Giving Voice to the Voiceless: The Use of Digital Technologies by Marginalized Groups

This paper reports on a workshop hosted at the University of Massachusetts Amherst in September, 2018. The workshop, called “Giving Voice to the Voiceless: The Use of Digital Technologies by Marginalized Groups”, focused on discussing how marginalized groups use digital technologies to raise their voices. At the workshop, a diverse group of scholars and doctoral students presented research projects and perspectives on the role that digital technologies have in activist projects that represent marginalized groups that have gained momentum in the last few years. The studies and viewpoints presented shed light on four areas in which IS research can expand our understanding about how marginalized groups use digital technologies to address societal challenges: 1) the rise of cyberactivism, 2) resource mobilization for cyberactivism, 3) cyberactivism by and with marginalized groups, and 4) research methods for examining how marginalized groups use digital technologies

The genetics of cortical organisation and development: A study of 2,347 neuroimaging phenotypes

Our understanding of the genetic architecture of the human cerebral cortex is limited both in terms of the diversity of brain structural phenotypes and the anatomical granularity of their associations with genetic variants. Here, we conducted genome-wide association meta-analysis of 13 structural and diffusion magnetic resonance imaging derived cortical phenotypes, measured globally and at 180 bilaterally averaged regions in 36,843 individuals from the UK Biobank and the ABCD cohorts. These phenotypes include cortical thickness, surface area, grey matter volume, and measures of folding, neurite density, and water diffusion. We identified 4,349 experiment-wide significant loci associated with global and regional phenotypes. Multiple lines of analyses identified four genetic latent structures and causal relationships between surface area and some measures of cortical folding. These latent structures partly relate to different underlying gene expression trajectories during development and are enriched for different cell types. We also identified differential enrichment for neurodevelopmental and constrained genes and demonstrate that common genetic variants associated with surface area and volume specifically are associated with cephalic disorders. Finally, we identified complex inter-phenotype and inter-regional genetic relationships among the 13 phenotypes which reflect developmental differences among them. These analyses help refine the role of common genetic variants in human cortical development and organisation

PhysioSkin: Rapid Fabrication of Skin-Conformal Physiological Interfaces

Advances in rapid prototyping platforms have made physiological sensing accessible to a wide audience. However, off-the-shelf electrodes commonly used for capturing biosignals are typically thick, non-conformal and do not support customization. We present PhysioSkin, a rapid, do-it-yourself prototyping method for fabricating custom multi-modal physiological sensors, using commercial materials and a commodity desktop inkjet printer. It realizes ultrathin skin-conformal patches (~1μm) and interactive textiles that capture sEMG, EDA and ECG signals. It further supports fabricating devices with custom levels of thickness and stretchability. We present detailed fabrication explorations on multiple substrate materials, functional inks and skin adhesive materials. Informed from the literature, we also provide design recommendations for each of the modalities. Evaluation results show that the sensor patches achieve a high signal-to-noise ratio. Example applications demonstrate the functionality and versatility of our approach for prototyping a next generation of physiological devices that intimately couple with the human body

Equal opportunities: Do shareable interfaces promote more group participation than single users displays?

Computers designed for single use are often appropriated suboptimally when used by small colocated groups working together. Our research investigates whether shareable interfaces–that are designed for more than one user to inter-act with–can facilitate more equitable participation in colocated group settings compared with single user displays. We present a conceptual framework that characterizes Shared Information Spaces (SISs) in terms of how they constrain and invite participation using different entry points. An experiment was conducted that compared three different SISs: a physical-digital set-up (least constrained), a multitouch tabletop (medium), and a laptop display (most constrained). Statistical analyses showed there to be little difference in participation levels between the three conditions other than a predictable lack of equity of control over the interface in the laptop condition. However, detailed qualitative analyses revealed more equitable participation took place in the physical-digital condition in terms of verbal utterances over time. Those who spoke the least contributed most to the physical design task. The findings are discussed in relation to the conceptual framework and, more generally, in terms of how to select, design, and combine different display technologies to support collaborative activities

Compartiendo 15 años del Programa "La universidad escucha las escuelas": perspectivas, debates y propuestas desde el Trabajo Social Institucional (2001-2016)

Colección: PUEE Programa La Universidad escucha las escuelasFil: Rotondi, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Verón, Dolores. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Gregorio, Lilian. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Gaitán, Paula. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Corona, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Fonseca, Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Giordano, Rosa. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Miani, Ana. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Varela, Adriana. Municipalidad de Oliva, Córdoba. Área de Salud; ArgentinaFil: Saal, Gabriel. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.Fil: Milesi, Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Oviedo, Elena. Ministerio de Educación de Córdoba; Argentina.Fil: Santillán, Susana. Ministerio de Educación de Córdoba; Argentina.Fil: Liascovitz, Olga Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Molina, Andrea Gisela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Benedetti, Cynthia E. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Colomba, Rocío. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Rossi Rotondi, Enzo. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Mignola, Marcos. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Barraza, Elizabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Rossi Rotondi, Bruno. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Tramontana, Maxime. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Artazo, Cristina Gabriela. Universidad Nacional de Villa María. Instituto Académico Pedagógico de Ciencias Sociales; Argentina.Fil: Artazo, Cristina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Centro de Estudios Avanzados; Argentina.Fil: Artazo, Cristina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Bard Wigdor, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Centro de Estudios Avanzados; Argentina.Fil: Bard Wigdor, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina.La presente publicación recupera y pone a discusión algunas de las producciones derivadas de la triple dimensión que mantuvo activo al equipo: la docencia, la investigación y la extensión realizadas en el marco de la Cátedra Teoría, Espacios y Estrategias de intervención IV - Instituciona, de la Licenciatura en Trabajo Social, Facultad de Ciencias Sociales, Universidad Nacional de Córdoba, entre 2001 y 2016. En esta ocasión nos hemos detenido, particularmente, en aquellas producciones vinculadas al Programa “La Universidad escucha las escuelas (PUEE) 2001-2016” con motivo del cumplimiento de sus primeros quince años. Lo hacemos porque el Programa ha sido marco y ámbito de trabajo del equipo de docentes de la cátedra, que desarrolló en este período su tarea, incorporando, además, adscriptos, becarios, ayudantes, estudiantes, colegas y profesionales de nuestra Universidad de las más diversas disciplinas. Trabajo Social, Psicología, Ciencias Agropecuarias, Biología, Arquitectura, Ciencias de la educación, entre otras, sumaron, en ámbitos de reflexión, diversos debates, realizando de manera conjunta extensión e investigación, lo cual ha enriquecido y aportado en múltiples direcciones, haciendo visible los principales rasgos del programa: la sinergia, la innovación y la interdisciplina. El programa se instala a partir de un contexto complejo. El año 2001 nos demandó e interpeló como equipo y nos desafió a gestar procesos de intervención social directa en escuelas que atravesaban situaciones difíciles, tanto desde lo social como desde lo político. Y que, por otra parte, demandaron a la cátedra ante situaciones de violencia; o dificultades para incorporar las políticas sociales en la trama institucional; o para efectuar el seguimiento y evaluación de proyectos, como lo fue en las escuelas en las que se intentaba incorporar la educación sexual, entre otras cuestiones.Fil: Rotondi, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Verón, Dolores. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Gregorio, Lilian. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Gaitán, Paula. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Corona, Marcelo. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Fonseca, Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Giordano, Rosa. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Miani, Ana. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Varela, Adriana. Municipalidad de Oliva, Córdoba. Área de Salud; ArgentinaFil: Saal, Gabriel. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina.Fil: Milesi, Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Oviedo, Elena. Ministerio de Educación de Córdoba; Argentina.Fil: Santillán, Susana. Ministerio de Educación de Córdoba; Argentina.Fil: Liascovitz, Olga Andrea. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Molina, Andrea Gisela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Benedetti, Cynthia E. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Colomba, Rocío. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Rossi Rotondi, Enzo. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Mignola, Marcos. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Barraza, Elizabeth. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Rossi Rotondi, Bruno. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Tramontana, Maxime. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Artazo, Cristina Gabriela. Universidad Nacional de Villa María. Instituto Académico Pedagógico de Ciencias Sociales; Argentina.Fil: Artazo, Cristina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Centro de Estudios Avanzados; Argentina.Fil: Artazo, Cristina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Bard Wigdor, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Centro de Estudios Avanzados; Argentina.Fil: Bard Wigdor, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina.Ciencias Sociales Interdisciplinaria

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation. Analysis of blood cell traits in the UK Biobank and other cohorts illuminates the full genetic architecture of hematopoietic phenotypes, with evidence supporting the omnigenic model for complex traits and linking polygenic burden with monogenic blood diseases