Good Riddance to Good Faith?: Deciphering Montana\u27s New Test for Subfacial Challenges to Search Warrant Affidavits

Good Riddance to Good Faith

Good Riddance to Good Faith?: Deciphering Montana\u27s New Test for Subfacial Challenges to Search Warrant Affidavits

Good Riddance to Good Faith

Aerodynamic Mixing Downstream from Line Source of Heat in High-intensity Sound Field

Theory and measurement showed that the heat wake downstream from a line source is displaced by a transverse standing sound wave in a manner similar to a flag waving in a harmonic mode. With a 147 db, 104 cps standing wave, time-mean temperatures were reduced by an order of magnitude except near the displacement-pattern nodal points. The theory showed that a 161 db, 520 cps standing wave considerably increased the mixing in both the time-mean and instantaneous senses

The Effects of Conjoint Behavioral Consultation: Results of a 4-Year Investigation

Conjoint behavioral consultation (CBC) is a structured indirect form of service delivery in which parents, teachers, and other support staff are joined to work together to address the academic, social, or behavioral needs of an individual for whom all parties bear some responsibility. In this article, outcome data from 4 years of federally funded projects in the area of CBC are presented. Thirty graduate students were trained in CBC and were responsible for providing consultation services to parents and teachers of students with disabilities or at risk for academic failure. Consultation clients included 52 students with disabilities such as behavior disorders, attention-deficit hyperactivity disorder, anxiety, and learning disabilities. The primary research objective concerned assessing the efficacy of CBC across home and school settings. Secondarily, a prediction model was investigated based on client age, case complexity, and severity of symptoms. Perception of effectiveness, process acceptability, and consultee satisfaction with consultants was also investigated. Meaningful effect sizes were yielded across home and school settings. A model fitting client age and symptom severity was found to predict school effect size relatively well. Consultees’ perceptions of effectiveness, acceptability of CBC, and satisfaction with consultants were also favorable. Implications of these findings and directions for future research are explored

Greatlakean Substage: A replacement for Valderan Substage in the Lake Michigan basin

New evidence from recent field and seismic investigations in the Lake Michigan basin and in the type areas of the Valders, Two Creeks and Two Rivers deposits necessitates revision of late-glacial ice-front positions, rock- and time-stratigraphic nomenclature and climatic interpretations and deglaciation patterns for the period ca. 14,000-7,000 radiocarbon years B.P. The previously reported and long accepted pattern of deglaciation for the Lake Michigan basin started with a regular retreat from the Lake Border Morainic System, with a minor oscillation marked by the Port Huron moraine(s) and then an extensive Twocreekan deglaciation followed by a major (320 km) post-Twocreekan advance (Valders). However, we now record a major retreat between the times of the Lake Border and Port Huron moraines, followed by a gradual retreat from the Port Huron limit and interrupted by a minor standstill (deposition of Manitowoc Till), a retreat (Twocreekan) and a readvance (Two Rivers Till). No Woodfordian or younger readvance was as extensive as had been the preceding one. This sequence argues for a normal, climatically controlled, progressive deglaciation rather than one interrupted by a major post-Twocreekan (formerly Valderan) surge. This revision appears finally to harmonize the geologic evidence and the palynological record for the Great Lakes region. Our investigations show that Valders Till from which the Valderan Substage was named is late-Woodfordian in age. We propose the term "Greatlakean" as a replacement for the now misleading time-stratigraphic term "Valderan". The type section and the definition of the upper and lower boundaries of the Greatlakean Substage remain the same as those originally proposed for the Valderan Substage but the name is changed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21685/1/0000075.pd

Reply to comments by P. F. Karrow and R. F. Black

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22713/1/0000268.pd

Induction of ventricular arrhythmia by high and low osmolarity ionic and nonionic contrast media

Studies that used prolonged contrast media infusion in canine arteries have generated controversy regarding the arrhythmogenic potential of low osmolarity, nonionic contrast agents. In order to establish the relative safety of these agents in the more typical setting of bolus injections, 4 ml intracoronary bolus injections of Hypaque-76 (n = 54), lohexol-350 (n = 51), and lohexol-140 (n = 51) were given in random order to 10 anesthetized, open-chest dogs undergoing programmed cardiac stimulation. Hemodynamics and electrocardiogram were monitored during stimulation, both during and for 2 minutes after the end of contrast infusion. Occurrence of tachycardia did not differ statistically among agents. Sustained ventricular tachycardia (five episodes) and ventricular fibrillation (seven episodes) occurred only after Hypaque-76 injections (p < 0.002). These results differ from those in studies that use continuous contrast infusion and suggest that low osmolarity nonionic contrast agents are as safe as high osmolarity nonionic contrast media. Both appear safer than ionic contrast material.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27931/1/0000356.pd

Prospective, double-blind, placebo-controlled trial of low-dose amiodarone in patients with severe heart failure and asymptomatic frequent ventricular ectopy

Sudden cardiac death is a common cause of mortality in patients with congestive heart failure. To determine if low-dose amiodarone could reduce sudden death among these patients, a prospective, placebo-controlled, double-blind pilot trial was conducted. One hundred one patients with ejection fractions p = 0.02) and remained low after 6 months, while there was no change in ventricular ectopy among the patients receiving placebo. Despite the reduction in ectopy, there was no improvement in mortality or decrease in the incidence of sudden death. One-year mortality by Kaplan-Meier analysis was 28% in the group receiving amiodarone and 19% in the group receiving placebo (p = NS). One-year mortality in patients with >75% reduction in ventricular ectopy after 1 month of treatment was 31% versus 17% in patients with p = NS). Although the size of the trial and its statistical power do not eliminate the possibility of a significant reduction in mortality with low-dose amiodarone, any effect is likely to be modest, i.e., <25%. Therefore low-dose amiodarone can be safely administered to patients with severely impaired myocardial function and will significantly suppress spontaneous ventricular ectopy. However, despite arrhythmia suppression, low-dose amiodarone may not reduce or may have only a modest effect on the incidence of sudden death in patients with heart failure and asymptomatic ventricular ectopy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29119/1/0000158.pd

Comparing DNA replication programs reveals large timing shifts at centromeres of endocycling cells in maize roots.

Plant cells undergo two types of cell cycles-the mitotic cycle in which DNA replication is coupled to mitosis, and the endocycle in which DNA replication occurs in the absence of cell division. To investigate DNA replication programs in these two types of cell cycles, we pulse labeled intact root tips of maize (Zea mays) with 5-ethynyl-2'-deoxyuridine (EdU) and used flow sorting of nuclei to examine DNA replication timing (RT) during the transition from a mitotic cycle to an endocycle. Comparison of the sequence-based RT profiles showed that most regions of the maize genome replicate at the same time during S phase in mitotic and endocycling cells, despite the need to replicate twice as much DNA in the endocycle and the fact that endocycling is typically associated with cell differentiation. However, regions collectively corresponding to 2% of the genome displayed significant changes in timing between the two types of cell cycles. The majority of these regions are small with a median size of 135 kb, shift to a later RT in the endocycle, and are enriched for genes expressed in the root tip. We found larger regions that shifted RT in centromeres of seven of the ten maize chromosomes. These regions covered the majority of the previously defined functional centromere, which ranged between 1 and 2 Mb in size in the reference genome. They replicate mainly during mid S phase in mitotic cells but primarily in late S phase of the endocycle. In contrast, the immediately adjacent pericentromere sequences are primarily late replicating in both cell cycles. Analysis of CENH3 enrichment levels in 8C vs 2C nuclei suggested that there is only a partial replacement of CENH3 nucleosomes after endocycle replication is complete. The shift to later replication of centromeres and possible reduction in CENH3 enrichment after endocycle replication is consistent with a hypothesis that centromeres are inactivated when their function is no longer needed