The Alternative Library

Much time and effort has been devoted to designing and developing library Web sites that are easy to navigate by both new students and experienced researchers. In a review of the Southampton Institute Library it was decided that in addition to updating the existing homepage an alternative would be offered. Drawing on theory relating to user interface design,learning styles and creative thinking, an Alternative Library navigation system was added to the more traditional library homepage. The aim was to provide students with a different way to explore and discover the wide range of information resources available by taking a less formal approach to navigation based on the metaphor of physical space and playful exploration

Spreading the Creativity Bug

This paper is a reflection on the authors’ experience of attempting to apply creative thinking techniques in the workplace following attendance at a creative thinking course. It explores the process which involved, initially, the application of the techniques to a specific project, growing awareness of the relevance to other aspects of working life, and finally the realisation of the importance of the creative thinking approach to professional development in general

Road: artists and the stop the M11 link road campaign 1984 - 1994

The project 'Road' is an archive of text, images and oral recordings that document the living history of the 'No M11 Link Road' campaign in East London (Leyton, Leytonstone and Wanstead) from 1984 to 1995, and the people that lived in and visited the area. Road: Acme Artists and the Stop the M11 Link Road Campaign, 1984 – 1994, celebrates and preserves the experiences and thoughts of artists, protesters and the community that lived and worked on the route of the M11 link road

Molecular modelling and drug susceptibilty of the L38 (N) L HIV-1 sub-type C pro-tease

A thesis submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Doctor of Philosophy May 2018Human Immunodeficiency Virus (HIV) is a global concern due to the 36 million people infected worldwide. HIV is genetically diverse consisting of nine subtypes. Subtype C infections predominate in sub-Saharan Africa and this subtype has been under-investigated in comparison to subtype B. Great advances have been made to combat this disease, particularly in South Africa, but drug resistance still remains a concern. HIV protease cleaves the Gag and Gag-Pol polyproteins into their functional forms, making it indispensable to the production of infectious virions. It is, as such, a major drug target. The proteolytic enzyme accumulates mutations associated with drug resistance due to the high replication rate of the virus and the error prone reverse transcriptase. These include mutations in the active site and distal regions. Insertion mutations are rarely incorporated into the hinge region and because of that the effect of these insertions are poorly characterised. The variant protease in this study (L38↑N↑L) contains a double insertion of Asparagine and Leucine at position 38, in the hinge region. For the first time L38↑N↑L protease was successfully overexpressed and purified using a thioredoxin-hexahistidine tag fusion system. Molecular dynamics simulations showed that the flap region of L38↑N↑L was less dynamic than that of a wild-type protease, suggesting a possible mechanism to evade drug binding. Induced-fit docking studies showed that the drugs lopinavir, atazanavir and darunavir do bind L38↑N↑L albeit with reduced hydrophobic contacts and hydrogen bonds. In vitro inhibition studies confirmed that these drugs do bind and inhibit L38↑N↑L. The catalytic efficiency of L38↑N↑L was diminished compared to wild-type, which resulted in reduced replication capacity of the virus. Phenotypic assays showed that L38↑N↑L had reduced susceptibility to darunavir in the presence of a Gag sequence thus confirming that this region does contribute to drug resistance.MT 201

Exploring the Experiences of Underrepresented Students Pursuing Health-Related Graduate or Professional Programs

For many years graduate and professional education programs for the health professions have sought to increase the diversity of their student body to include students from a wider variety of backgrounds. Increasing the diversity of healthcare providers is an essential component of addressing inequities in healthcare. However, despite initiatives to increase racial and ethnic diversity in the health professions, these professions remain largely White and female. Previous researchers have sought to identify the reasons that racial and ethnic minorities are underrepresented in healthcare, and the barriers to persistence and success. Little research exists explaining why men are underrepresented in the healthcare professions, though many healthcare professions have historically been perceived as caregiving professions, and therefore, as “female work.” The purpose of this qualitative study was to add to the existing body of literature on underrepresented pre-health students by exploring the experiences of racial/ethnic minority and male undergraduate students on pre-health paths. This study included 11 participants who self-identified as intending to pursue a graduate or professional healthcare program and as African American, American Indian, Alaskan Native, Hispanic, or male; all were enrolled at one mid-sized, regional university in the southeastern United States. I utilized semi-structured interviews to investigate the experiences of the participants. The themes that emerged among the experiences of pre-health students, included common influences on career choice, what pre-health students believe they need to do to be competitive, challenges, fears and worries about the future, motivation to persist, resources and support utilized, and planning (or lack of planning) for alternate career paths

Advanced Conducting Project

Contents include: After \u27The Thunderer\u27 from Symphony on Themes of John Philip Sousa by Ira Hearshen Angel Band: \u27Suite after Old American Hymn Tunes\u27 by Walter Hartley Children\u27s March: \u27Over the Hills and Far Away\u27 by Percy Aldridge Grainger March: \u27Seventeen come Sunday\u27 from English Folk Song Suite by Ralph Vaughan Williams Rest from Minnesota Portraits by Samuel R. Hazo

Virtually dead: digital public mortuary archaeology

Over recent decades, the ethics, politics and public engagements of mortuary archaeology have received sustained scrutiny, including how we handle, write about and display the archaeological dead. Yet the burgeoning use of digital media to engage different audiences in the archaeology of death and burial have so far escaped attention. This article explores categories and strategies by which digital media create virtual communities engaging with mortuary archaeology. Considering digital public mortuary archaeology (DPMA) as a distinctive theme linking archaeology, mortality and material culture, we discuss blogs, vlogs and Twitter as case studies to illustrate the variety of strategies by which digital media can promote, educate and engage public audiences with archaeological projects and research relating to death and the dead in the human past. The article then explores a selection of key critical concerns regarding how the digital dead are currently portrayed, identifying the need for further investigation and critical reflection on DPMA’s aims, objectives and aspired outcomes.Manchester Metropolitan Universit

Integration of Tools for the Techno-Economic Evaluation of Fixed and Floating Tidal Energy Deployment in the Irish Sea

Marine renewable energy (MRE) development will be crucial to achieve worldwide energy decarbonization. In Europe, 1 GW and 40 GW of ocean energy are set to be developed by 2030 and 2050, respectively. Support is essential if wave and tidal stream arrays are to become more economically viable than they currently are. Four recently developed open-access software tools are used in this study to investigate the critical and expensive elements of potential demonstration and commercial scale tidal projects. The tools have been designed and built to assist users with array configurations, foundation and mooring (F&M) design, operation and maintenance (O&M) strategies, and techno-economic analysis. Demonstration of their use is performed in this study to model scenarios for 2 MW, 10 MW, 40 MW, and 100 MW tidal energy projects employing typical 500 kW fixed and 2 MW floating turbines at the West Anglesey Tidal Demonstration Zone in the Irish Sea. The following metrics are examined: the power output and wake losses of staggered and line configurations; the design and costs of simple gravity-based foundations, gravity-based anchors and the four-chain catenary mooring system of a single turbine; the mean O&M costs and farm availability over the project life; and the breakdown of levelized cost of energy (LCoE) for all eight scenarios to ultimately reveal minimum values of 173 EUR/MWh and 147 EUR/MWh for fixed and floating tidal energy technologies, respectively. The thorough analysis facilitated within these four tools to forecast realistic situations in a specific location can help users design a tidal energy project for an area with considerable potential for commercial scale projects, and thus assist the ocean energy community in promoting and nurturing the sector in the years and decades ahead