The effects of sensory integration technique on equilibrium processes in children after prenatal exposure to alcohol

ABSTRACTBackground:The objective of the study was evaluation of sensory integration therapyeffectiveness in children after prenatal exposure to alcohol, on the example of equilibriumprocesses. Material and methods: The study was conducted in 2012 at the Centre ofAdvanced Physiotherapy in Kielce, and covered a group of 20 children aged 4-5 who had ahistory of prenatal exposure to alcohol. The children systematically participated in a one-hourSI therapy session, once a week for the period of 6 months. Results: While evaluating theequilibrium system, 5 trials with clinical observations were performed according to Ayres: theSchilder test, dynamic and static balance, gravitational uncertainty, and postrotary nystagmus.The high effectiveness of SI therapy was confirmed in children subjected to prenatal alcoholexposure based on the example of the equilibrium system. The positive effects of therapywere proved for all the tests applied: the Schilder test (p<0.001), dynamic balance (p<0.001),static balance (p<0.001), gravitational insecurity (p<0.001), and postrotary nystagmus(p<0.05). Conclusions: The sensory integration technique exerts a beneficial effect on thebalance functions of children after prenatal exposure to alcohol

Anthropometric features and postural reactions in children with scoliosis and scoliotic posture

Wilczyński Jacek, Janecka Sylwia, Wilczyński Igor. Anthropometric features and postural reactions in children with scoliosis and scoliotic posture. Journal of Education, Health and Sport. 2017;7(9):320-331. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.997474 http://ojs.ukw.edu.pl/index.php/johs/article/view/4891 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.08.2017. Revised: 10.09.2017. Accepted: 10.09.2017. Anthropometric features and postural reactions in children with scoliosis and scoliotic posture Cechy antropometryczne a reakcje posturalne u dzieci ze skoliozą i postawą skoliotyczną Jacek Wilczyński1, Sylwia Janecka2, Igor Wilczyński3 Department of Neurology, Neurological and Kinesiotherapeutic Rehabilitation, Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce Ph.D. student, Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce Outpatient Rehabilitation Centre for Children, PZOZ in Starachowice SUMMARY Introduction. The aim of the research was to analyze the correlation between the anthropometric features and postural reactions in children with scoliosis and scoliotic posture. Material and method. The study included 28 girls aged 7-18 years old with scoliosis and scoliotic posture. Respondents were selected intentionally. Children attended to the Interschool Centre of Corrective Exercises in Starachowice. Height measurements were made by anthropometer, and the measurement of body weight was made with electronic scale. Those reactions were examined by static-dynamic Tecnobody’s ST 310 Plus Stability System platform. Variables were verified in terms of normal distribution by Shapiro-Wilk test. Depending on the compatibility of variable distributions with normal distribution, and the value of skewness and kurtosis, parametric or non-parametric tests have been used. To determine the correlation between the anthropometric variables and postural reactions the Spearman's rank correlation coefficient has been used. The level of significance was p <0,05. Conclusions. In Romberg’s test with opened eyes (OE), there were no significant correlations between the anthropometric variables and postural reactions. However, in the study with eyes closed (CE), there were significant, inversely proportional correlations between the body height and FBSD, and between the body height and AFBS. Inversely proportional correlations are understandable, because a higher children are generally slightly older, and together with age in children has been observed the reduction of postural reactions (better balance). Analysis of relationships between BMI and postural reactions with eyes closed (CE) showed a significant directly proportional correlations only with Abs AY. Higher values of BMI corresponds to the higher values of Abs AY. Key words: anthropometric features, body posture, scoliosis, scoliotic posture. STRESZCZENIE Wstęp. Celem badań była analiza korelacji między cechami antropometrycznymi a reakcjami posturalnymi u dzieci ze skoliozą i postawą skoliotyczną. Materiał i metoda. Badaniami objęto 28 dziewcząt w wieku 7-18 lat ze skoliozą i postawą skoliotyczną. Do­bór badanych był celowy. Dzieci zapisane były do Międzyszkolnego Ośrodka Gimnastyki Korekcyjnej i Kompensacyjnej w Starachowicach. Pomiary wysokościowe wykonano antropometrem a pomiar masy ciała wagą elektroniczną. Reakcje te badano statyczno-dynamiczną platformą ST 310 Plus Stability System firmy Tecnobody. Zmienne zweryfikowano pod względem normalności rozkładu testem Shapiro-Wilka. W zależności od zgodności rozkładów zmiennych z rozkładem normalnym, oraz wartości skośności i kurtozy, stosowano testy parametryczne lub nieparametryczne. Do określenia korelacji między zmiennymi antropometrycznymi a reakcjami posturalnymi zastosowano współczynnik korelacji rang Spearmana. Jako poziom istotności przy­jęto p<0,05. Wnioski. W teście Romberga z oczami otwartymi (OE) nie wystąpiły istotne korelacje między zmiennymi antropometrycznymi a reakcjami posturalnymi. Natomiast w badaniu z oczami zamkniętymi (CE) wystąpiły istotne odwrotnie proporcjonalne korelacje między wysokością ciała a FBSD oraz między wysokością ciała a AFBS. Korelacje odwrotnie proporcjonalne są zrozumiałe, gdyż wyższe dzieci są ogół nieco starsze a wraz z wiekiem u dzieci obserwuje się obniżanie reakcji posturalnych (lepszą równowagę). Analiza związków między BMI a reakcjami posturalnymi z oczami zamkniętymi (CE) wykazała istotne wprost proporcjonalne korelacje jedynie z Abs AY. Wyższym wartościom BMI odpowiadają wyższe wartości Abs AY. Słowa kluczowe: cechy antropometryczne, postawa ciała, skolioza, postawa skoliotyczna

Pregnancy-related cervical cancer in the material of the Regional Cancer Centre, Łódź, between 2011 and 2014

Introduction. Pregnancy-related cancer is defined as cancer diagnosed during pregnancy or in the first postpartum year. Cervical cancer affects approximately 1 in 1000 pregnant women and is the most common malignancy affecting pregnancy. We retrospectively analysed the clinical outcome and results of treatment in patients with pregnancy-related cervical cancer. Material and methods. We retrospectively analysed the medical records of nine patients with invasive cervical cancer diagnosed during pregnancy and the postpartum period who had been treated in the Regional Oncological Centre, Łódź, between 2011–2014. Results. Three patients with cervical cancer at stage I were diagnosed between the 14th and 17th week of pregnancy afterwards and underwent radical surgery. Two patients with cervical cancer at stage Ib who were diagnosed in the 19th and 24th week of gestation decided to continue pregnancy until the 30th and 32nd week; then a cesarean section combined with radical surgery was performed. In three patients with inoperative cervical cancer diagnosed between the 26th and 28th week of pregnancy, a cesarean section was performed at week 30–32. In one patient cervical cancer at stage IIb was diagnosed during the post-partum period. All patients were treated using intensity-modulated radiotherapy (IMRT) to a total dose of 44 Gy/2Gy, weekly cisplatin (40 mg/m2) concurrent with radiotherapy and brachytherapy. No toxicity was observed. During follow-up, two patients with inoperable cervical cancer were diagnosed with a recurrence 2 and 10 months after treatment, respectively. Conclusions. The management of pregnancy-related cervical cancer is mainly determined by the week of the pregnancy and the stage of the disease at diagnosis, but also by the patient choice. The general condition and follow-up of newborns from pregnancies complicated by cervical cancer are similar to those of newborns arising from non-complicated pregnancies. Treatment toxicity is similar in cases with pregnancy-related cervical cancer and in non-pregnant women with cervical cancer. The major prognostic factor in pregnancy-related cervical cancer remains the stage of the disease at diagnosis

Deviations of the centre of feet pressure in girls with scoliosis and scoliotic posturę

Wilczyński Jacek, Paprocki Michał, Wilczyńska Katarzyna, Wilczyński Igor. Deviations of the centre of feet pressure in girls with scoliosis and scoliotic posturę. Journal of Education, Health and Sport. 2017;7(3):400-413. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.344960 http://ojs.ukw.edu.pl/index.php/johs/article/view/4290 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 12.02.2017. Revised 23.02.2017. Accepted: 28.02.2017. Deviations of the centre of feet pressure in girls with scoliosis and scoliotic posture Wychylenia środka nacisku stóp u dziewcząt ze skoliozą i postawą skoliotyczną Jacek Wilczyński1, Michał Paprocki2, Katarzyna Wilczyńska3, Igor Wilczyński4 Instytut Fizjoterapii, Wydział Lekarski i Nauk o Zdrowiu, Uniwersytet Jana Kochanowskiego w Kielcach Doktorant, Instytut Fizjoterapii, Wydział Lekarski i Nauk o Zdrowiu, Uniwersytet Jana Kochanowskiego w Kielcach Ośrodek Rehabilitacji Dziennej Dla Dorosłych, PZOZ Starachowice Zakład Rehabilitacji Leczniczej, PZOZ w Starachowicach SUMMARY Introduction. The aim of the research was to analyze selected deviations of the centre of feet pressure (COP) in girls with scoliosis and scoliotic posture. Material and methods. 28 girls aged 7-18 years old were involved in the study. Spine research was made by Exhibeon digital radiography. Based on the size of the angle of spinal curvature there were identified scoliotic posture: 1-9° and scoliosis: ≥10°. The deviations of the centre of feet pressure were examined by static-dynamic Tecnobody’s ST 310 Plus Stability System platform. Results. Forward-Backward Standard Deviation Y was from 6,57 with opened eyes (OE) to 7,32 with closed eyes (CE). The difference in Romberg’s Test was 0,75. Medium-Lateral Standard Deviation X was from 3,89 with opened eyes (OE) to 5,54 with closed eyes (CE). The difference in Romberg’s Test was 1,65. Average Forward-Backward Speed Y was from 11,96 with opened eyes (OE) to 17,29 with closed eyes (CE). The difference in Romberg’s Test was 5,33. Average Medium-Lateral Speed X was from 9,96 with opened eyes (OE) to 13,89 with closed eyes (CE). The difference in Romberg’s Test was 3,93. Conclusion. In a study with closed eyes (CE) it has been observed a significant increase of the centre of feet pressure deviations for: Medium-Lateral Standard Deviation X (p=0,022162), Average Forward-Backward Speed Y (p=0,000071) and Average Medium-Lateral Speed X (p=0,000916). Correlation analysis of the centre of feet pressure deviations with age demonstrated an important connections only in case of Medium-Lateral Standard Deviation X (r= -0,38, p=0,043). Key words: Forward-Backward Standard Deviation Y, Medium-Lateral Standard Deviation X, scoliotic postures, idiopathic scoliosis STRESZCZENIE Wstęp. W etiologii skolioz coraz częściej zwraca się uwagę na dyskretne, trudne do zdiagnozowania zmiany neurologiczne. Celem badań była analiza wybranych wychyleń środka nacisku stóp (COP) u dziewcząt ze skoliozą i postawą skoliotyczną. Materiał i metody. Badaniami objęto 28 dziewcząt w wieku 7-18 lat. W badaniach kręgosłupa wykorzystano radiogramy cyfrowe Exhibeon. Na podstawie wielkości kąta skrzywienia kręgosłupa wyodrębniono postawę skoliotyczną: 1-9° i skoliozy: ≥10°. Wychylenia środka nacisku stóp badano statyczno-dynamiczną platformą ST 310 Plus Stability System firmy Tecnobody. Wyniki. Forward-Backward Standard Deviation Y wy­nosiła od 6,57 z oczami otwartymi (OE) do 7,32 z oczami zamkniętymi (CE). Medium-Lateral Standard Deviation X wynosiła od 3,89 z oczami otwartymi (OE) do 5,54 z oczami zamkniętymi (CE). Average Forward-Backward Speed Y wynosiła od 11,96 z oczami otwartymi (OE) do 17,29 z oczami zamkniętymi (CE). Average Medium-Lateral Speed X wynosiła od 9,96 z oczami otwartymi (OE) do 13,89 z oczami zamkniętymi (CE). Wniosek. W badaniu z oczami zamkniętymi (CE) zaobserwowano istotny wzrost wychyleń środka nacisku stóp dla: Medium-Lateral Standard Deviation X (p=0,022162), Average Forward-Backward Speed Y (p=0,000071) i Average Medium-Lateral Speed X (p=0,000916). Analiza korelacji wychyleń środka nacisku stóp z wiekiem wykazała istotne związki w jedynie w przypadku Medium-Lateral Standard Deviation X (r= -0,38, p=0,043). Zależność ta była odwrotnie proporcjonalna. Słowa kluczowe: średnie odchylenie Y, średnie odchylenie X, postawa skoliotyczna, skolioza idiopatyczn

Evaluation of equivalent reactions in women after mastectomy using biodex balance system

Kabała Magdalena, Wilczyński Jacek. Evaluation of equivalent reactions in women after mastectomy using biodex balance system. Journal of Education, Health and Sport. 2017;7(12):565-578. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1133958 http://ojs.ukw.edu.pl/index.php/johs/article/view/5178 https://pbn.nauka.gov.pl/sedno-webapp/works/843238 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.12.2017. Revised: 15.12.2017. Accepted: 29.12.2017. EVALUATION OF EQUIVALENT REACTIONS IN WOMEN AFTER MASTECTOMY USING BIODEX BALANCE SYSTEM OCENA REAKCJI RÓWNOWAŻNYCH U KOBIET PO MASTEKTOMII ZA POMOCĄ URZĄDZENIA BIODEX BALANCE SYSTEM Magdalena Kabała1, Jacek Wilczyński2 1 Ph.D. student, Institute of Physiotherapy, Faculty of Medicine and Health Science, Jan Kochanowski University, Kielce, Poland 2 Head of Department Posturology, Hearing and Balance Rehabilitation, Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce, Poland Corresponding author: Prof. nadzw. dr hab. Jacek Wilczyński Department of Posturology, Hearning and Balance Rehabilitation, Institute of Physiotherapy, Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Al. IX Wieków Kielc 19, 25-317 Kielce, Poland, Tel. 603-703-926, e-mail: jwilczyń[email protected], w.w.w.jacekwilczynski.com.pl Abstract Introduction: Breast cancer is the most commonly diagnosed malignant tumour in women in Poland, as well as in developed countries of the world. The unilateral radical mastectomy may result in disturbance of statics and body balance. Disturbances in body coordination may be associated with unevenly distributed tension of postural muscles between left and right side. Aim of the research: Evaluation of equivalent reactions in women after mastectomy on the basis of posturographic examination. Material and methods: 40 women were provided with the study, including 16 female patients (40%) after right-sided mastectomy and 24 female patients (60%) after left-sided treatment. The average age of respondents was 68.5 years. The Postural Stability Test, as well as Sensor Integration and Balance Test on the Biodex Balance System platform were used to evaluate the equivalent reactions. Research was carried out at the Posturology Laboratory of Physiotherapy Institute of the Jan Kochanowski University in Kielce. Results and conclusions: Mann-Whitney U-test showed a statistically significant relation in the Postural Stability Test in dynamic mode between M/L stability index and the side of carried out mastectomy (p=0.027). Women after right-sided mastectomy mostly had lower parameters in dynamic posture, especially in the frontal plane (M/L). Pearson’s correlation coefficient showed a significant relation between the Postural Stability Test in dynamic mode and the Sensor Integration and Balance Test on a soft open-eye surface (p=0.001). The standing position of examined was characterized by higher leavings in the sagittal plane than in the frontal plane (A/P>M//L). Key words: stability index, mastectomy, Biodex Balance System. Streszczenie Wprowadzenie: Rak piersi jest najczęściej rozpoznawanym nowotworem złośliwym u kobiet w Polsce, jak również w rozwiniętych krajach świata. Konsekwencją zabiegu jednostronnej radykalnej mastektomii może stanowić zaburzenie statyki i równowagi ciała. Zakłócenia koordynacji postawy ciała mogą być związane z nierównomiernie rozłożonym napięciem mięśni posturalnych pomiędzy lewą a prawą stroną. Cel pracy: Ocena reakcji równoważnych u kobiet po mastektomii na postawie badania posturograficznego. Materiał i metody: Badaniami objęto 40 kobiet, w tym 16 pacjentek (40%) po prawostronnej mastektomii i 24 pacjentek (60%) po lewostronnym zabiegu. Średni wiek badanych wynosił 68,5 lat. Do oceny reakcji równoważnych zastosowano Test Stabilności Posturalnej oraz Test Integracji Sensorycznej i Równowagi na platformie Biodex Balance System. Badania wykonano w Laboratorium Posturologii Instytutu Fizjoterapii Uniwersytetu Jana Kochanowskiego w Kielcach. Wyniki i wnioski: Test U Mann-Whitney’a wykazał istotny statystycznie związek w Teście Stabilności Posturalnej w trybie dynamicznym pomiędzy wskaźnikiem stabilności M/L a stroną wykonanej mastektomii (p=0,027). Kobiety po prawostronnej mastektomii posiadały w większości niższe parametry w posturografii dynamicznej, szczególnie w płaszczyźnie czołowej (M/L). Współczynnik korelacji Pearsona wykazał istotną zależność pomiędzy Testem Stabilności Posturalnej w trybie dynamicznym a Testem Integracji Sensorycznej i Równowagi na miękkiej powierzchni przy oczach otwartych (p=0,001). Postawę stojącą badanych charakteryzowały większe wychwiania w płaszczyźnie strzałkowej niż czołowej (A/P>M//L). Słowa kluczowe: wskaźnik stabilności, mastektomia, platforma Biodex Balance System

Anthropometric variables and body composition and SEMG frequency of the spine rectifier in children with scoliosis and scoliotic posture

The purpose of the research was the analysis of the relationship between the anthropometric variables and body composition and frequency of SEMG rectifier of the spine in children with scoliosis and scoliotic attitude. Backbone has been examined by optoelectronic Diers formetric III 4 d. The method photogrammetric video recording of back surface through a process image stereography. Body composition was determined by using the TANITA body composition Analyzer MC 780 m. Analysis of the electromyographical of the spine extensors was performed with the help of 12 channel camera Noraxon TeleMyo DTS. Spine examination method Diers formetric III 4 d has shown in 103 (41%) of children scoliosis. The attitude of scoliotic diagnosed with 141 (56.17%) children. With the correct attitude was 7 (3.0%) children. The most important and significant statistically predictors for model's anthropometric variables, body composition and the frequency of the charger back test in different positions within the Group of scoliosis were the variables BMI (p = 0.01) and percent fat (%) (p = 0.03). Variance explained by the independent variables in the model adopted is 40% of the total variation (R ^ 2 = 0.40), indicating a small adjustment to the data, however, anticipated the level of statistical significance (p = 0.001) have been met, and also received good the value of the test statistic F = 3.33. In the group the basics of scoliotic the mass of fat (p = 0.01). The model was explained only in 26% (R ^ 2 = 0.26), which is low, but anticipated the level of statistical significance (p = 0.01) was also met, and also received the appropriate statistical test value F = 5.10. She has a substantial dependency between certain variables to the anthropometric and body composition and frequency of SEMG rectifier of the spine in children with scoliosis and scoliotic attitude

Analysis of postural stability and body composition of women after unilateral mastectomy

Summary Introduction: The electrical bioimpedance method allows a non-invasive and precise assessment of the content of fat tissue, muscle mass or the amount of fluid in the body depending on the state of health or lifestyle. Changes in anthropometric features may affect postural stability, general physical fitness of women after mastectomy. In addition, changes in the distribution and amount of fat and lean body components may affect the ability to maintain balance. Aim of the study: Analysis of the relationship between postural stability and body composition of women after mastectomy based on posturographic examination. Material and methods: The study involved 40 women after mastectomy aged from 52 to 87 years. Postural Stability Test in static and dynamic mode on the Biodex Balance System platform was used to assess postural stability. The body bioimpedance method (BIA) was used to analyze the body composition. The research tool was the body composition analyzer Tanita MC 780 MA. The research was carried out in the Posturology Laboratory of the Institute of Physiotherapy at the Jan Kochanowski University in Kielce. Results and conclusions: Based on the research, a significant correlation was observed with a negative correlation in the Postural Stability Test, in static mode between fat mass and postural stability indexes. Also significant statistical results with a positive correlation were demonstrated in the same test between the total body water content and the postural stability indexes. Postural Stability Test in dynamic mode showed significant influence of lean and muscle mass in maintaining a stable posture. The standing posture of women after mastectomy was characterized by larger sublimations in the sagittal plane than the frontal plane (A / P> M // L)

Body posture in the sagittal plane and scoliotic variables in girls aged 7-18

ABSTRACTIntroduction. The aim of the study was to analyze the correlation between the variable posture in the sagittal plane and the scoliotic variables. Material and methods. The study involved 28 girls aged 7-18 years with scoliotic posture and scoliosis. Body posture as well as the spine were examined using Moiré’s spatial photogrammetry and the Exhibeon digital radiography method. Based on the size of the spinal curvature, the following were distinguished: scoliotic postures: 1-9° and scoliosis: ≥10°. Results. There were 21 (75%) with scoliotic posture and 7 (25%) with scoliosis. The size of the thoracic kyphosis and lumbar lordosis was normal. Conclusions. Between the body postural variables in the sagittal plane and the scoliotic variables, both positive (direct proportional) and negative (inversely proportional) correlations occurred. In the selection of scoliosis treatment method, the size of the postural variables in the sagittal plane should be taken into account, and each patient’s case should be individually considered

Body composition and SEMG amplitude of the spine rectifier in children with scoliotic lesions

The aim of the study was to analyze the relationship between body composition and the amplitude of SEMG rectifier spine in children with scoliotic changes. The spine was investigated using optoelectronic Diers formetric III 4D. Body composition was determined using a Tanita Body Composition Analyzer MC 780M. Analysis of the amplitude SEMG rectifier spine was performed using a 12-channel camera Noraxon TeleMyo DTS. The biggest differences in the absolute values of the studied variables related to body composition BMR (kJ). The most important and statistically significant predictors mock for the variable composition of the body spine and amplitude rectifier tested in different positions in the group of scoliosis proved standing position lumbar left (p = 0.01), standing position lumbar right (p = 0.01) and lying front right side of the thoracic (p = 0, 02). The variance explained by the independent variables in the model adopted is 35% of the total variation (R^2 = 0.35), indicating a small adjustment for the data, but the expected level of statistical significance (p = 0.01) has been fulfilled, and to give the corresponding the value of a statistical test F = 3.49. The group scoliotic bases most important and statistically significant predictor model was the torso up right thoracic (p = 0.0001), lower limbs up the right side of the lumbar (p = 0.044), trunk up the right side of the lumbar (p = 0.016) and the top of the torso thoracic left (p = 0.006). The model was explained only in 39% (R^2 = 0.39), which is low, but the target level of statistical significance (p = 0.001) was also satisfied. and give the corresponding value of the statistical test F = 4.89. In children with scoliotic changes SEMG amplitude measurement helps identify the muscles need strengthening or relaxation, as well as the selection of appropriate corrective exercises

“DEPHENCE” system—a novel regimen of therapy that is urgently needed in the high-grade serous ovarian cancer—a focus on anti-cancer stem cell and anti-tumor microenvironment targeted therapies

Ovarian cancer, especially high-grade serous type, is the most lethal gynecological malignancy. The lack of screening programs and the scarcity of symptomatology result in the late diagnosis in about 75% of affected women. Despite very demanding and aggressive surgical treatment, multiple-line chemotherapy regimens and both approved and clinically tested targeted therapies, the overall survival of patients is still unsatisfactory and disappointing. Research studies have recently brought some more understanding of the molecular diversity of the ovarian cancer, its unique intraperitoneal biology, the role of cancer stem cells, and the complexity of tumor microenvironment. There is a growing body of evidence that individualization of the treatment adjusted to the molecular and biochemical signature of the tumor as well as to the medical status of the patient should replace or supplement the foregoing therapy. In this review, we have proposed the principles of the novel regimen of the therapy that we called the “DEPHENCE” system, and we have extensively discussed the results of the studies focused on the ovarian cancer stem cells, other components of cancer metastatic niche, and, finally, clinical trials targeting these two environments. Through this, we have tried to present the evolving landscape of treatment options and put flesh on the experimental approach to attack the high-grade serous ovarian cancer multidirectionally, corresponding to the “DEPHENCE” system postulates