1,474 research outputs found

    Effects of Anisotropy in QED3 from Dyson-Schwinger equations in a box

    Full text link
    We investigate the effect of anisotropies in the fermion velocities of 2+1 dimensional QED on the critical number N_f^c of fermions for dynamical mass generation. Our framework are the Dyson-Schwinger equations for the gauge boson and fermion propagators formulated in a finite volume. In contrast to previous Dyson-Schwinger studies we do not rely on an expansion in small anisotropies but keep the full velocity dependence of fermion equations intact. As result we find sizable variations of N_f^c away from the isotropic point in agreement with other approaches. We discuss the relevance of our findings for models of high-T_c superconductors.Comment: 9 pages, 7 figures, v2: minor changes, typos corrected, version accepted by PR

    New Modulators of the trace amine associated receptor: Meta linked ureas

    Get PDF
    Millions of people suffer from thyroid hormone disorders. However, many more are unaware of their condition. Symptoms of thyroid conditions fall into two basic categories: hyperthyroidism with excessive thyroid hormone (TH) levels and hypothyroidism with lower TH levels. The thyroid gland is responsible for the synthesis and secretion of the (TH), which includes both thyroxine (T4) and triiodothyronine (T3). The predominant TH produced by the thyroid gland is T4, which is the inactive form. Recent studies have shown, that T3 is a metabolite of T4. This typically takes place at the target tissue or in the liver. The active hormone, T3, is then transported into the cell and binds to a thyroid nuclear receptor (TR). Normally, T3 mediated TR activation leads to the control of various biological processes: core body temperature, heart rate and metabolism. This activation process is typically slow ranging anywhere from hours to days. In the case of hyperthyroidism, patients exhibit increases in their core body temperature, heart rate and metabolism. Alternatively, patients with hypothyroidism experience a decrease in these biological processes. Recently, a naturally occurring metabolite, 3-iodothyronamine (T1AM) was discovered to elicit a rapid physiological response in mice. These include a decrease in core body temperature, metabolism and heart rate. T1AM is a potent agonist of an orphan G-protein coupled receptors (GPCR) known as the trace amine-associated receptor (TAAR1). GPCRs are known to mediate rapid cellular responses. If we consider these opposing physiological effects of T1AM and TH it is possible that T1AM and T3 work in conjunction to provide a regulatory mechanism of TH activity including cardiac output, body temperature, and metabolism. Studying this mechanism may lead to a greater understanding of TH biology. Our lab has been interested in developing novel derivatives of T1AM as a means of examining this mechanism. Previously, we have found that incorporating a urea functional group in place of the ether linkage of T1AM has led to significant TAAR1 activation. These derivatives contained a para-linked aromatic system. The goal of this project is to expand on this structure activity relationship by examining a meta-linked aromatic system. Additionally, the length between the two aryl groups will be examined by insert 0 to 4 methylenes. To this end, the five targeted meta-linked ureas were synthesized utilizing a four step synthesis. These compounds now await biological evaluation in the next phase of the project. By achieving a greater understanding of T1AMs role in thyroid hormone biology there may be more opportunities for treatments of patients who are suffering from thyroid hormone disorders. *This scholar and faculty mentor have requested that only an abstract be published

    New Zealandā€™s Performance Based Research Funding (PBRF) model undermines Maori research

    Get PDF
    The Performance Based Research Funding (PBRF) model was instigated in 2002 to increase ā€œthe quality of research through peer assessment and performance indicatorsā€ in New Zealand (Ministry of Education 2002: 17). It is used to allocate funding between universities, departments and researchers according to the putative quality and quantity of their research outputs over the preceding 6 years. PBRF is expected to incentivise improved research excellence and efficiency, and allow government to invest research funds where greatest returns will result. This is potentially a huge gain for Māori. However, ā€œby changing the conditions of knowledge production, research assessment exercises may also alter the shape and direction of disciplines by diverting and channelling researchersā€™ intellectual attention and political engagement, influencing what they study, how they do it, and how they report and writeā€ (Middleton 2009: 194). Indeed, universities repeatedly encourage researchers to focus on activities that will improve their PBRF rankings. We believe that an unintended consequence of PBRF is the creation of significant barriers to increasing the volume, scope and quality of environmental research for Māori

    Understanding how local climatic changes modify the response of biodiversity to land-use changes

    Get PDF
    Anthropogenic changes to Earthā€™s ecosystems are putting global biodiversity under ever-increasing pressure. Land-use and climate change are two of the biggest pressures facing terrestrial species. These environmental changes, however, are not occurring in isolation and, consequently, may interact. One route by which these two pressures could interact is through the local-scale climatic changes that occur due to land-use change. Human-altered land uses are often hotter and drier than natural habitats, which may lead to these land uses (such as agricultural areas) favouring certain species. Moreover, environmental changes do not impact species uniformly across their distributions. Populationsā€™ climatic positions (i.e., how close the environmental climatic conditions populations experience are to their speciesā€™ climatic tolerance limits) have been found to influence populationsā€™ responses to global climate change, but whether they impact responses to land-use change remains unknown. By using three of the most comprehensive assemblage databases to date (the PREDICTS, Living Planet and BioTIME databases), this thesis investigates the impact of local climatic changes on vertebrate responses to land-use changes. I find that human-altered land uses are reshaping communities by favouring species affiliated with more extreme climatic conditions, especially at tropical latitudes. Further, responses differ across species ranges, with populationsā€™ climatic positions influencing abundances within human-altered land uses. In particular, those populations experiencing temperatures closer to their thermal limits are filtered out of human-altered land uses. In addition, population trends were influenced by interactions between land use, habitat loss, climatic position, and climate change. These results are likely, at least in part, due to the local climatic changes ensuing land-use change. Overall, accounting for these local climatic differences between land uses is essential if we are to fully understand the impacts of environmental changes on biodiversity, set up suitable conservation and management plans to mitigate their effects, and minimise future biodiversity loss
    • ā€¦
    corecore