The Unicellular State as a Point Source in a Quantum Biological System.

A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific biologic structure or stage. However, such an epigenomic entity exists and its transforming effects can be understood through the obligatory recapitulation of all eukaryotic lifeforms through a zygotic unicellular phase. This requisite biological conjunction can now be properly assessed as the focal point of reconciliation between biology and quantum phenomena, illustrated by deconvoluting complex physiologic traits back to their unicellular origins

A systematic approach to cancer: evolution beyond selection.

Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition based evolution is suggested as an alternative approach to cancer development and progression in which neoplastic cells of differing karyotypes and cellular lineages are assessed as self-referential agencies with purposive participation within tissue microenvironments. As distinct self-aware entities, neoplastic cells occupy unique participant/observer status within tissue ecologies. In consequence, neoplastic proliferation by clonal lineages is enhanced by the advantaged utilization of ecological resources through flexible re-connection with progenitor evolutionary stages

Association of Cystic Medial Necrosis of the Aorta and Undiagnosed Thyroiditis [Scripta Medica]

We have recently seen two patients with cystic medial necrosis of the aorta. The first patient died of a dissecting aneurysm of the thoracic aorta. At autopsy, classical Hashimoto’s thyroiditis was discovered. The second patient died of a rupture of the ascending aorta. At autopsy, chronic thyroiditis was seen with multiple large germinal center and diffuse fibrosis. Neither patient was clinically suspected of thyroid dysfunction although the second patient had had a partial thyroidectomy in the remote past

LARCRIM user's guide, version 1.0

LARCRIM is a relational database management system (RDBMS) which performs the conventional duties of an RDBMS with the added feature that it can store attributes which consist of arrays or matrices. This makes it particularly valuable for scientific data management. It is accessible as a stand-alone system and through an application program interface. The stand-alone system may be executed in two modes: menu or command. The menu mode prompts the user for the input required to create, update, and/or query the database. The command mode requires the direct input of LARCRIM commands. Although LARCRIM is an update of an old database family, its performance on modern computers is quite satisfactory. LARCRIM is written in FORTRAN 77 and runs under the UNIX operating system. Versions have been released for the following computers: SUN (3 & 4), Convex, IRIS, Hewlett-Packard, CRAY 2 & Y-MP

Rheology and ultrasonic properties of Pt57.5Ni5.3Cu14.7P22.5 liquid

The equilibrium and nonequilibrium viscosity and isoconfigurational shear modulus of Pt57.5Ni5.3Cu14.7P22.5 supercooled liquid are evaluated using continuous–strain-rate compression experiments and ultrasonic measurements. By means of a thermodynamically-consistent cooperative shear model, variations in viscosity with both temperature and strain rate are uniquely correlated to the variations in isoconfigurational shear modulus, which leads to an accurate prediction of the liquid fragility and to a good description of the liquid strain-rate sensitivity

Panel discussion

"The Importance of Being Predictable" by John B. Taylor -- "Monetary Policy Under Uncertainty" by Ben S. Bernanke -- "The Importance of Being Predictable" by William PooleMonetary policy

Panel discussion monetary policy modeling: where are we and where should we be going?

Monetary policy ; Inflation (Finance) ; Econometric models

Anelastic to Plastic Transition in Metallic Glass-Forming Liquids

The configurational properties associated with the transition from anelasticity to plasticity in a transiently deforming metallic glass-forming liquid are studied. The data reveal that the underlying transition kinetics for flow can be separated into reversible and irreversible configurational hopping across the liquid energy landscape, identified with beta and alpha relaxation processes, respectively. A critical stress characterizing the transition is recognized as an effective Eshelby “backstress,” revealing a link between the apparent anelasticity and the “confinement stress” of the elastic matrix surrounding the plastic core of a shear transformation zone