Analysis of total urinary catecholamines by liquid chromatography: methodology, routine experience and clinical interpretations of results

A simple routine method is described for simultaneous assay of total urinary adrenaline, noradrenaline and dopamine. The catecholamines are pre-purified on a small ion-exchange column, separated by reversed phase ion-pair liquid chromatography, and are quantitated by electrochemical detection. The method was routinely applied to 422 urines. Elevated values were found in four urine specimens obtained from patients with histologically proven phaeochromocytomas. Virtually no interference by endogenous or exogenous compounds was found. Values for urinary catecholamines determined by fluorimetric analysis agreed with those obtained by high pressure liquid chromatography with electrochemical detection. Within-day CVs for the compounds ranged from 5.2-11.9%, between-day CVs from 3.3-6.6%. The normal range (95% confidence level) was 20-230 micrograms/24 h for noradrenaline and 1-35 micrograms/24 h for adrenaline

Letter from E. C. Wieland to Senator Langer Regarding the North Dakota Farmers Union, April 19, 1955

This letter dated April 19, 1955 from E. C. Wieland to United States Senator William Langer encloses a resolution from the North Dakota Farmers Union (NDFU) resolution concerning the Garrison Dam. The NDFU states they would like more research surrounding the energy produced from the pool level height at the Garrison Dam. They admit that the energy produced would be beneficial to local farmers but more concrete details must be surveyed first. The letter has a small hand-written note on it. The resolution is enclosed with this document. See also: Letter from Senator Langer to E. C. Wieland Regarding His Resolution, April 26, 1955https://commons.und.edu/langer-papers/1464/thumbnail.jp

Integrating Corporate Sustainability and Organizational Strategy Within the Undergraduate Business Curriculum

Corporate sustainability (CS) requires organizations to shift focus from short-term financial goals to further consider the long-term social, environmental, and economic implications of their operations. Despite a lack of regulations in the United States requiring companies to disclose social and environmental measures, more than 80% of U.S. corporations voluntarily release corporate responsibility reports. The increased focus of CS in practice has impacted many business curricula to adapt CS-related courses (such as business ethics); however, we present results that indicate that such means may have limited influence on students’ views concerning the legitimacy of social and environmental issues in regard to corporate decision making. More consideration is needed to determine how CS-related topics can be effectively integrated within business curriculums. We propose incorporating CS within the Organizational Strategy capstone course and assess its effectiveness via survey analysis. Suggestions for course design are provided

A meta aggregation of qualitative research on retention of general practitioners in remote Canada and Australia

OBJECTIVE: Our aim was to systematically review qualitative evidence regarding the experiences and perceptions of general practitioners and what factors influence their retention in remote areas of Canada and Australia. The objectives were to identify gaps and inform policy to improve retention of remote general practitioners, which should in turn improve the health of our marginalised remote communities. DESIGN: Meta-aggregation of qualitative studies. SETTING: Remote general practice in Canada and Australia. PARTICIPANTS: General practitioners and general practice registrars who had worked in a remote area for a minimum of one year and/or were intending to stay remote long term in their current placement. RESULTS: Twenty-four studies were included in the final analysis. A total of 811 participants made up the sample with a length of retention ranging from 2 to 40 years. Six synthesised findings were identified from a total of 401 findings; these were around peer and professional support, organisational support, uniqueness of remote lifestyle and work, burnout and time off, personal family issues and cultural and gender issues. CONCLUSIONS: Long term retention of doctors in remote areas of Australia and Canada is influenced by a range of negative and positive perceptions, and experiences with key factors being professional, organisational, or personal. All six factors span a spectrum of policy domains and service responsibilities and therefore a central coordinating body could be well placed to implement a multifactorial retention strategy

Performance of Airborne Precision Spacing Under Realistic Wind Conditions and Limited Surveillance Range

With the expected worldwide increase of air traffic during the coming decade, both the Federal Aviation Administration's (FAA's) Next Generation Air Transportation System (NextGen), as well as Eurocontrol's Single European Sky ATM Research (SESAR) program have, as part of their plans, air traffic management (ATM) solutions that can increase performance without requiring time-consuming and expensive infrastructure changes. One such solution involves the ability of both controllers and flight crews to deliver aircraft to the runway with greater accuracy than they can today. Previous research has shown that time-based spacing techniques, wherein the controller assigns a time spacing to each pair of arriving aircraft, can achieve this goal by providing greater runway delivery accuracy and producing a concomitant increase in system-wide performance. The research described herein focuses on one specific application of time-based spacing, called Airborne Precision Spacing (APS), which has evolved over the past ten years. This research furthers APS understanding by studying its performance with realistic wind conditions obtained from atmospheric sounding data and with realistic wind forecasts obtained from the Rapid Update Cycle (RUC) short-range weather forecast. In addition, this study investigates APS performance with limited surveillance range, as provided by the Automatic Dependent Surveillance-Broadcast (ADS-B) system, and with an algorithm designed to improve APS performance when ADS-B surveillance data is unavailable. The results presented herein quantify the runway threshold delivery accuracy of APS under these conditions, and also quantify resulting workload metrics such as the number of speed changes required to maintain spacing

PROGRESS IN THE STUDY OF THE γ-DECAY OF THE GIANT DIPOLE RESONANCE IN HOT NUCLEI

The problem of the damping of the Giant Dipole Resonance (GDR) at finite temperature at T>2 MeV is discussed here. The experimental results are based on fusion evaporation reactions. The most recent results on the mass region A = 132 ( Ce isotopes) obtained in exclusive measurements are compared with the existing results on the A = 110–120 region ( Sn isotopes). The comparison with the theoretical predictions based on thermal shape fluctuations is also discussed. The GDR width is found to increase also in the region T>2 MeV and this is accounted by the combined effect of the increase of the compound nucleus width (smaller lifetime) and to the increase of the average deformation of the nucleus

Measurement of the reaction \gamma p \TO K^ + \Lambda(1520) at photon energies up to 2.65 GeV

The reaction \gamma p \TO K^+\Lambda(1520) was measured in the energy range from threshold to 2.65 GeV with the SAPHIR detector at the electron stretcher facility ELSA in Bonn. The $\Lambda(1520)$ production cross section was analyzed in the decay modes $pK^-$, $n \bar{K}^0$, $\Sigma^{\pm}\pi^{\mp}$, and $\Lambda\pi^+\pi^-$ as a function of the photon energy and the squared four-momentum transfer $t$. While the cross sections for the inclusive reactions rise steadily with energy, the cross section of the process \gamma p \TO K^+\Lambda(1520) peaks at a photon energy of about 2.0 GeV, falls off exponentially with $t$, and shows a slope flattening with increasing photon energy. The angular distributions in the $t$-channel helicity system indicate neither a $K$ nor a $K^\star$ exchange dominance. The interpretation of the $\Lambda(1520)$ as a $\Sigma(1385)\pi$ molecule is not supported.Comment: 11 pages, 16 figures, 4 table

Synthesis of [2‐{(4‐chlorophenyl) (4‐[ 125 I]iodophenyl)} methoxyethyl]‐1‐piperidine‐3‐carboxylic acid, [ 125 I]CIPCA: A potential radiotracer for GABA uptake sites

The synthesis of racemic [2‐{(4‐Chlorophenyl) (4‐iodophenyl)} methoxyethyl]‐1‐piperidine‐3‐carboxylic acid, (CIPCA) and its radioiodinated analog [ 125ß I]CIPCA is described. CIPCA was synthesized from 4‐iodobenzoyl chloride in five steps in 16% overall yield. Ammonium sulfate catalyzed solid‐state isotopic exchange of CIPCA with Na 125 I provided [ 125 I]CIPCA in 34% isolated radiochemical yield at a specific activity of 118 Ci/mmol. [ 125 ICIPCA] demonstrated moderate brain extraction and good in vivo radiostability in preliminary biodistribution studies conducted in CD‐1 mice. [ 125 I]CIPCA is a potentially useful radiotracer for study of the GABA uptake system.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90161/1/2580361008_ftp.pd