713 research outputs found
OOREA: An Object-Oriented Resources, Events, Agents Model for Enterprise Systems Design
A number of modeling approaches have been proposed in the literature for designing business information systems. This paper critiques prior data modeling approaches and presents an integrated object-oriented modeling approach that captures both the structural and the behavioral aspects of the business domain. Although there is considerable interest in object-oriented (OO) technologies in practice and in the information systems literature, there is no widely accepted OO modeling approach that facilitates the identification of objects from a business information processing perspective. Based on McCarthy’s (1982) resources, events, agents (REA) framework, the business process focused object-oriented ontology presented in this paper identifies the key resources, events, and agents in an enterprise information systems context. Termed OOREA, the ontology extends McCarthy’s REA model by capturing both the structural aspects of modeling, in terms of the objects of interest in the domain, and also the behavioral aspects in terms of the processes that modify objects. Application of the model is illustrated in the context of sales and related events for a retailing enterprise
Hierarchically-coupled hidden Markov models for learning kinetic rates from single-molecule data
We address the problem of analyzing sets of noisy time-varying signals that
all report on the same process but confound straightforward analyses due to
complex inter-signal heterogeneities and measurement artifacts. In particular
we consider single-molecule experiments which indirectly measure the distinct
steps in a biomolecular process via observations of noisy time-dependent
signals such as a fluorescence intensity or bead position. Straightforward
hidden Markov model (HMM) analyses attempt to characterize such processes in
terms of a set of conformational states, the transitions that can occur between
these states, and the associated rates at which those transitions occur; but
require ad-hoc post-processing steps to combine multiple signals. Here we
develop a hierarchically coupled HMM that allows experimentalists to deal with
inter-signal variability in a principled and automatic way. Our approach is a
generalized expectation maximization hyperparameter point estimation procedure
with variational Bayes at the level of individual time series that learns an
single interpretable representation of the overall data generating process.Comment: 9 pages, 5 figure
Low-Lying Neutron-Hole Transitions in the 207-Pb(p,p') Reaction at 135 MeV
This work was supported by National Science Foundation Grant PHY 75-00289 and Indiana Universit
Transitions to Proton States in the 90-Zr(p,p') Reaction at 160 MeV
This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit
Spin-Orbit Effects on the Shapes of Cross Sections in the 90-Zr(p,p') Reaction at 160 MeV
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
Wind-tunnel Investigation of the Effects of a Fence and a Leading-edge Notch on the Aerodynamic Loading Characteristics in Pitch of a 45 Degree Sweptback Wing at High Subsonic Speeds
Excitation of Neutron, Proton and Neutron-Hole States in the (p,p') Reaction at 160 MeV and 96 MeV
This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit
Core Polarization Amplitudes for Single-Neutron-Hole Transitions Excited in the 207-Pb(p,p') Reaction at 135 MeV and 61 MeV
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
Low-Lying Transitions in the 207-Pb(p,p') Reaction at 135 MeV and a Test of the DWIA
This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit
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