Declining trends in student performance in lower secondary education

Student performance is related to motivation to learn. As motivation generally declines during lower secondary education, one might expect performance to decline as well during this period. Though, until now, it has been unclear whether this pattern exists. In the present study, we examined student performance during the early years of secondary education from a developmental perspective. Participants were 1544 Dutch secondary school students across three grades (grades 7 to 9). To investigate student performance trends, we analysed report card grades by using hierarchical linear modelling with two levels (level 1, time point; level 2, student). Potential moderators to be examined were (1) gender, (2) school type and (3) initial level. A linear decline in report card grades from grade 7 to 9 was found for boys and girls, in all school types, and regardless of initial level. Two variables moderated the steepness of the decline: school type and initial level. Gender and school type had a main effect on performance level. The same pattern was observed for the subset of 'core subjects'-Dutch, English and mathematics. Motivational and cognitive factors that may explain the performance decline are discussed

Promoting performance and motivation through a combination of intrinsic motivation stimulation and an extrinsic incentive

During the early stages of secondary education students’ motivation and performance levels decline. This study employed a case study approach to evaluate a learning environment called GUTS; Differentiated Challenging of Talent in School. GUTS was specifically designed to raise performance and motivation through a combination of (a) talent lessons as an intrinsic motivator and (b) a higher promotion standard as an extrinsic incentive. Participants were 156 students who started secondary education in grade 7 in school year 2013/2014, and participated in GUTS for three successive school years. Performance and motivation measures were longitudinally collected between grades 7 and 9 and were analysed in comparison to previous cohorts of students at the same school and students at other schools. Additionally, measures of well-being and self-esteem were included to explore possible collateral effects of the intervention. The GUTS cohort displayed generally higher levels of performance and motivation than the comparison groups. However, the GUTS cohort still showed the decline of performance and motivation between grades 7 and 9 that was also observed in the comparison groups. This study showed that performance and motivation levels were increased without collateral damage to the students’ overall sense of well-being and self-esteem, while GUTS was not a strong enough intervention to counter the motivation and performance decline over time. Possible reasons for the persistent decline of student performance and motivation are discussed in terms of various factors at the level of GUTS, the educational context and the needs of the developing adolescent

Relations of autonomous and controlled motivation with performance in secondary school students’ favoured and disfavoured subjects

Students in secondary education inevitably favour some subjects more than other subjects. This appraisal may affect how motivation relates to performance in these subjects. Whereas autonomous motivation is generally linked to positive school outcomes, the effect of controlled motivation is less clear. This study specifically focused on the associations of controlled motivation with performance in the context of favoured and disfavoured subjects. In the present study, secondary school students (N = 918) identified 2 favoured and 2 disfavoured subjects. Hierarchical linear modelling was performed to investigate the relationship of autonomous and controlled motivation with performance in these subjects. Results showed that autonomous motivation positively related to performance in both types of subjects. The association of controlled motivation with performance was negative in both contexts, and more negative in disfavoured subjects. For teaching practice, this means that teachers should always stimulate autonomous motivation, even for negatively appraised subjects

Promoting performance and motivation through a combination of intrinsic motivation stimulation and an extrinsic incentive

During the early stages of secondary education students’ motivation and performance levels decline. This study employed a case study approach to evaluate a learning environment called GUTS; Differentiated Challenging of Talent in School. GUTS was specifically designed to raise performance and motivation through a combination of (a) talent lessons as an intrinsic motivator and (b) a higher promotion standard as an extrinsic incentive. Participants were 156 students who started secondary education in grade 7 in school year 2013/2014, and participated in GUTS for three successive school years. Performance and motivation measures were longitudinally collected between grades 7 and 9 and were analysed in comparison to previous cohorts of students at the same school and students at other schools. Additionally, measures of well-being and self-esteem were included to explore possible collateral effects of the intervention. The GUTS cohort displayed generally higher levels of performance and motivation than the comparison groups. However, the GUTS cohort still showed the decline of performance and motivation between grades 7 and 9 that was also observed in the comparison groups. This study showed that performance and motivation levels were increased without collateral damage to the students’ overall sense of well-being and self-esteem, while GUTS was not a strong enough intervention to counter the motivation and performance decline over time. Possible reasons for the persistent decline of student performance and motivation are discussed in terms of various factors at the level of GUTS, the educational context and the needs of the developing adolescent

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium

Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer’s Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. We identified 13 loci with cross-ancestry associations including known loci at/near CR1 , BIN1 , TREM2 , CD2AP , PTK2B , CLU , SHARPIN , MS4A6A , PICALM , ABCA7 , APOE and two novel loci not previously reported at 11p12 ( LRRC4C ) and 12q24.13 ( LHX5-AS1 ). Reflecting the power of diverse ancestry in GWAS, we observed the SHARPIN locus using 7.1% the sample size of the original discovering single-ancestry GWAS (n=788,989). We additionally identified three GWS ancestry-specific loci at/near ( PTPRK ( P =2.4×10 -8 ) and GRB14 ( P =1.7×10 -8 ) in HIS), and KIAA0825 ( P =2.9×10 -8 in NHW). Pathway analysis implicated multiple amyloid regulation pathways (strongest with P adjusted =1.6×10 -4 ) and the classical complement pathway ( P adjusted =1.3×10 -3 ). Genes at/near our novel loci have known roles in neuronal development ( LRRC4C, LHX5-AS1 , and PTPRK ) and insulin receptor activity regulation ( GRB14 ). These findings provide compelling support for using traditionally-underrepresented populations for gene discovery, even with smaller sample sizes

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele