175 GHz, 400-fs-pulse harmonically mode-locked surface emitting semiconductor laser

We report a harmonically mode-locked vertical external cavity surface emitting laser (VECSEL) producing 400 fs pulses at a repetition frequency of 175 GHz with an average output power of 300 mW. Harmonic mode-locking was established using a 300 µm thick intracavity single crystal diamond heat spreader in thermal contact with the front surface of the gain sample using liquid capillary bonding. The repetition frequency was set by the diamond microcavity and stable harmonic mode locking was achieved when the laser cavity length was tuned so that the laser operated on the 117th harmonic of the fundamental cavity. When an etalon placed intracavity next to the gain sample, but not in thermal contact was used pulse groups were observed. These contained 300 fs pulses with a spacing of 5.9 ps. We conclude that to achieve stable harmonic mode locking at repetition frequencies in the 100s of GHz range in a VECSEL there is a threshold pulse energy above which harmonic mode locking is achieved and below which groups of pulses are observed

Total focussing method for volumetric imaging in immersion non destructive evaluation

This paper describes the use of a 550 (25x22) element 2MHz 2D piezoelectric composite array in immersion mode to image an aluminum test block containing a collection of artificial defects. The defects included a 1mm diameter side-drilled hole, a collection of 1mm slot defects with varying degrees of skew to the normal and a flat bottomed hole. The data collection was carried out using the full matrix capture; a scanning procedure was developed to allow the operation of the large element count array through a conventional 64-channel phased array controller. A 3D TFM algorithm capable of imaging in a dual media environment was implemented in MATLAB for the offline processing the raw scan data. This algorithm facilitates the creation of 3D images of defects while accounting for refraction effects at material boundaries. In each of the test samples interrogated the defects, and their spatial position, are readily identified using TFM. Defect directional information has been characterized using VTFM for defect exhibiting angles up to and including 45o of skew

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity

Science leadership for tomorrow: The role of schools of public affairs and universities in meeting needs of public science agencies

Recommendations and requirements for the preparation of personnel with some scientific or technological background to enter fields of public policy and administration are reported. University efforts to provide science administration graduate programs are outlined and increased cooperation between government and university resources is outlined

Saturated gain spectrum of VECSELs determined by transient measurement of lasing onset

We describe time-resolved measurements of the evolution of the spectrum of radiation emitted by an optically-pumped continuous-wave InGaAs-GaAs quantum well laser, recorded as lasing builds up from noise to steady state. We extract a fitting parameter corresponding to the gain dispersion of the parabolic spectrum equal to ?79 ± 30 fs2 and ?36 ± 6 fs2 for a resonant and anti-resonant structure, respectively. Furthermore the recorded evolution of the spectrum allows for the calculation of an effective FWHM gain bandwidth for each structure, of 11 nm and 18 nm, respectively

Particle Swarm Optimization and gravitational wave data analysis: Performance on a binary inspiral testbed

The detection and estimation of gravitational wave (GW) signals belonging to a parameterized family of waveforms requires, in general, the numerical maximization of a data-dependent function of the signal parameters. Due to noise in the data, the function to be maximized is often highly multi-modal with numerous local maxima. Searching for the global maximum then becomes computationally expensive, which in turn can limit the scientific scope of the search. Stochastic optimization is one possible approach to reducing computational costs in such applications. We report results from a first investigation of the Particle Swarm Optimization (PSO) method in this context. The method is applied to a testbed motivated by the problem of detection and estimation of a binary inspiral signal. Our results show that PSO works well in the presence of high multi-modality, making it a viable candidate method for further applications in GW data analysis.Comment: 13 pages, 5 figure

Full-gap superconductivity robust against disorder in heavy-fermion CeCu2Si2

A key aspect of unconventional pairing by the antiferromagnetic spin-fluctuation mechanism is that the superconducting energy gap must have opposite sign on different parts of the Fermi surface. Recent observations of non-nodal gap structure in the heavy-fermion superconductor CeCu$_2$Si$_2$ were then very surprising, given that this material has long been considered a prototypical example of a superconductor where the Cooper pairing is magnetically mediated. Here we present a study of the effect of controlled point defects, introduced by electron irradiation, on the temperature-dependent magnetic penetration depth $\lambda(T)$ in CeCu$_2$Si$_2$. We find that the fully-gapped state is robust against disorder, demonstrating that low-energy bound states, expected for sign-changing gap structures, are not induced by nonmagnetic impurities. This provides bulk evidence for $s_{++}$-wave superconductivity without sign reversal.Comment: 5 pages, 4 figures + Supplemental Material (1 page, 1 figure). Will appear in Phys. Rev. Let

Cutaneous B‐cell lymphomas: 2021 update on diagnosis, risk‐stratification, and management

Disease OverviewApproximately one‐fourth of primary cutaneous lymphomas are B‐cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B‐cell lymphoma, leg type (PCDLBCL, LT).DiagnosisDiagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin biopsy. Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B‐cell lymphomas from systemic B‐cell lymphomas with secondary skin involvement.Risk‐StratificationDisease histopathology remains the most important prognostic determinant in primary cutaneous B‐cell lymphomas. Both PCFCL and PCMZL are indolent lymphomas that infrequently disseminate to extracutaneous sites and are associated with 5‐year survival rates that exceed 95%. In contrast, PCDLBCL, LT is an aggressive lymphoma with an inferior prognosis.Risk‐Adapted TherapyBoth PCFCL and PCMZL patients with solitary or relatively few skin lesions may be effectively managed with local radiation therapy. While single‐agent rituximab may be employed for patients with more widespread skin involvement, multi‐agent chemotherapy is rarely appropriate. In contrast, management of patients with PCDLBCL, LT is comparable to the management of patients with systemic DLBCL.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162801/2/ajh25970.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162801/1/ajh25970_am.pd