Magnetic domain structure and dynamics in interacting ferromagnetic stacks with perpendicular anisotropy

The time and field dependence of the magnetic domain structure at magnetization reversal were investigated by Kerr microscopy in interacting ferromagnetic Co/Pt multilayers with perpendicular anisotropy. Large local inhomogeneous magnetostatic fields favor mirroring domain structures and domain decoration by rings of opposite magnetization. The long range nature of these magnetostatic interactions gives rise to ultra-slow dynamics even in zero applied field, i.e. it affects the long time domain stability. Due to this additionnal interaction field, the magnetization reversal under short magnetic field pulses differs markedly from the well-known slow dynamic behavior. Namely, in high field, the magnetization of the coupled harder layer has been observed to reverse more rapidly by domain wall motion than the softer layer alone.Comment: 42 pages including 17 figures. submitted to JA

Simulation of neutrino and charged particle production and propagation in the atmosphere

A precise evaluation of the secondary particle production and propagation in the atmosphere is very important for the atmospheric neutrino oscillation studies. The issue is addressed with the extension of a previously developed full 3-Dimensional Monte-Carlo simulation of particle generation and transport in the atmosphere, to compute the flux of secondary protons, muons and neutrinos. Recent balloon borne experiments have performed a set of accurate flux measurements for different particle species at different altitudes in the atmosphere, which can be used to test the calculations for the atmospheric neutrino production, and constrain the underlying hadronic models. The simulation results are reported and compared with the latest flux measurements. It is shown that the level of precision reached by these experiments could be used to constrain the nuclear models used in the simulation. The implication of these results for the atmospheric neutrino flux calculation are discussed.Comment: 11 pages, 9 figure

The metabolic cost of lowering blood pressure with hydrochlorothiazide

Abstract Background The landmark Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) placed a new spotlight on thiazide diuretics as the first-line therapy for hypertension. This is concerning as thiazide-diuretics may contribute to comorbidities associated with the current epidemic of obesity. Previous randomized clinical trials have linked thiazide diuretic treatment to insulin resistance, metabolic syndrome, and increased incidence of type 2 diabetes. Methods This proof of concept, longitudinal, randomized, double–blind study evaluated the effects of the angiotensin II receptor blocker Valsartan and the specific thiazide diuretic Hydrochlorothiazide (HCTZ) on hepatic triglyceride level (primary outcome), as well as triglyceride levels within other organs including the heart, skeletal muscle, and pancreas. Additionally, we evaluated whether myocardial function, insulin sensitivity, and insulin secretion were affected by these treatments. Results Hepatic TG levels increased by 57% post HCTZ treatment: ∆hTG HCTZ = 4.12% and remained unchanged post Valsartan treatment: ∆hTG V = 0.06%. The elevation of hepatic TG levels after HCTZ treatment was additionally accompanied by a reduction in insulin sensitivity: ∆SI HCTZ = -1.14. Treatment with Valsartan resulted in improved insulin sensitivity: ∆SI V = 1.24. Treatment-induced changes in hepatic TG levels and insulin sensitivity were statistically significant between groups (phTG = 0.0098 and pSI = 0.0345 respectively). Disposition index, DI, remained unchanged after HCTZ treatment: ∆DI HCTZ = -141 but it was increased by a factor of 2 after treatment with Valsartan: ∆DI V =1018). However, the change between groups was not statistically significant. Both therapies did not modify abdominal visceral and subcutaneous fat mass as well as myocardial structure and function. Additionally, myocardial, pancreatic, and skeletal muscle triglyceride deposits remained unchanged in both therapeutic arms. Conclusions Our findings are two-fold and relate to hepatic steatosis and insulin sensitivity. HCTZ treatment worsened hepatic steatosis measured as hepatic triglyceride content and reduced insulin sensitivity. Valsartan treatment did not affect hepatic triglyceride levels and improved insulin sensitivity. The results of this study reinforce the message that in patients at risk for type 2 diabetes it is particularly important to choose an antihypertensive regimen that lowers blood pressure without exacerbating patient’s metabolic profile

Cosmic-Ray Proton and Helium Spectra from the First CREAM Flight

Cosmic-ray proton and helium spectra have been measured with the balloon-borne Cosmic Ray Energetics And Mass experiment flown for 42 days in Antarctica in the 2004-2005 austral summer season. High-energy cosmic-ray data were collected at an average altitude of ~38.5 km with an average atmospheric overburden of ~3.9 g cm$^{-2}$. Individual elements are clearly separated with a charge resolution of ~0.15 e (in charge units) and ~0.2 e for protons and helium nuclei, respectively. The measured spectra at the top of the atmosphere are represented by power laws with a spectral index of -2.66 $\pm$ 0.02 for protons from 2.5 TeV to 250 TeV and -2.58 $\pm$ 0.02 for helium nuclei from 630 GeV/nucleon to 63 TeV/nucleon. They are harder than previous measurements at a few tens of GeV/nucleon. The helium flux is higher than that expected from the extrapolation of the power law fitted to the lower-energy data. The relative abundance of protons to helium nuclei is 9.1 $\pm$ 0.5 for the range from 2.5 TeV/nucleon to 63 TeV/nucleon. This ratio is considerably smaller than the previous measurements at a few tens of GeV/nucleon.Comment: 20 pages, 4 figure

Measurement of the gluon PDF at small x with neutrino telescopes

We analyze the possibility that neutrino telescopes may provide an experimental determination of the slope lambda of the gluon distribution in the proton at momentum fractions x smaller than the accelerator reach. The method is based on a linear relation between lambda and the spectral index (slope) of the down-going atmospheric muon flux above 100 TeV, for which there is no background. Considering the uncertainties in the charm production cross section and in the cosmic ray composition, we estimate the error on the measurement of lambda through this method, excluding the experimental error of the telescopes, to be ~ +/- 0.2Comment: 16 pages with 16 figures - new version, comments added, same results and figure