20,571 research outputs found
Absorption of Energy at a Metallic Surface due to a Normal Electric Field
The effect of an oscillating electric field normal to a metallic surface may
be described by an effective potential. This induced potential is calculated
using semiclassical variants of the random phase approximation (RPA). Results
are obtained for both ballistic and diffusive electron motion, and for two and
three dimensional systems. The potential induced within the surface causes
absorption of energy. The results are applied to the absorption of radiation by
small metal spheres and discs. They improve upon an earlier treatment which
used the Thomas-Fermi approximation for the effective potential.Comment: 19 pages (Plain TeX), 2 figures, 1 table (Postscript
Identification of novel post-transcriptional features in olfactory receptor family mRNAs.
Olfactory receptor (Olfr) genes comprise the largest gene family in mice. Despite their importance in olfaction, how most Olfr mRNAs are regulated remains unexplored. Using RNA-seq analysis coupled with analysis of pre-existing databases, we found that Olfr mRNAs have several atypical features suggesting that post-transcriptional regulation impacts their expression. First, Olfr mRNAs, as a group, have dramatically higher average AU-content and lower predicted secondary structure than do control mRNAs. Second, Olfr mRNAs have a higher density of AU-rich elements (AREs) in their 3'UTR and upstream open reading frames (uORFs) in their 5 UTR than do control mRNAs. Third, Olfr mRNAs have shorter 3' UTR regions and with fewer predicted miRNA-binding sites. All of these novel properties correlated with higher Olfr expression. We also identified striking differences in the post-transcriptional features of the mRNAs from the two major classes of Olfr genes, a finding consistent with their independent evolutionary origin. Together, our results suggest that the Olfr gene family has encountered unusual selective forces in neural cells that have driven them to acquire unique post-transcriptional regulatory features. In support of this possibility, we found that while Olfr mRNAs are degraded by a deadenylation-dependent mechanism, they are largely protected from this decay in neural lineage cells
Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis
Tuberculosis (TB) remains a global pandemic and drug resistance is rising. Multicellular granuloma formation is the pathological hallmark of Mycobacterium tuberculosis infection. The membrane type 1 matrix metalloproteinase (MT1-MMP or MMP-14) is a collagenase that is key in leukocyte migration and collagen destruction. In patients with TB, induced sputum MT1-MMP mRNA levels were increased 5.1-fold compared with matched controls and correlated positively with extent of lung infiltration on chest radiographs (r = 0.483; p < 0.05). M. tuberculosis infection of primary human monocytes increased MT1-MMP surface expression 31.7-fold and gene expression 24.5-fold. M. tuberculosis-infected monocytes degraded collagen matrix in an MT1-MMP-dependent manner, and MT1-MMP neutralization decreased collagen degradation by 73%. In human TB granulomas, MT1-MMP immunoreactivity was observed in macrophages throughout the granuloma. Monocyte-monocyte networks caused a 17.5-fold increase in MT1-MMP surface expression dependent on p38 MAPK and G protein-coupled receptor-dependent signaling. Monocytes migrating toward agarose beads impregnated with conditioned media from M. tuberculosis-infected monocytes expressed MT1-MMP. Neutralization of MT1-MMP activity decreased this M. tuberculosis network-dependent monocyte migration by 44%. Taken together, we demonstrate that MT1-MMP is central to two key elements of TB pathogenesis, causing collagen degradation and regulating monocyte migration
Higher Order Correlations in Quantum Chaotic Spectra
The statistical properties of the quantum chaotic spectra have been studied,
so far, only up to the second order correlation effects. The numerical as well
as the analytical evidence that random matrix theory can successfully model the
spectral fluctuatations of these systems is available only up to this order.
For a complete understanding of spectral properties it is highly desirable to
study the higher order spectral correlations. This will also inform us about
the limitations of random matrix theory in modelling the properties of quantum
chaotic systems. Our main purpose in this paper is to carry out this study by a
semiclassical calculation for the quantum maps; however results are also valid
for time-independent systems.Comment: Revtex, Four figures (Postscript files), Phys. Rev E (in press
Two tails in NGC 3656, and the major merger origin of shell and minor axis dust lane ellipticals
I report on the discovery of two faint (~ 26.8 Rmag/arcsec^2) tidal tails
around the shell elliptical NGC 3656 (Arp 155). This galaxy had previously been
interpreted as a case of accretion, or minor merger. The two tidal tails are
inconsistent with a minor merger, and point instead to a disk-disk major merger
origin. NGC 3656 extends Toomre's merger sequence toward normal elliptical
galaxies, and hints at a major merger origin for shells and minor-axis dust
lanes. A dwarf galaxy lies at the tip of one of the tidal tails. A prominent
shell, which shows sharp azymuthal color discontinuities, belongs to a rotating
dynamical component of young stars which includes the inner dust lane.Comment: 9 pages, 2 plates, 1 figure, uses aaspp.sty, accepted for publication
in The Astrophysical Journal Letters. Files also available by anonymous ftp
at ftp.iac.es, directory ./pub/balcell
Suppression of Zeno effect for distant detectors
We describe the influence of continuous measurement in a decaying system and
the role of the distance from the detector to the initial location of the
system. The detector is modeled first by a step absorbing potential. For a
close and strong detector, the decay rate of the system is reduced; weaker
detectors do not modify the exponential decay rate but suppress the long-time
deviations above a coupling threshold. Nevertheless, these perturbing effects
of measurement disappear by increasing the distance between the initial state
and the detector, as well as by improving the efficiency of the detector.Comment: 4 pages, 4 figure
Quantum response of weakly chaotic systems
Chaotic systems, that have a small Lyapunov exponent, do not obey the common
random matrix theory predictions within a wide "weak quantum chaos" regime.
This leads to a novel prediction for the rate of heating for cold atoms in
optical billiards with vibrating walls. The Hamiltonian matrix of the driven
system does not look like one from a Gaussian ensemble, but rather it is very
sparse. This sparsity can be characterized by parameters and that
reflect the percentage of large elements, and their connectivity respectively.
For we use a resistor network calculation that has direct relation to the
semi-linear response characteristics of the system.Comment: 7 pages, 5 figures, expanded improved versio
An investigation of bupropion substitution for the interoceptive stimulus effects of nicotine
smoking cessation aid has not been fully elucidated, studies have found that bupropion and nicotine share behavioral and neurophysiological properties suggesting that bupropion might serve as a substitute for nicotine. In fact, bupropion prompts nicotine-appropriate responding in operant and Pavlovian drug discrimination studies with rats. A majority of the literature examining this substitution pattern has been done with an operant paradigm. The present research extended this literature by further characterizing the behavioral and neuropharmacological properties underlying the substitution for a nicotine conditioned stimulus (CS). Examination of the dose-effect function and temporal dynamics of this substitution pattern showed that bupropion (20 mg/kg) produced conditioned responding similar to nicotine (0.4 mg base/kg) (ED50=9.9 mg/kg) at 15 and 30 min after injection and partially substituted 5 and 60 min post-injection. Bupropion produced a pattern of conditioned responding similar to nicotine during a 60-min extinction test. Additionally, it has been hypothesized that bupropion and nicotine have an overlapping dopaminergic mechanism. We tested the effects of bupropion pretreatment the nicotine dose-effect function and the ability of dopamine antagonist to block the substitution of bupropion for nicotine. Pretreatment with doses of bupropion that did not substitute for the nicotine stimulus (5 and 10 mg/kg) did not effect nicotine conditioned responding; pretreatment with 20 mg/kg attenuated nicotine-evoked responding. Pretreatment with the dopamine antagonists SCH-23390 and eticlopride blocked the substitution. Finally, S,S-hydroxybupropion, the major metabolite of bupropion in humans, did not substitute for the nicotine CS
Evaluation of nonmetallic thermal protection materials for the manned space shuttle. Volume 1, task 1: Assessment of technical risks associated with utilization of nonmetallic thermal protection system
Technical problems of design and flight qualification of the proposed classes of surface insulation materials and leading edge materials were reviewed. A screening test plan, a preliminary design data test plan and a design data test plan were outlined. This program defined the apparent critical differences between the surface insulators and the leading edge materials, structuring specialized screening test plans for each of these two classes of materials. Unique testing techniques were shown to be important in evaluating the structural interaction aspects of the surface insulators and a separate task was defined to validate the test plan. In addition, a compilation was made of available information on proposed material (including metallic TPS), previous shuttle programs, pertinent test procedures, and other national programs of merit. This material was collected and summarized in an informally structured workbook
The role of initial state reconstruction in short and long time deviations from exponential decay
We consider the role of the reconstruction of the initial state in the
deviation from exponential decay at short and long times. The long time decay
can be attributed to a wave that was, in a classical-like, probabilistic sense,
fully outside the initial state or the inner region at intermediate times,
i.e., to a completely reconstructed state, whereas the decay during the
exponential regime is due instead to a non-reconstructed wave. At short times
quantum interference between regenerated and non-regenerated paths is
responsible for the deviation from the exponential decay. We may thus conclude
that state reconstruction is a ``consistent history'' for long time deviations
but not for short ones.Comment: 4 pages, 6 figure
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