5 research outputs found
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
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- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
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- Edin Anton
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- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
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- Eriksen Erik
- Ermakova Polina
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- Eugenia Canziani Maria
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- Evans John
- Faber Jens
- Fadda George
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- Fang Yi
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- Forti Adriana
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- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
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- Gallouj Karim
- Galphin Claude
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- Garc\ueda Hern\ue1ndez Pedro
- Garc\ueda Luis
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- George L Bakris
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- Guzm\ue1n Gustavo
- H Boonstra A
- H\uf8ivik Hans
- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
- Haller Hermann
- Halpern Stephen
- Hamamoto Yoshiyuki
- Hamasaki Akihiro
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- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
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- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
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- Hasslacher Christoph
- Hatazaki Masahiro
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- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
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- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Women's Homelessness: International Evidence on Causes, Consequences, Coping and Policies
- Author
- Abraham Chigavazira
- Amanda Geller
- Angela R Fertig
- Ann D&apos
- Ann S Masten
- Ann S Masten
- Anna Zhu
- Barrett Lee
- Barrett Lee
- Barrett Lee
- Bill Edgar
- Bill Mccarthy
- Bonnie D Kerker
- Brendan O&apos
- Brendan O&apos
- Bruce Link
- Busch-Geertsema
- Carole C Upshur
- Chris Chamberlain
- Chris Chamberlain
- Chris Chamberlain
- Christopher Wilderman
- Craig Gundersen
- Cynthia Rocha
- David Ribar
- David Snow
- David Snow
- Deborah Cobb-Clark
- Deborah Cobb-Clark
- Dennis Culhane
- Dirk W Early
- Duncan Mcvicar
- Ellen L Bassuk
- Ellen L Bassuk
- Erika R Lehmann
- Gerhard Glomm
- Guy Johnson
- Guy Johnson
- Guy Johnson
- Guy Johnson
- Guy Johnson
- Igor Popov
- Jana L Jasinski
- Jane K Wagner
- Janice M Molnar
- Joan M Smith
- John C Buckner
- John C Buckner
- John Stretch
- Jung M Park
- Kari C Gentzler
- Kathleen M Ingram
- Kimberly A Tyler
- L Bassuk Ellen
- L Bassuk Ellen
- Lei Lei
- Leonard Pearlin
- Leonard Pearlin
- Leslie Rescorla
- Manuel Munoz
- Marah C Curtis
- Margot B Kushel
- Maryam B Haddad
- Marybeth Shinn
- Marybeth Shinn
- Mason G Haber
- Michael Sosin
- Michael Sosin
- Mikki Meadows-Oliver
- Natalie Waldbrook
- Nicolas Herault
- Norweeta Milburn
- Quigley John
- Randall Kuhn
- Renya Wasson
- Rionach Casey
- Rosanna Scutella
- Roy Grant
- S Hud (u
- Sam Allgood
- Sara Mclanahan
- Sean Kidd
- Sendhil Mullainathan
- Sophie Watson
- Sophie Watson
- Sudhir Venkatesh
- Suzanne L Wenzel
- Suzanne L Wenzel
- Thomas Gould
- Tracy L Dietz
- U K
- U S
- Victoria Banyard
- W Liebow
- William Evans
- Yin-Ling Wong
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
- Bazari Rasha
- Bednarova Jana
- Behnke Thomas
- Bell Alan
- Belle-Isle Jasmin
- Bellotti Sandro
- Belohlavek Jan
- Benczur Bela
- Bennett James
- Berg-Johansen Jan
- Berger Rudolf
- Berrospi Percy
- Bertolet Barry
- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
- Bitters J'Cinda
- Black Robert
- Blagden Mark
- Blanco Antonio
- Blick David
- Bochenek Anna
- Boldueva Svetlana
- Bolshoun David
- Bonansea Teresa C
- Bongo Angelo S
- Bordonava Anselmo
- Borges Joao
- Borisov Borislav
- Bortnick Anna
- Bos Robert
- Botelho Roberto
- Botero Rodrigo
- Botero Rodrigo
- Bott Jochen
- Bouza Manuel
- Boyrazian Hagop
- Brabham David
- Braganza Denise
- Brath Helmut
- Brockmyre Andrew
- Broker Robert
- Brown Christopher
- Buchbinder Maurice
- Bueno Héctor
- Bugan Viliam
- Bula Larysa
- Burgess Lesley
- Busak Ladislav
- Busch Robert
- Busz-Papiez Benita
- Butman Samuel
- Buysschaert Ian
- Byanov Kolyo
- Cabrera Walter
- Calabrò Paolo
- Cantu Elias G
- Cantú Arnulfo G
- Carda Jiri
- Cardona Jose
- Carell Edgar
- Carnero Gabriela
- Carrasco Jose P
- Carrillo Luis V
- Cartwright Simon
- Castillo Armando G
- Cauthen Brett
- Cayla Guillaume
- Cercato Cintia
- Cermak Ondrej
- Cerqueira Maria J
- Ceyhan Ceyhun
- Cha James
- Cha Kwang S
- Chacon Carolina
- Chae In-Ho
- Chae Jei-Keon
- Chag Milan
- Chai Yingru
- Chamnarnphol Noppadol
- Chan Michael
- Chan Shih-Hung
- Chang Kiyuk
- Chang Kuan-Cheng
- Chatrathi Sridhar
- Chavez Carlos
- Chehayeb Raja
- Cheirif Jorge
- Chen Jersey
- Chen Jersey
- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
- Cheung Stephen
- Chhabra Anil
- Chiang Chern
- Chiang Chern-En
- Choi Si-Wan
- Choi Young J
- Chompalova Boryana
- Chorin Ehud
- Chouinard Guy
- Cinteza Mircea
- Clavijo Leonardo
- Clifford Piers
- Cobos Jorge
- Coching Raul M
- Coetzee Kathleen
- Colfer Harry
- Colquhoun David
- Coman Ioan
- Conejeros Carlos
- Constance Christian
- Corbalan Ramon
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- Corder Clinton
- Cordova Fernando
- Cornel Jan H
- Cornel Jan H
- Cortada Jorge B
- Cottin Yves
- Coussement Patrick
- Cox John
- Creteanu Mihai
- Crijns Hendrikus
- Curiac Dan
- Cygler Jerzy
- Cymerman Krzysztof
- Czigány Anna
- Czochra Wojciech
- Czyzycki Mariusz
- D'Agostino Ronald
- D'Urso Michael
- Dada Fredy T
- Dalby Anthony
- Dalby Anthony J
- Danchin Nicolas
- Danchin Nicolas
- Dantzig Jan-Melle
- Darius Harald
- Dart Anthony
- Das Asit
- Dawood Saleem
- de Cosmo Salvatore
- de la Torre Hernández José M
- de Labriolle Axel
- de los Ríos Ibarra Manuel
- de Luca Leonardo
- de Maeseneire Stefan
- de Melker Edwin
- de Nooijer Cornelis
- de Souza Weimar
- Debs-Perez Giselle
- Decoulx Eric
- Dedek Vratislav
- Deering Joseph
- DeGregorio Michele
- Dehghani Payam
- del Blanco Bruno G
- Delforge Marc
- Demchenko Elena
- Desai Pratik
- Deyoung Michael
- Di Pasquale Giuseppe
- Diaz Rafael
- Diaz Rafael
- Dickert Jim
- Didenko Yury
- Dimov Bojidar
- Dincheva Adriana
- Dion Danielle
- Distiller Lawrence
- Dixen Ulrik
- Do Huan
- Dobreanu Viorica
- Doi Tomofumi
- Dolzhenko Maryna
- Domínguez Antonio R
- Dong Xiaolin
- Dor Isaac
- Dorsch Micha
- dos Santos Fabio R
- Dotsenko Sergiy
- Doyle Timothy
- Drelich Grzegorz
- Drexel Heinz
- Drozd Marcin
- Dubreuil Olivier
- Dumas Richard
- Duronto Ernesto
- Dutra Oscar
- Dy Johnny
- Dzhaiani Nino
- Díaz Fernández José F
- Díaz Francisco F
- Eaves William
- Ebenbichler Christoph
- Eder Frank
- Edin Anton
- Egstrup Kenneth
- Eki Yutaka
- El Salah
- El-Amin Omer
- Elamin Omer
- Elbaz Meyer
- Elbl Lubomir
- Eliaschewitz Freddy
- Emerson Ronald
- Ereño Ainhoa R
- Erlinge David
- Ermoshkina Lyudmila
- Eshaghian Shervin
- Estrada José N
- Ezhov Andrey
- Faes Dirk
- Fang Chih
- Fares Issa
- Farsky Stefan
- Fazekas Frantisek
- Feldman Robert
- Fernández Portales Francisco J
- Ferrario Emile
- Ferrario Maurizio
- Ferrolino Arthur
- Figueiredo Estevao
- Figueroa Christian
- Fil Wojciech
- Fillat Angel C
- Fischer Sabine
- Fischer Stuart
- Fließer-Görzer Evelyn
- Fontaine Caroline
- Forgosh Leslie
- Forte Adriana
- Fortes Jose A
- Foster Malcolm
- Foster Michael
- Fourie Nyda
- Fox Kim
- Fox Kim
- Franchetti Marcos
- Frandsen Brad
- Fraser Neil
- Frechette Andre
- French William
- Fresco Claudio
- Fujimoto Kazuteru
- Fujimoto Noritaka
- Fukui Kazuki
- Fullington Douglas
- Fulop Peter
- Furkalo Sergiy
- Földi András
- Förster Andreas
- Fülöp Tibor
- Gadkari Milind
- Gallo Richard
- Galski Thomas
- Galyavich Albert
- Gamba Marco A
- Gandelman Glenn
- Ganim Ricky
- Gaona Raul
- Garas Samer
- García Lledó José A
- García Celso
- García Joel D
- Gardner Timothy
- Gaudet Daniel
- Gazmuri Raul
- Ge Junbo
- Ge Junbo
- Geohas Jeffrey
- Georgiev Svetoslav
- Georgieva Nikolina
- Gibbs Charlotte
- Gigliotti Osvaldo
- Glushko Liubomyr
- Gniot Jacek
- Godoy Armando
- Gogia Harinder
- Gogov Antoni
- Goldberg Cindy
- Goldberg Ronald
- Gomez-Cortes Jose
- Gonzalez Julian
- Gonzalez-Ortiz Elena
- González Juanatey José R
- González Alfonso S
- González Rosa S
- González Vicente B
- Goodfellow Ross
- Gordon Paul
- Gosparini Diego M
- Gossard Denis
- Gosselin Gilbert
- Goto Shinya
- Goto Shinya
- Goto Shinya
- Goube Pascal
- Gowdaiah Prakash
- Graham Bruce
- Graham John
- Gravdal Stein A
- Green Sandy
- Greenberg Gabriel
- Grena Paul
- Greschik István
- Gring Christian
- Grunfeldova Hana
- Guedes Antoine
- Guerra Yamirka D
- Guerrero Diego B
- Guillen Mario
- Guimaraes Fabio
- Guitton Javier
- Gullestad Lars
- Gupta Dinesh
- Guray Umit
- Górska Maria
- Haddad Tariq
- Hage-Korban Elie
- Hagemeier Robert
- Hahn Joo-Yong
- Haisheva Larisa
- Hajek Petr
- Hall Jason
- Halperin Frank
- Hamilton Andrew
- Hammett Christopher
- Hammond Peter
- Handel Franklin
- Handelsman Yehuda
- Hansen Ole
- Hanson Lenita
- Hanusch Ursula
- Hargrove Joeseph
- Haro Jaime M
- Harrington Robert A
- Harrington Robert A
- Hart Randy
- Hart Terence
- Hartikainen Juha
- Hasegawa Toru
- HASH(0x55aa09b7f480)
- Hata Yoshiki
- Haught W H
- Hawa Zafir
- Hazan Lydie
- He Lanjie
- He Yong
- Hearne Steven
- Heath John
- Hedman Anders
- Hegde Vinayak
- Hei Pak
- Held Claes
- Hella Brent
- Henein Sam
- Hennig Dirk
- Henry Sheldon
- Heredia Javier
- Hernandes Mauro
- Higashiue Shinichi
- Hill Laurie
- Himmelmann Anders
- Himmelmann Anders
- Himmelmann Anders
- Hiotis Louis
- Hirohata Atsushi
- Hissa Miguel
- Hoffer Etienne
- Hoffman David
- Hofseth Ola D
- Hollanders Geert
- Holmvang Lene
- Hominal Miguel
- Hong Soon J
- Honkova Michaela
- Hoosen Farzana
- Horak Adrian
- Horibe Eishun
- Horoshko Olha
- Hotchkiss David
- Hou Charles
- Hsia Chien-Hsun
- Hsieh I-Chang
- Huang Wenjun
- Huber Kurt
- Huber Kurt
- Huling Randall
- Huth Mark
- Huynh Thao T
- Hwang Jin-Yong
- Idogaki Akira
- Iliev Nikolay
- Ilieva Katya
- Ing Douglas
- Iosipescu Laura C
- Isaza Daniel
- Ishiki Ryoji
- Istratoaie Octavian
- Iteld Bruce
- Izzo Mark
- Jaafar Feeroz
- Jaffrani Naseem
- Jagielo Ted
- Jain Ashit
- James Stefan K
- James Stefan K
- Jamil-Copley Shahnaz
- Jamriskova Livia
- Jankowski Maciej
- Janssens Luc
- Jaramillo Nicolás
- Jastrzebski Waldemar
- Javier Julian
- Jensen Jens
- Jensen Lisette O
- Jeong Myung H
- Jeong Myung H
- Jerabek Ondrej
- Jeserich Michael
- Jesionowski Pawel
- Jetty Preetham
- Jingo Ahmad
- Johnston Janice
- Johnston Nina
- Jones David
- Juhász Ferenc
- Junior Delcio S
- Jurowiecki Jaroslaw
- Kaczmarek Barbara
- Kadokami Toshiaki
- Kakinoki Shigeo
- Kakuta Tsunekazu
- Kamalov Gadel
- Kanadasi Mehmet
- Kancz Sándor
- Kannarkat Vinod
- Kanorskiy Sergey
- Kantaros Louis
- Kapp Cornelia
- Karageorgiev Dimitar
- Karakolev Venelin
- Karczmarczyk Agnieszka
- Karim Amin
- Karpenko Oleksandr
- Karpov Yuri
- Kasper Joseph
- Kassam Saleem
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kaydashev Igor
- Kazakov Andrei
- Keeling Philip
- Kekki Sakari
- Kelberman Michael
- Kelly Allan
- Kemp Susan
- Kerr Saraiva José F
- Khaira Ajit
- Khan Ahtaram
- Khan Misal
- Khasanov Niyaz
- Khirmanov Vladimir
- Khlevchuk Tatiana
- Khomazyuk Tetyana
- Khovaeva Yaroslava
- Khrustalev Oleg
- Khurana Charanjit
- Khusrawi Alamdar
- Kichura George
- Kim Byung J
- Kim Doo-Il
- Kim Weon
- Kinasz Leszek
- Kinnaman Stephanie
- Kirby William
- Kirschner Róbert
- Király Csaba
- Kiss Robert G
- Kiss Róbert G
- Kiyosue Arihiro
- Kizhakekuttu Tinoy
- Kjærnli Thorbjørn
- Klausmann Gerhard
- Klutstein Marc
- Kobielusz-Gembala Iwona
- Koike Akihiro
- Kolchev Todor
- Koleny Daniel
- Kolodziej Piotr
- Kolomanov Borislav
- Komatsu Sei
- Konczakowski Piotr
- Kondov Rumen
- Kong Xiangqing
- Konieczny Marek
- Konstantinov Vladimir
- Konteva Mariana
- Kontny Frederic
- Koo Bon K
- Kooy Jacobus
- Kopylov Philipp
- Korecki Janusz
- Kormann Adrian
- Korn David
- Korol Marek
- Korpas Denes
- Korzeniak Romuald
- Korányi László
- Kos Pavel
- Kosiborod Mikhail
- Kosiborod Mikhail N
- Kosiborod Mikhail N
- Kosmacheva Elena D
- Kosmicki Douglas
- Kostenko Victor
- Koszek Alina
- Kouz Simon
- Kovář František
- Koziolova Natalia
- Kraiz Igor
- Krajci Peter
- Krakhmalova Olena
- Kravchenko Anatoliy
- Krcova Eva
- Kristensen Dalby
- Kristensen Steen D
- Krolick Merrill
- Kropotina Tatiana
- Kruk Mariusz
- Krzyzagórska Ewa
- Kuanprasert Srun
- Kucera Dusan
- Kuchar Roman
- Kucharczyk-Bauman Izabela
- Kucuk Murathan
- Kuijper Adrianus
- Kulyk Anna
- Kumar Priya
- Kumbhani Dharam
- Kusiak Dawid
- Kuusela Matti
- Kuznetsov Vadim
- Kyrychenko Igor
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- Lang Chim
- Lappegård Knut T
- Larnefeldt Hans
- Laskowska-Derlaga Ewa
- Lawson William
- Le May Michel
- Leaes Paulo
- Ledesma Gilbert
- Lee Denny
- Lee Jung-Hee
- Lee Marcus
- Lee Mu-Jang
- Lee Tsung-Ming
- Lehman Ronald
- Leichter Steven
- Leiter Lawrence A
- Leiter Lawrence A
- Leiter Lawrence A
- Lendel Irina
- Leon Lucio
- Leonsson-Zachrisson Maria
- Lepor Norman
- Lev Eli
- Levchenko Olena
- Levinson Larry
- Lewis Basil
- Lewy-Alterbaum Lorena
- Li Hongwei
- Li Zhanquan
- Liberman Alberto
- Libov Igor
- Lieber Ira
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- Lindholm Carl-Johan
- Linjawi Sultan
- Lisa Libor
- Liu Ming-En
- Liu Zhigang
- Liutkus Joanne F
- Lloret Ramon
- Lo Eric
- Lomakin Nikita
- Londono Juan
- Lopez Gabriel R
- Lorraine Richard
- Losa Beata
- Louwerenburg Hans
- Luckow Anders
- Luengas Carlos
- Lundman Pia
- Luo Ming
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- Lyons Kristopher
- Lysunets Olena
- López Víctor G
- Ma Genshan
- Ma Jianhua
- Ma Ronald
- Macek Vladimir
- Machado Bruno
- Machkova Martina
- MacIsaac Richard
- Madeira Miguel
- Madrigal Jaime C
- Madrzejewski Adam
- Maffei Laura
- Magnitskaya Olga
- Mahal Sharan
- Maheshwari Hiralal
- Maia Lilia
- Majchrzak Piotr
- Makam Sashi
- Makotoko Ellen
- Makukhin Valeriy
- Malecha Jan
- Malinowski Robert
- Maly Jiri
- Manenti Euler
- Mankovsky Boris
- Mannucci Edoardo
- Manrique Helard
- Manshadi Ramin
- Mansour Samer
- Manterola Fernando A
- Mantserova Olga
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- Margáez José G
- Mariankowski Rafal
- Marimon Xavier G
- Marin Jose
- Markov Dimitar
- Markov Valentin
- Maron David
- Martinez Guillermo R
- Marusincova Ivana
- Mascolo Richard
- Maslovskyi Valentyn
- Matiga Generoso
- Matyasek Ivo
- Matyszczak-Toniak Lidia
- Mauro Ciro
- Mayordomo Petra S
- Mazur Stanislaw
- Mazza Giuseppe
- McGuire Darren K
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- McMurray John
- Meadows Charles
- Mediavilla García Juan D
- Medina Felix
- Medina Felix
- Meholick Alan
- Mehta Arvind
- Mehta Rajendra
- Mehta Shamir
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- Mehta Vimal
- Merkely Béla
- Mesa Juan G
- Michalaros Yorghos
- Michalik Daniel
- Michisanti Massimo
- Michishita Ichiro
- Micko Karol
- Miekus Pawel
- Mihov Atanas
- Mihov Lenko
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- Minton Stephen
- Mintz Randy
- Mirek Agnieszka
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- Moiseev Valentin
- Molina Dora
- Mollov Mihail
- Molodtsov Valeriy
- Molter Darron
- Montalescot Gilles
- Montigny Martine
- Morbey Claire
- Moreno Mercé R
- Moriarty Andrew
- Morugova Tatyana
- Motyovszki Ákos
- Moya Jaynier
- Mrozek Vladimir
- Muntaner Juan
- Murillo Abel
- Murphy Clare
- Musial Wlodzimierz
- Muzyk-Osikowicz Marlena
- Myhill Timothy
- Mäkelä Jyrki
- Müller Gábor
- Nadar Venkatesh
- Nadar Venkatesh
- Nagy András C
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- Nakamura Toshihiro
- Nakhle Samer
- Nam Chang-Wook
- Nanji Alykhan
- Napoli Mark
- Nascimento Carlos
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- Nechaeva Galina
- Negron Sandra
- Neuenschwander Fernando
- Nguyen Anh
- Nguyen Hien
- Nguyen Tuan
- Nguyen Tuan Q
- Nicolau José C
- Niedbal-Yahfouf Izabela
- Nielsen Gitte
- Nielsen Henrik
- Nieminen Sakari
- Nierop Pieter
- Niijima Yawara
- Nilsen Dennis
- Nimmegeers Jan
- Nischik Ruth
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- Oral Ivo
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- Yeh Hung-I
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- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk