Extended plasticity in commercial-purity zinc

90% rolling-reduction of annealed commercial-purity zinc sheet (grain size 100 - 150 μ) results in the fragmentation of the large grains into, finally, stable micro-grains, 1 - 211 in diameter. The stability of the micro-grains is due to the presence of soluble and insoluble impurities which prevent recrystallization. This micro-grain material is strain-rate sensitive, and elongations of 200% have been obtained at room temperature. Although this as-rolled, 90% reduction zinc sheet is not super-plastic according to the current definition, its behaviour has led to the coining of the phase 'extended plasticity'. Evidence of grain-boundary sliding is found on examination of the surface by scanning electron microscopy, while the examination of thin foils and activation energy measurements support the dynamic softening (recovery) theory; thus, both these mechanisms must be operating, to a greater or less extent, to confer on this material the observe mechanical behaviour. It is finally concluded that it is dangerous to draw conclusions regarding the mechanism of plastic deformation from surface observations alone

Optimal Quantum Circuits for General Two-Qubit Gates

In order to demonstrate non-trivial quantum computations experimentally, such as the synthesis of arbitrary entangled states, it will be useful to understand how to decompose a desired quantum computation into the shortest possible sequence of one-qubit and two-qubit gates. We contribute to this effort by providing a method to construct an optimal quantum circuit for a general two-qubit gate that requires at most 3 CNOT gates and 15 elementary one-qubit gates. Moreover, if the desired two-qubit gate corresponds to a purely real unitary transformation, we provide a construction that requires at most 2 CNOTs and 12 one-qubit gates. We then prove that these constructions are optimal with respect to the family of CNOT, y-rotation, z-rotation, and phase gates.Comment: 6 pages, 8 figures, new title, final journal versio

The role of the charge state of PAHs in ultraviolet extinction

Aims: We explore the relation between charge state of polycyclic aromatic hydrocarbons (PAHs) and extinction curve morphology. Methods: We fit extinction curves with a dust model including core-mantle spherical particles of mixed chemical composition (silicate core, $sp^2$ and $sp^3$ carbonaceous layers), and an additional molecular component. We use exact methods to calculate the extinction due to classical particles and accurate computed absorption spectra of PAHs in different charge states, for the contribution due to the molecular component, along a sample of five rather different lines of sight. Results: A combination of classical dust particles and mixtures of real PAHs satisfactorily matches the observed interstellar extinction curves. Variations of the spectral properties of PAHs in different charge states produce changes consistent with the varying relative strengths of the bump and non-linear far-UV rise.Comment: 5 pages, 3 figures, Astronomy & Astrophysics Letters, in pres

The potential of low-intensity and online interventions for depression in low- and middle-income countries

The World Health Organization (WHO) reports that low- and middle-income countries (LMICs) are confronted with a serious ‘mental health gap’, indicating an enormous disparity between the number of individuals in need of mental health care and the availability of professionals to provide such care (WHO in 2010). Traditional forms of mental health services (i.e. face-to-face, individualised assessments and interventions) are therefore not feasible. We propose three strategies for addressing this mental health gap: delivery of evidence-based, low-intensity interventions by non-specialists, the use of transdiagnostic treatment protocols, and strategic deployment of technology to facilitate access and uptake. We urge researchers from all over the world to conduct feasibility studies and randomised controlled studies on the effect of low-intensity interventions and technology supported (e.g. online) interventions in LMICs, preferably using an active control condition as comparison, to ensure we disseminate effective treatments in LMICs

Molecules, ices and astronomy

Molecules in interstellar gas and in interstellar ices play a fundamental role in astronomy. However, the formation of the simplest molecule, molecular hydrogen, is still not fully understood. Similarly, although interstellar ice analogues have received much attention in the laboratory, the evolution of ices in the interstellar medium still requires further study. At UCL we have developed two separate experiments to address these issues and explore the following questions: How is H formed on dust-grain surfaces? What is the budget between internal, kinetic and surface energies in the formation process? What are the astronomical consequences of these results? For ices, we ask: How do molecules desorb from pure and from mixed ices in regions warmed by newly formed stars? What can molecules released from ices tell us about the star-formation process? We put our results in the context of other laboratory work and we describe their application to current problems in astronomy

Strain monitoring of tapestries: results of a three-year research project

The outcomes of an interdisciplinary research project between conservators and engineers investigating the strain experienced by different areas of a tapestry are described. Two techniques were used: full-field monitoring using digital image correlation (DIC) and point measurements using optical fibre sensors. Results showed that it is possible to quantify the global strain across a discrete area of a tapestry using DIC; optical fibre and other sensors were used to validate the DIC. Strain maps created by the DIC depict areas of high and low strain and can be overlaid on images of the tapestry, creating a useful visual tool for conservators, custodians and the general public. DIC identifies areas of high strain not obvious to the naked eye. The equipment can be used in situ in a historic house. In addition the work demonstrated the close relationship between relative humidity and strain

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice

Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibility to colorectal carcinogenesis in vivo. Therefore we investigated the gastric mucosal pathology following H. felis infection in bak-null mice at 6 or 48 wk postinfection. Primary gastric gland culture from bak-null mice was also used to assess the effects of bak deletion on IFN-γ-, TNF-α-, or IL-1β-induced apoptosis. bak-null gastric corpus glands were longer, had increased epithelial Ki-67 expression, and contained fewer parietal and enteroendocrine cells compared with the wild type (wt). In wt mice, bak was expressed at the luminal surface of gastric corpus glands, and this increased 2 wk post-H. felis infection. Apoptotic cell numbers were decreased in bak-null corpus 6 and 48 wk following infection and in primary gland cultures following cytokine administration. Increased gastric epithelial Ki-67 labeling index was observed in C57BL/6 mice after H. felis infection, whereas no such increase was detected in bak-null mice. More severe gastric atrophy was observed in bak-null compared with C57BL/6 mice 6 and 48 wk postinfection, and 76% of bak-null compared with 25% of C57BL/6 mice showed evidence of gastric dysplasia following long-term infection. Collectively, bak therefore regulates gastric epithelial cell apoptosis, proliferation, differentiation, mucosal thickness, and susceptibility to gastric atrophy and dysplasia following H. felis infection

Land use map, Finney County, Kansas

The author has identified the following significant results. Methods for the mapping of land use in agricultural regions are developed and applied to preparation of a land use map of Finney County, Kanas. Six land use categories were identified from an MSS-5 image. These categories are: (1) large field irrigation; (2) small field irrigation; (3) dryland cultivation; (4) rangeland; (5) cultural features; and (6) riverine land. The map is composed of basically homogeneous regions with definable mixtures of the six categories. Each region is bounded by an ocularly evident change in land use