Overly honest data repository development

After a year of development, the library at the University of Illinois at Urbana-Champaign has launched a repository, called the Illinois Data Bank (https://databank.illinois.edu/), to provide Illinois researchers with a free, self-serve publishing platform that centralizes, preserves, and provides persistent and reliable access to Illinois research data. This article presents a holistic view of development by discussing our overarching technical, policy, and interface strategies. By openly presenting our design decisions, the rationales behind those decisions, and associated challenges this paper aims to contribute to the library community’s work to develop repository services that meet growing data preservation and sharing needs.Ope

Comparison of nonculture blood-based tests for diagnosing invasive Aspergillosis in an animal model

Contains fulltext : 172175.pdf (publisher's version ) (Closed access

Treatise On The Accentuation : Prose Books of The Old Testament

Oxfordxiv, 155 p. + 36 p.; 23 c

East Greenwich Town Hall

East Greenwich Town Hall, originally Kent County Courthouse, is shown in this 1980 photograph. It was constructed in 1804 by Oliver Wickes who drew inspiration from the existing Newport and Providence Colony Houses. Wickes\u27 design, however, favors the federalist forms of the early 19th century over the colonial style of the older structures. Originally the five state houses were used in rotation by the governor and legislature of Rhode Island, but by the 1850s this location was no longer used. For a time it served as Kent County Courthouse, but as it was used infrequently it was turned over to the town of East Greenwich as Town Hall. This photograph shows the building before an edition was constructed in the mid 1990s, although the addition would not have be visible from this angle.https://digitalcommons.ric.edu/ri_architecture/1002/thumbnail.jp

Molecular Mechanisms of Fluconazole Resistance in Candida dubliniensis Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis

Candida dubliniensis is a newly identified species of Candida that is phenotypically similar to but genetically distinct from C. albicans. This organism has been recovered with increasing frequency from the oral cavities of human immunodeficiency virus (HIV)-infected and AIDS patients and has been implicated as a causative agent of oral candidiasis and systemic disease. In the present study we characterized the molecular mechanisms of resistance to fluconazole (FLC) in C. dubliniensis clinical isolates from two different HIV-infected patients with oropharyngeal candidiasis. Isolates were identified to the species level by phenotypic and genotypic tests. DNA-typing techniques were used to assess strain identity. Antifungal susceptibility testing was performed by NCCLS techniques. Northern blotting analysis was used to monitor the expression of genes encoding lanosterol demethylase (ERG11) and efflux transporters (CDR and MDR1) in matched sets of C. dubliniensis-susceptible and -resistant isolates by using probes generated from their homologous C. albicans sequences. In addition, ERG11 genes were amplified by PCR, and their nucleotide sequences were determined in order to detect point mutations with a possible effect in the affinity for azoles. Decreasing susceptibilities to FLC were detected in C. dubliniensis isolates recovered from both patients during the course of treatment. FLC-resistant C. dubliniensis isolates from one patient demonstrated combined upregulation of the MDR1, CDR1, and ERG11 genes. Among the isolates from the second patient, all isolates showing decreased susceptibility to FLC demonstrated upregulation of MDR1, whereas the levels of mRNA for the ERG11 genes remained constant and the expression of CDR genes was negligible. Fourteen point mutations were found in the ERG11 genes of the isolates with decreased susceptibility to FLC. These data demonstrate that the development of azole resistance in C. dublinensis clinical isolates from HIV-infected patients treated with FLC is mediated by multiple molecular mechanisms of resistance, similar to the observations found in the case of C. albicans