Multilateralismus im Hohen Norden: Die Ukrainekrise droht, die Arktisdiplomatie zu versicherheitlichen

Im April dieses Jahres übergab Kanada den Vorsitz des Arktischen Rates an die USA; in der Arktis waren diese bislang kein starker Akteur. Doch gerade jetzt gefährdet die Ukrainekrise die bisher gut funktionierende internationale Zusammenarbeit mit Russland in der Arktis. Gleichzeitig ist angesichts signifikanter umweltpolitischer Herausforderungen und der steigenden wirtschaftlichen Relevanz des Hohen Nordens multilaterale Zusammenarbeit in der Region wichtiger denn je - es gilt sicherzustellen, dass diplomatische Lösungen auch in Zukunft möglich sein werden

Depression and family support in breast cancer patients

MTS, migration and invasion assays in DCIS.COM cells that were previously transduced with scrambled control (Control) or BCL9 KD shRNA. The control cells and BCL9 KD cells were re-transduced with empty vector (EV), BCL9 overexpression (BCL9-OE) and BCL9 KD. BCL9-OE was achieved by transduction using the PCDH-BCL9 (BCL9-OE) acquired from Dr. Carrasco [11]. A Western blot analysis was performed using anti-BCL9, anti-vimentin, anti-E-cadherin antibodies, and anti-β-actin as a loading control. B MTS assay on control cells transduced with EV (control + EV), or BCL9-OE (control + BCL9-OE), BCL9-KD transduced with EV (BCL9 KD + EV), and BCL9-KD transduced with BCL9-OE (BCL9 KD + BCL9-OE). Bar graphs represent mean absorbance at 490 nm normalized to control ± standard error of the mean (SEM) (n = 6). C, D Representative images of the migration and invasion assays. Bar graph represents percent area of cells migrated (left) and invaded (right) under the membrane after 24 h. Invasion and migration were determined by ImageJ analysis of microscopic images per sample, the data are mean values normalized to control ± SEM (n = 3). E TopFlash and FopFlash reporter activity in DCIS.COM transduced as above that were either treated with Wnt3A or control conditioned medium (CM). Data represent mean ± SEM (n = 3, letters indicate statistically significant difference). (PDF 964 kb

Socio-educational support systems for foreigners living in the Czech Republic

The diploma thesis Socio-Educational Support Systems for Foreigners Living in the Czech Republic deals with the topic of integration of foreigners in the Czech Republic. It examines what integration instruments the Czech Republic uses on the governmental and also non- governmental level. It is focused on foreigner's experience with NGOs' integration services in Prague and according to this experience it analyzes if supply meets demand. The theoretical part deals with the topic of integration in general and the current immigration situation in the Czech Republic. It describes the law relating to foreigners living in the Czech Republic and examines the state integration activities. It also covers the non- governmental sphere of working with migrants. The empirical part of the thesis contains a qualitative research; the main question is if supply meets demand in the field of NGOs' integration services. The research is based on half- structured interviews with foreigners who use NGOs' integration services and with the NGOs' workers. The diploma thesis also contains some recommendations for the NGOs according to the main findings from the research. These recommendations should become a useful instrument for improving the efficiency of working with migrants

A study of emissions from domestic solid-fuel stove combustion in Ireland

Solid-fuel stoves are at the heart of many homes not only in developing nations, but also in developed regions where there is significant deployment of such heating appliances. They are often operated inefficiently and in association with high emission fuels like wood. This leads to disproportionate air pollution contributions. Despite the proliferation of these appliances, an understanding of particulate matter (PM) emissions from these sources remains relatively low. Emissions from five solid fuels are quantified using a “conventional” and an Eco design stove. PM measurements are obtained using both “hot filter” sampling of the raw flue gas, and sampling of cooled, diluted flue gas using an Aerosol Chemical Speciation Monitor and AE33 aethalometer. PM emissions factors (EF) derived from diluted flue gas incorporate light condensable organic compounds; hence they are generally higher than those obtained with “hot filter” sampling, which do not. Overall, the PM EFs ranged from 0.2 to 108.2 g GJ−1 for solid fuels. The PM EF determined for a solid fuel depends strongly on the measurement method employed and on user behavior, and less strongly on secondary air supply and stove type. Kerosene-based firelighters were found to make a disproportionately high contribution to PM emissions. Organic aerosol dominated PM composition for all fuels, constituting 50−65% of PM from bituminous and low-smoke ovoids, and 85−95% from torrefied olive stone (TOS) briquettes, sod peat, and wood logs. Torrefied biomass and low-smoke ovoids were found to yield the lowest PM emissions. Substituting these fuels for smoky coal, peat, and wood could reduce PM2.5 emissions by approximately 63%

Uptake of bosentan and macitentan into human hepatocytes.

<p>ERAs were evaluated either in the absence or presence of the transporter inhibitors rifampicin (40 µM) and cyclosporin A (5 µM). Data presented as mean (±SD) pmol/million cells; n = 4 donors; *P<0.05 for comparisons indicated.</p

Dose-dependent intracellular accumulation of test ERAs in sandwich-cultured human hepatocytes.

<p>Ambrisentan displayed the lowest intracellular accumulation followed by bosentan, sitaxsentan, and macitentan. Data are presented as mean (±SD) micromolar (µM) concentration; n = 3 donors; *P<0.05 vs. corresponding intracellular accumulation value for ambrisentan at the same test concentration.</p

Effect of Ambrisentan, Bosentan, Sitaxsentan, and Macitentan on Hepatic Uptake and Efflux Transporters.

a<p>Data presented as mean ± standard deviation for 3 independent studies performed in duplicate;</p>b<p>Data presented for a single experiment preformed in duplicate;</p>c<p>Data previously reported <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087548#pone.0087548-Ray1" target="_blank">[35]</a>. Ambrisentan, bosentan, and macitentan were tested in concentrations ranging from 0.14–100 µM.</p><p>ND = not determined.</p

d₈-Taurocholate (d₈-TCA) total (A) and cellular (B) accumulation in sandwich-cultured human hepatocytes exposed to ambrisentan, bosentan and macitentan.

<p>Bosentan and macitentan treatment resulted in a dose-dependent reduction in total accumulation of d₈-TCA. Ambrisentan, bosentan and macitentan treatment each resulted in a dose-dependent reduction in cellular accumulation of d₈-TCA. Data presented as mean (±SD) expressed as percent of control treated; n = 3 donors; *P<0.05 bosentan vs. control; # P<0.05 macitentan vs. control.</p

Additional file 3: Table S8. of The dynamics of the metabolism of acetate and bicarbonate associated with use of hemodialysates in the ABChD trial: a phase IV, prospective, single center, single blind, randomized, cross-over, two week investigation

Estimating the Difference between Bicarbonate Dialysate Inflow and Arterial Blood Bicarbonate (mEq/L) at Any Time Point during 240 Minute Dialysis Treatment - Excluding Subjects S010, S015, S017. (DOCX 12 kb