the classifiers. ActiGraph GT9X on the dominant wrist and waist and GENEActiv on the dominant wrist failed to predict vigorous intensity PA activities. All other models, for activity type and intensities, exceeded 97% accuracy, with a sensitivity and specificity of greater than 95%, irrespective of accelerometer brand, placement or health condition.Cystic Fibrosis Trust U

Common founder effects of hereditary hemochromatosis, Wilson´s disease, the long QT syndrome and autosomal recessive deafness caused by two novel mutations in the WHRN and TMC1 genes.

BACKGROUND: Genealogy and molecular genetic studies of a Swedish river valley population resulted in a large pedigree, showing that the hereditary hemochromatosis (HH) HFE/p.C282Y mutation is inherited with other recessive disorders such as Wilson´s disease (WND), a rare recessive disorder of copper overload. The population also contain individuals with the Swedish long QT syndrome (LQTS1) founder mutation (KCNQ1/p.Y111C) which in homozygotes causes the Jervell & Lange Nielsen syndrome (JLNS) and hearing loss (HL).Aims of the study were to test whether the Swedish long QT founder mutation originated in an ancestral HFE family and if carriers had an increased risk for hemochromatosis (HH), a treatable disorder. We also aimed to identify the pathogenic mutation causing the hearing loss disorder segregating in the pedigree. METHODS: LQTS patients were asked about their ancestry and possible origin in a HH family. They were also offered a predictive testing for the HFE genotype. Church books were screened for families with hearing loss. One HH family had two members with hearing loss, who underwent molecular genetic analysis of the LQTS founder mutation, connexin 26 and thereafter exome sequencing. Another family with hearing loss in repeat generations was also analyzed for connexin 26 and underwent exome sequencing. RESULTS: Of nine LQTS patients studied, four carried a HFE mutation (two p.C282Y, two p.H63D), none was homozygous. Three LQTS patients confirmed origin in a female founder ( b 1694, identical to AJ b 1694, a HFE pedigree member from the Fax river. Her descent of 44 HH families, included also 29 families with hearing loss (HL) suggesting JLNS. Eleven LQTS probands confirmed origin in a second founder couple (b 1614/1605) in which the woman b 1605 was identical to a HFE pedigree member from the Fjällsjö river. In her descent there were not only 64 HH, six WND families, one JLNS, but also 48 hearing loss families. Most hearing loss was non syndromic and caused by founder effects of the late 16th century. One was of Swedish origin carrying the WHRN, c.1977delC, (p.S660Afs*30) mutation, the other was a TMC1(NM_138691),c.1814T>C,(p.L605P) mutation, possibly of Finnish origin. CONCLUSIONS: Deep human HFE genealogies show HFE to be associated with other genetic disorders like Wilson´s disease, LQTS, JLNS, and autosomal recessive hearing loss. Two new homozygous HL mutations in WHRN/p.S660Afs*30 and TMC1/p.L605P were identified,none of them previously reported from Scandinavia. The rarity of JLNS was possibly caused by miscarriage or intrauterine death. Most hearing loss (81.7%) was seen after 1844 when first cousin marriages were permitted. However, only 10 (10.3%) came from 1st cousin unions and only 2 (2.0 %) was born out of wedlock

Bilingual children’s comprehension of code-switching at an uninformative adjective

Bilingual children regularly hear sentences that contain words from both languages, also known as code-switching. Investigating how bilinguals process code-switching is important for understanding bilingual language acquisition, because young bilinguals have been shown to experience processing costs and reduced comprehension when encountering code-switched nouns. Studies have yet to inves-tigate if processing costs are present when children encounter code-switches at other parts of speech within a sentence. The current study examined how 30 young bilinguals (age range: 37 – 48 months) processed sentences with code-switches at an uninformative determiner-adjective pair before the target noun (e.g., “Can you find le bon [the good] duck?) compared to single-language sentences (e.g., “Can you find the good duck?”). Surprisingly, bilingual children accurately identified the target object in both sentence types, contrasting with previous findings that sentences containing code-switching lead to processing difficulties. Indeed, children showed similar (and in some cases, better) comprehension of sentences with a code-switch at an uninformative adjective phrase, relative to single-language sentenc-es. We conclude that functional information conveyed by a code-switch may contribute to bilingual children’s sentence processing