Social Support and Well-being: A Quantitative Study of the Effects of Friendship on the Sexual Well-being of Older Adults

poster abstractBackground: Social support has been shown to positively impact various aspects of health across the lifespan, including sexual health and well-being. While past research on sexual well-being has tended to focus on the earlier stages of the life course, notably adolescence and young adulthood, this is a largely ignored area of research past the reproductive stage of life. Current research finds that while social support, from partners, family, and friends alike, has generally positive influences on health in mid to late adulthood, these outcomes are varied in regards to sexual well-being. Objectives: This study aims to (1) assess the role of friend support in the sexual wellbeing of older adults and (2) to explore if physical and mental health are significant mediators of this relationship. Methods: This study uses data from Wave II of the National Social Life, Health, and Aging Project (NSHAP), a longitudinal, population-based study of health and social factors, aiming to understand the well-being of older, community-dwelling adults. Using binary logistic regression, a series of models were created to evaluate whether social support of friends is a significant predictor of sexual well-being in older adults and whether that relationship is reduced with the introduction of each mediator individually. Covariates included age, race, gender, education, partner status, presence of close family members, and sexual functioning. Results: Sixty two percent of older adults are not having sex as much as they would like and 61% feel that their sex life is lacking in quality. Significant correlates of satisfaction of sex frequency include having a romantic partner (OR .209; p<.000), reliable friends (OR 1.366; p=.010) and sexual dysfunction (OR 1.257; p<.000). Significant correlates of quality of sex life included gender (OR .636; p=.001), education (OR 1.136, p=.037), and sexual dysfunction (OR 1.355; p=.000). Neither mental health nor physical health status were significant mediators of the dependent variables. Conclusion: Similar to findings related to sexual well-being and familial support and reliance (Wait and Das 2010), this study showed that having reliable friends actually decreased the likelihood of satisfaction with sex frequency, one important aspect of sexual well-being. While this relationship may be due to friendship being a proxy for romantic relationships, more research is needed to ascertain the cause of this relationship

Diverse Aging and Health Inequality by Race and Ethnicity

Although gerontologists have long embraced the concept of heterogeneity in theories and models of aging, recent research reveals the importance of racial and ethnic diversity on life course processes leading to health inequality. This article examines research on health inequality by race and ethnicity and identifies theoretical and methodological innovations that are transforming the study of health disparities. Drawing from cumulative inequality theory, we propose greater use of life course analysis, more attention to variability within racial and ethnic groups, and better integration of environmental context into the study of accumulation processes leading to health disparities

Does neighborhood disorder predict recovery from mobility limitation? Findings from the Health and Retirement Study

Objective: This research explores whether perceptions of physical neighborhood disorder predict recovery from mobility limitation over a 2-year period and examines whether psychosocial factors (i.e., depressive symptomology and mastery) and physical activity are salient mediators. Method: Using data from the Health and Retirement Study (HRS): Participant Lifestyle Questionnaire (2008-2010), odds ratio estimates of recovery were ascertained using binary logistic regression, and post hoc Sobel tests were conducted to formally assess mediation. Results: Net of demographic characteristics and socioeconomic status, increased neighborhood disorder was associated with lower odds of recovery. However, both psychosocial indicators and physical activity were significant individual partial mediators, which suggest neighborhood disorder influences recovery from physical impairment via psychosocial processes and barriers to physical activity. Discussion: Reducing neighborhood disorder may enhance older residents’ psychosocial well-being and improve participation in physical activity, thus increasing recovery from mobility limitation and preventing subsequent disability

Founders Versus Descendants: Evidence Of The Taiwanese Publicly Traded Firms

This study investigates the performance of founder-controlled firms vis-à-vis firms controlled by founders’ descendants and relatives among Taiwanese publicly traded firms.  After adjusting for size, age, growth potential, financial leverage, and industry effects, we find that the Taiwanese descendant-controlled firms underperform the matching founder-controlled firms.  In searching for the potential reasons, we find that the average board size for the descendant-controlled firms is significantly larger than that of the founder-controlled firms.  In addition, the ratios of family-related supervisors and board members of the descendant-controlled firms are significantly higher than those of the matching founder-controlled firms.  While the significantly larger board size suggests a potential power struggle between the controlling family and the non-family related board members, the stronger family domination in the board of directors and supervisors for the descendant-controlled firms provides room for entrenchment and tunneling.  In light of the absence of large outside blockholders and relatively weaker legal protections, the minority shareholders of Taiwanese firms are dependent upon internal monitoring mechanisms to protect them from the expropriation of the controlling families.  However, our results indicate that family control has undermined the internal monitoring mechanism of the Taiwanese descendant-controlled firms

Diverse Aging and Health Inequality by Race and Ethnicity

Although gerontologists have long embraced the concept of heterogeneity in theories and models of aging, recent research reveals the importance of racial and ethnic diversity on life course processes leading to health inequality. This article examines research on health inequality by race and ethnicity and identifies theoretical and methodological innovations that are transforming the study of health disparities. Drawing from cumulative inequality theory, we propose greater use of life course analysis, more attention to variability within racial and ethnic groups, and better integration of environmental context into the study of accumulation processes leading to health disparities

Avoiding the Major Causes of Death: Does Childhood Misfortune Reduce the Likelihood of Being Disease Free in Later Life?

Objectives: Although previous research reveals the detrimental effects of early misfortune on the development of chronic diseases in later life, few studies have investigated its effects on remaining disease free. This study draws on cumulative inequality theory to investigate whether experiencing childhood misfortune reduces the likelihood of remaining disease free over time. Method: This study utilizes five waves of data from the Health and Retirement Study to test whether five domains of childhood misfortune predict being disease free at baseline (2004) and developing disease over time (2004–2012). Results: Respondents reporting risky parental behaviors during childhood were less likely to be disease free at baseline and had an increased risk of disease onset over time, the latter driven by having a guardian who smoked in combination with more pack-years smoked in adulthood. Furthermore, we find that adult resources, that is wealth, help to mitigate the noxious effects of other misfortunes, notably poor socioeconomic conditions. Discussion: Consistent with cumulative inequality theory, these findings reveal that experiencing multiple types of misfortune during childhood decreases the likelihood of remaining disease free in later life, but engaging in health behaviors, such as physical activity, can help to ameliorate some of the noxious effects of early misfortune

Short-Term Removal of Exercise Impairs Glycemic Control in Older Adults: A Randomized Trial

Postprandial glycemia (PPG) predicts cardiovascular disease, and short-term physical inactivity increases PPG in young, active adults. Whether this occurs in older, active adults who may be more prone to bouts of inactivity is unknown. This study determined if postprandial interstitial glucose (PPIG) was impaired in active older adults following the removal of exercise for 3 days (NOEX) compared to active young adults. In this randomized, crossover study, 11 older (69.1 ± 1.9 years) and 9 young (32.8 ± 1.8 years) habitually active (≥90 min/week of exercise) adults completed 3-days of NOEX and 3-days of normal habitual exercise (EX), separated by ≥1 week. Diet was standardized across phases. Glycemic control (3-day average) was assessed via continuous glucose monitoring during both phases. Significant main effects of age and phase were detected (p \u3c 0.05), but no interaction was found for steps/day (p \u3e 0.05) (old EX: 6283 ± 607, old NOEX: 2380 ± 382 and young EX: 8798 ± 623, young NOEX: 4075 ± 516 steps/day). Significant main effects of age (p = 0.002) and time (p \u3c 0.001) existed for 1-h PPIG, but no effect of phase or interactions was found (p \u3e 0.05). Significant main effects (p \u3c 0.05) of age (old: 114 ± 1 mg/dl, young: 106 ± 1 mg/dl), phase (NOEX: 112 ± 1 mg/dl, EX: 108 ± 1 mg/dl), and time (0 min: 100 ± 2, 30 min: 118 ± 2, 60 min: 116 ± 2, 90 min: 111 ± 2, 120 min: 108 ± 2 mg/dl) in 2-h PPIG were detected, but no interaction was found (p \u3e 0.05). However, only significant main effects of phase (NOEX: 14 ± 1 and EX:12 ± 1, p \u3e 0.05) were found for 24-h blood glucose standard deviation. Older adults appear to have impaired glycemic control compared to young adults and exercise removal impairs glycemic control in both populations. Yet, the impairment in glycemic control with exercise removal is not different between old and young adults

Combined targeting of TGF-beta, EGFR and HER2 suppresses lymphangiogenesis and metastasis in a pancreatic cancer model

Pancreatic ductal adenocarcinomas (PDAC) are aggressive with frequent lymphatic spread. By analysis of data from The Cancer Genome Atlas, we determined that ∼35% of PDACs have a pro-angiogenic gene signature. We now show that the same PDACs exhibit increased expression of lymphangiogenic genes and lymphatic endothelial cell (LEC) markers, and that LEC abundance in human PDACs correlates with endothelial cell microvessel density. Lymphangiogenic genes and LECs are also elevated in murine PDACs arising in the KRC (mutated Kras; deleted RB) and KIC (mutated Kras; deleted INK4a) genetic models. Moreover, pancreatic cancer cells (PCCs) derived from KRC tumors express and secrete high levels of lymphangiogenic factors, including the EGF receptor ligand, amphiregulin. Importantly, TGF-β1 increases lymphangiogenic genes and amphiregulin expression in KRC PCCs but not in murine PCCs that lack SMAD4, and combinatorial targeting of the TGF-β type I receptor (TβRI) with LY2157299 and EGFR/HER2 with lapatanib suppresses tumor growth and metastasis in a syngeneic orthotopic model, and attenuates tumor lymphangiogenesis and angiogenesis while reducing lymphangiogenic genes and amphiregulin and enhancing apoptosis. Therefore, this combination could be beneficial in PDACs with lymphangiogenic or angiogenic gene signatures

The constant-velocity highly collimated outflows of the planetary nebula He 2-90

We present high-dispersion echelle spectroscopic observations and a narrow-band [N II] image of the remarkable jet-like features of He 2-90. They are detected in the echelle spectra in the H-alpha and [N II] lines but not in other nebular lines. The [N II]/H-alpha ratio is uniformly high, ~1. The observed kinematics reveals bipolar collimated outflows in the jet-like features and shows that the southeast (northwest) component expands towards (away from) the observer at a remarkably constant line-of-sight velocity, 26.0+-0.5 km/s. The observed expansion velocity and the opening angle of the jet-like features are used to estimate an inclination angle of ~5 degrees with respect to the sky plane and a space expansion velocity of ~290 km/s. The spectrum of the bright central nebula reveals a profusion of Fe lines and extended wings of the H-alpha line, similar to those seen in symbiotic stars and some young planetary nebulae that are presumed to host a mass-exchanging binary system. If this is the case for He 2-90, the constant velocity and direction of the jets require a very stable dynamic system against precession and warping.Comment: 8 pages (emulate ApJ), 5 figure, 1 tabl