Metabolic Bone Disease in the Bariatric Surgery Patient

Bariatric surgery has proven to be a life-saving measure for some, but for others it has precipitated a plethora of metabolic complications ranging from mild to life-threatening, sometimes to the point of requiring surgical revision. Obesity was previously thought to be bone protective, but this is indeed not the case. Morbidly obese individuals are at risk for metabolic bone disease (MBD) due to chronic vitamin D deficiency, inadequate calcium intake, sedentary lifestyle, chronic dieting, underlying chronic diseases, and the use of certain medications used to treat those diseases. After bariatric surgery, the risk for bone-related problems is even greater, owing to severely restricted intake, malabsorption, poor compliance with prescribed supplements, and dramatic weight loss. Patients presenting for bariatric surgery should be evaluated for MBD and receive appropriate presurgical interventions. Furthermore, every patient who has undergone bariatric surgery should receive meticulous lifetime monitoring, as the risk for developing MBD remains ever present

Percepciones de docentes acerca de las experiencias de desarrollo profesional: una preocupación que continúa

Teachers’ perceptions of professional development experiences related to process, content, and context were explored to better address leadership preparation needs. Teachers responded to the Professional Development Questionnaire, three demographic variables (teaching experience, Title 1 status, and current grade level) pertaining to the individual, and one open-ended comment field. A total of 327 teachers from a large western school district in the United States responded. The findings indicated that there were no significant differences for the three demographic grouping variables. Overall, results revealed low mean values, indicating that teachers disagreed or strongly disagreed with statements related to their professional development experiences. Teachers also indicated that their own building administrators did not value professional development. Finally, teachers’ perceptions of professional development also suggested that professional development topics were irrelevant, and that they were not provided with enough time to integrate topics into their current practice.Se exploraron las percepciones de maestros acerca de las experiencias de desarrollo profesional relacionadas con el proceso, el contenido y el contexto, a fin de responder mejor a las necesidades de preparación para el liderazgo. Maestros respondieron al Cuestionario de Desarrollo Profesional, tres variables de agrupaciones demográficas (experiencia enseñando, estado de Título 1, y nivel de grado actual) pertenecientes al individuo, y un campo de comentarios de composición abierta. Un total de 327 maestros de un distrito escolar grande del occidente de los Estados Unidos respondió. Los resultados revelaron que no había diferencias significativas para las tres variables de agrupación demográfica. En general, los resultados revelaron bajos valores promedios, indicando que los maestros estaban en desacuerdo, o fuertemente en desacuerdo con las declaraciones relacionadas a sus experiencias de desarrollo profesional. Los maestros también indicaron que sus propios administradores no valoraban el desarrollo profesional. Finalmente, las percepciones de los maestros de desarrollo profesional también sugirieron que los temas al respecto eran irrelevantes y que ellos no tenían suficiente tiempo para integrar dichas cuestiones en su práctica cotidiana

The WHOI Moored Array Project 1963-1978 : data directory and bibliography

General information about mooring locations, durations and data gathered by the Moored Array Project (also known as Buoy Group) between late 1963 and 1978 is listed. Also included is a comprehensive list of scientific and technical publications written by the Buoy Group staff.Prepared for the Office of Naval Research under Contract N00014-76-C-0197; NR 083-400 and for the National Science Foundation under Grant OCE 77-19403

Brain Trust: Students for Students: VCU to RPS Mentorship Program

As a public, urban research institution, Virginia Commonwealth University embraces the importance of developing university-community partnerships that generate innovative solutions to societal challenges and prepare engaged citizens of tomorrow. The Students for Students: VCU to RPS Mentorship Program provides a model that will connect current VCU students to current Richmond Public Schools (RPS) students through a formal, multi-year mentorship. The ultimate goal of this program is to support and positively influence RPS students, while providing current VCU students with an opportunity to give back to the community while developing their mentorship skills. The mentoring relationship will seek to motivate RPS sophomores, juniors and seniors to improve school performance, graduate on time, and craft a post-high school path

Fossil Pollen and Insect Evidence for Postglacial Environmental Conditions, Nushagak and Holitna Lowland Regions, Southwest Alaska

This paper discusses the results of pollen and insect analyses of postglacial samples from the Nushagak and Holitna lowlands, southwest Alaska. Although radiocarbon dating control is poor, the samples can be arranged in a relative-age sequence based on stratigraphic occurrence. The fossil pollen data record the regional transition from a late-glacial dry graminoid tundra through the postglacial Birch, Alder, and Spruce zones. The lack of xeric insect species in the early postglacial suggests that the lowlands of southwest Alaska experienced maritime climatic conditions, in contrast to the interior. Rapid climatic warming is subsequently indicated by the fossil insect data, although the arrival of alder in the region postdates 8500 yr BP. There is no evidence for coniferous forest in the Nushagak lowland at any time in the postglacial, although spruce arrived in the Holitna lowland in the mid-postglacial.Key words: pollen analysis, fossil insects, paleoenvironments, postglacial, southwest AlaskaRÉSUMÉ. Cet article traite des résultats d’analyses polliniques et d’insectes d’échantillons postglaciaires venant des basses-terres de Nushagak et d’Holitna, dans le sud-ouest de l’Alaska. Bien que le contrôle de la datation par le radiocarbone soit médiocre, les échantillons peuvent être classés en ordre d’âger elatif, d’après leur occurrence stratigraphique. Les données de pollens fossiles traduisent le passage de la région d’une toundra sèche de graminées datant de la fin de l’époque glaciaire, à des zones postglaciaires de bouleaux, d’aulnes et d’épicéas. L’absence d’espèces d’insectes xérophiles au début du postglaciaire donne à penser que les basses-terres du sud-ouest de l’Alaska ont connu des conditions climatiques maritimes, contrairement à l’intérieur. Les données sur les insectes fossiles permettent donc d’établir qu’il y a eu un réchauffement climatique rapide, bien que l’arrivée de l’aulne dans la région soit postérieure à 8500 ans avant le présent. On n’a pas de preuve de l’existence d’une forêt de coniferes dans la basse-terre de Nushagak à un moment quelconque du postglaciaire, bien que l’épicéa fasse son arrivée dans la basse-terre d’Holitna au milieu du postglaciaire.Mots clés: analyse pollinique, insectes fossiles, paléoenvironnements, postglaciaire, sud-ouest de l’Alask

Using a Trait Approach to Analyze the Impact of Global Information Technology Applications

The objective of this study is to investigate how global IT applications are being used and to develop a means of assessing their impact. Building on the prior work of Palvia (1997), Sethi and King (1994), and Mahmood and Soon (1991), a multi-factor global IT impact model is developed. This model exhibits a high degree of reliability and validity. From a theoretical perspective, this study develops a measurement model that can be used to evaluate the use and impact of IT in a global environment. From a practitioner’s point of view, the study provides a better understanding of the factors that influence the use and impact of global IT applications

Environmental exposure to polychlorinated biphenyls and p,p\u27-DDE and sperm sex-chromosome disomy

Background: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention. Objectives: We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p´-DDE) exposures with sperm sex-chromosome disomy. Methods: We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p´-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters. Results: The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p´-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy. Conclusions: Our findings suggest that exposure to p,p´-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice

Type 1 diabetes (T1D) results from T-cell-mediated autoimmune destruction of pancreatic β cells. Effector T-cell responses emerge early in disease development and expand as disease progresses. Following β-cell destruction, a long-lived T-cell memory is generated that represents a barrier to islet transplantation and other cellular insulin-replacement therapies. Development of effective immunotherapies that control or ablate β-cell destructive effector and memory T-cell responses has the potential to prevent disease progression and recurrence. Targeting antigen expression to antigen-presenting cells inactivates cognate CD8+ effector and memory T-cell responses and has therapeutic potential. Here we investigated this in the context of insulin-specific responses in the non-obese diabetic mouse where genetic immune tolerance defects could impact on therapeutic tolerance induction. Insulin-specific CD8+ memory T cells transferred to mice expressing proinsulin in antigen-presenting cells proliferated in response to transgenically expressed proinsulin and the majority were rapidly deleted. A small proportion of transferred insulin-specific Tmem remained undeleted and these were antigen-unresponsive, exhibited reduced T cell receptor (TCR) expression and H-2Kd/insB15-23 tetramer binding and expressed co-inhibitory molecules. Expression of proinsulin in antigen-presenting cells also abolished the diabetogenic capacity of CD8+ effector T cells. Therefore, destructive insulin-specific CD8+ T cells are effectively inactivated by enforced proinsulin expression despite tolerance defects that exist in diabetes-prone NOD mice. These findings have important implications in developing immunotherapeutic approaches to T1D and other T-cell-mediated autoimmune diseases