1,184 research outputs found

    A holistic multi-scale approach to using 3D scanning technology in accident reconstruction

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    Three-dimensional scanning and documentation methods are becoming increasingly employed by law enforcement personnel for crime scene and accident scene recording. Three-dimensional documentation of the victim’s body in such cases is also increasingly used as the field of forensic radiology and imaging is expanding rapidly. These scanning technologies enable a more complete and detailed documentation than standard autopsy. This was used to examine a fatal pedestrian-vehicle collision where the pedestrian was killed by a van whilst crossing the road. Two competing scenarios were considered for the vehicle speed calculation: the pedestrian being projected forward by the impact or the pedestrian being carried on the vehicle’s bonnet. In order to assist with this, the impact area of the accident vehicle was scanned using laser surface scanning, the victim was scanned using postmortem CT and micro-CT and the data sets were combined to virtually match features of the vehicle to injuries on the victim. Micro-CT revealed additional injuries not previously detected, lending support to the pedestrian-carry theory

    A Comparison of Measured and Self-Reported Blood Pressure Status among Low-Income Housing Residents in New York City

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    Self-report is widely used to measure hypertension prevalence in population-based studies, but there is little research comparing self-report with measured blood pressure among low-income populations. The objective of this study was to compare self-reported and measured blood pressure status among a sample of low-income housing residents in New York City (n=118). We completed a cross-sectional analysis comparing self-report with measured blood pressure status. We determined the sensitivity, specificity, and positive predictive value (PPV) of each self-report metric. Of the sample, 68.1% was Black, 71.1% had a household income under $25,000/year, and 28.5% did not complete high school. In our study, there was a discrepancy in the prevalence hypertension by self-report (30.5%) versus measurement (39.8%). PPV of self-report was 94.4%. Specificity was 97.2%. Hypertension awareness (sensitivity) was 72.3%. Of individuals not reporting hypertension, 15.9% had measurements in the hypertensive range and 43.9% had measurements in the borderline hypertensive range. Our findings suggest that self-reported and objective measures of hypertension are incongruent among low-income housing residents and may have important implications for population-based research among low-income populations

    Visualizing and Modeling Interior Spaces of Dangerous Structures using Lidar

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    LIght Detection and Ranging (LIDAR) scanning can be used to safely and remotely provide intelligence on the interior of dangerous structures for use by first responders that need to enter these structures. By scanning into structures through windows and other openings or moving the LIDAR scanning into the structure, in both cases carried by a remote controlled robotic crawler, the presence of dangerous items or personnel can be confi rmed or denied. Entry and egress pathways can be determined in advance, and potential hiding/ambush locations identifi ed. This paper describes an integrated system of a robotic crawler and LIDAR scanner. Both the scanner and the robot are wirelessly remote controlled from a single laptop computer. This includes navigation of the crawler with real-time video, self-leveling of the LIDAR platform, and the ability to raise the scanner up to heights of 2.5 m. Multiple scans can be taken from different angles to fi ll in detail and provide more complete coverage. These scans can quickly be registered to each other using user defi ned \u27pick points\u27, creating a single point cloud from multiple scans. Software has been developed to deconstruct the point clouds, and identify specifi c objects in the interior of the structure from the point cloud. Software has been developed to interactively visualize and walk through the modeled structures. Floor plans are automatically generated and a data export facility has been developed. Tests have been conducted on multiple structures, simulating many of the contingencies that a fi rst responder would face

    Ripple Effects of a Minority Leadership Training Program: Beyond its target

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    Chair: Michiko Iwasaki, Ph.D. ([email protected]) – Loyola University Maryland Discussant: Y. Barry Chung, Ph.D. ([email protected]) – Indiana University The APA Commission of Ethnic Minority Recruitment, Retention, and Training in Psychology (2008) pointed out the underrepresentation of minorities in the field of psychology, particularly in leadership positions. In response to the shortage of minority leaders, the Council of National Psychological Associations for the Advancement of Ethnic Minority Interests (CNPAAEMI) initiated a Leadership Development Institute (LDI) in 2012. The major purpose of the LDI was to foster and nurture ongoing leadership development among early career ethnic minority psychologists. This symposium addresses the ripple effects of this leadership development program. Although the LDI aimed to foster leadership development among a cohort of six early-career ethnic minority professionals, the training program had ripple effects that extended well beyond its primary purpose. This symposium draws from a collaborative project – interviewing ethnic minority leaders in psychology – initiated by the LDI fellows that provided unanticipated learning opportunities for both the fellows and students assisting the project. The first presentation, led by a LDI fellow, will delineate the LDI mechanism and discusses the importance of connecting in-group and out-group members in minority leadership. The second presentation, led by racial minority graduate students, will emphasize the significance of empowerment and presence of role models when considering the pipeline of minority leadership development. The final presentation, led by White minority graduate and undergraduate students, will discuss the nature of White privilege at academic institutions as well as their own personal growth. This symposium targets the following sub-themes of the 2014 Counseling Psychology Conference: training context and domestic/international diversity. A past president of the Society of Counseling Psychology will be a discussant. This symposium offers valuable information regarding leadership training mechanisms in order to enhance cultural sensitivity among all individuals in the psychology field regardless of their color, sexual orientation, or professional/academic levels

    The relationship between maternal phenotype and offspring quality: Do older mothers really produce the best offspring?

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    Maternal effects are increasingly recognized as important drivers of population dynamics and determinants of evolutionary trajectories. Recently, there has been a proliferation of studies finding or citing a positive relationship between maternal size/age and offspring size or offspring quality. The relationship between maternal phenotype and offspring size is intriguing in that it is unclear why young mothers should produce offspring of inferior quality or fitness. Here we evaluate the underlying evolutionary pressures that may lead to a maternal size/age-offspring size correlation and consider the likelihood that such a correlation results in a positive relationship between the age or size of mothers and the fitness of their offspring. We find that, while there are a number of reasons why selection may favor the production of larger offspring by larger mothers, this change in size is more likely due to associated changes in the maternal phenotype that affect the offspring size-performance relationship. We did not find evidence that the offspring of older females should have intrinsically higher fitness. When we explored this issue theoretically, the only instance in which smaller mothers produce suboptimal offspring sizes is when a (largely unsupported) constraint on maximum offspring size is introduced into the model. It is clear that larger offspring fare better than smaller offspring when reared in the same environment, but this misses a critical point: different environments elicit selection for different optimal sizes of young. We suggest that caution should be exercised when interpreting the outcome of offspring-size experiments when offspring from different mothers are reared in a common environment, because this approach may remove the source of selection (e.g., reproducing in different context) that induced a shift in offspring size in the first place. It has been suggested that fish stocks should be managed to preserve these older age classes because larger mothers produce offspring with a greater chance of survival and subsequent recruitment. Overall, we suggest that, while there are clear and compelling reasons for preserving older females in exploited populations, there is little theoretical justification or evidence that older mothers produce offspring with higher per capita fitness than do younger mothers

    A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients

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    We developed a computational pipeline (now provided as a resource) for measuring morphological similarity between cortical surface sulci to construct a sulcal phenotype network (SPN) from each magnetic resonance imaging (MRI) scan in an adult cohort (N=34,725; 45-82 years). Networks estimated from pairwise similarities of 40 sulci on 5 morphological metrics comprised two clusters of sulci, represented also by the bipolar distribution of sulci on a linear-to-complex dimension. Linear sulci were more heritable and typically located in unimodal cortex; complex sulci were less heritable and typically located in heteromodal cortex. Aligning these results with an independent fetal brain MRI cohort (N=228; 21-36 gestational weeks), we found that linear sulci formed earlier, and the earliest and latest-forming sulci had the least between-adult variation. Using high-resolution maps of cortical gene expression, we found that linear sulcation is mechanistically underpinned by trans-sulcal gene expression gradients enriched for developmental processes.</p

    Ligand-Receptor Interactions

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    The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems. During the last few years, three main lines of research led to a dramatic improvement of our understanding of these important phenomena. First, combination of genetic engineering and X ray cristallography made available a simultaneous knowledg of the precise structure and affinity of series or related ligand-receptor systems differing by a few well-defined atoms. Second, improvement of computer power and simulation techniques allowed extended exploration of the interaction of realistic macromolecules. Third, simultaneous development of a variety of techniques based on atomic force microscopy, hydrodynamic flow, biomembrane probes, optical tweezers, magnetic fields or flexible transducers yielded direct experimental information of the behavior of single ligand receptor bonds. At the same time, investigation of well defined cellular models raised the interest of biologists to the kinetic and mechanical properties of cell membrane receptors. The aim of this review is to give a description of these advances that benefitted from a largely multidisciplinar approach

    HLA genotyping in the international Type 1 Diabetes Genetics Consortium

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    Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loci in all affected sibling pair and trio families, and cases and controls, recruited from four networks worldwide, for analysis with clinical phenotypes and immunological markers
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