94 research outputs found
Human Interaction: A key to managing disruptive behavior in dementia.
The results are part of a larger multi-center, mixed-methods study investigating
the effect of environmental design in managing disruptive behavior in dementia. The
presentation focuses on data from fifteen (15) discussion groups conducted with families
(N = 45) and staff (N= 59) from eight (8) dementia units. Participants were asked to
identify the primary obstacles and facilitators for managing behaviors in long-term care
facilities. Results stress the importance of human interaction and institutional flexibility.
These will be discussed in the context of communication environments and supported by
observational data obtained in five (5) of the units
Differential roles of CCL2 and CCR2 in host defense to coronavirus infection.
The CC chemokine ligand 2 (CCL2, monocyte chemoattractant protein-1) is important in coordinating the immune response following microbial infection by regulating T cell polarization as well as leukocyte migration and accumulation within infected tissues. The present study examines the consequences of mouse hepatitis virus (MHV) infection in mice lacking CCL2 (CCL2(-/-)) in order to determine if signaling by this chemokine is relevant in host defense. Intracerebral infection of CCL2(-/-) mice with MHV did not result in increased morbidity or mortality as compared to either wild type or CCR2(-/-) mice and CCL2(-/-) mice cleared replicating virus from the brain. In contrast, CCR2(-/-) mice displayed an impaired ability to clear virus from the brain that was accompanied by a reduction in the numbers of antigen-specific T cells as compared to both CCL2(-/-) and wild-type mice. The paucity in T cell accumulation within the central nervous system (CNS) of MHV-infected CCR2(-/-) mice was not the result of either a deficiency in antigen-presenting cell (APC) accumulation within draining cervical lymph nodes (CLN) or the generation of virus-specific T cells within this compartment. A similar reduction in macrophage infiltration into the CNS was observed in both CCL2(-/-) and CCR2(-/-) mice when compared to wild-type mice, indicating that both CCL2 and CC chemokine receptor 2 (CCR2) contribute to macrophage migration and accumulation within the CNS following MHV infection. Together, these data demonstrate that CCR2, but not CCL2, is important in host defense following viral infection of the CNS, and CCR2 ligand(s), other than CCL2, participates in generating a protective response
The Fontan epidemic: population projections from the Australia and New Zealand Fontan registry
Background: The number and age demographic of the future Fontan population is unknown
When it is time to hang up the keys: the driving and dementia toolkit – for persons with dementia (PWD) and caregivers – a practical resource
The 1590-1520 Ma Cachoeirinha magmatic arc and its tectonic implications for the Mesoproterozoic SW Amazonian craton crustal evolution
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