Tidal Disruption of Protoclusters in Giant Molecular Clouds

We study the collapse of protoclusters within a giant molecular cloud (GMC) to determine the conditions under which collapse is significantly disrupted. Motivated by observations of star forming regions which exhibit flattened cloud structures, this study considers collapsing protoclusters with disk geometries. The collapse of a 10^3 Msun protocluster initially a distance of 2-10 pc from a 10^3 - 10^6 Msun point mass is numerically calculated. Simulations with zero initial relative velocity between the two are completed as well as simulations with relative velocities consistent with those observed in GMCs. The results allow us to define the conditions under which it is safe to assume protocluster collapse proceeds as if in isolation. For instance, we find the collapse of a 10^3 Msun protocluster will be significantly disrupted if it is within 2-4 pc of a 10^4 Msun point mass. Thus, the collapse of a 10^3 Msun protocluster can be considered to proceed as if in isolation if it is more than ~ 4 pc away from a 10^4 Msun compact object. In addition, in no portion of the sampled parameter space does the gravitational interaction between the protocluster disk and the massive particle significantly disperse the disk into the background GMC. We discuss the distribution of clusters of young stellar objects within the Perseus and Mon R2 star forming regions, which are consistent with the results of our simulations and the limitations of our results in gas dominated regions such as the Orion cloud.Comment: 12 pages, 6 figures, Accepted for publication in Ap

Freshwater fishes of Connecticut

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Using the Heterodyne Method to Measure Velocities on Shock Physics Experiments

We developed a velocimeter system several years ago that uses the heterodyne method [1]. This system is assembled from commercially available components that were developed for the telecommunications industry. There are several advantages of this system over the traditional VISAR method that has made it increasingly popular. This system is compact, portable, and relatively inexpensive. The maximum velocity of this system is determined by the electrical bandwidth of the electronics and the digitizer sample rate. The maximum velocity for the system described here is over 5 km/s

PDV Probe Alignment Technique

This alignment technique was developed while performing heterodyne velocimetry measurements at LLNL. There are a few minor items needed, such as a white card with aperture in center, visible alignment laser, IR back reflection meter, and a microscope to view the bridge surface. The work was performed on KCP flyers that were 6 and 8 mils wide. The probes used were Oz Optics manufactured with focal distances of 42mm and 26mm. Both probes provide a spot size of approximately 80?m at 1550nm. The 42mm probes were specified to provide an internal back reflection of -35 to -40dB, and the probe back reflections were measured to be -37dB and -33dB. The 26mm probes were specified as -30dB and both measured -30.5dB. The probe is initially aligned normal to the flyer/bridge surface. This provides a very high return signal, up to -2dB, due to the bridge reflectivity. A white card with a hole in the center as an aperture can be used to check the reflected beam position relative to the probe and launch beam, and the alignment laser spot centered on the bridge, see Figure 1 and Figure 2. The IR back reflection meter is used to measure the dB return from the probe and surface, and a white card or similar object is inserted between the probe and surface to block surface reflection. It may take several iterations between the visible alignment laser and the IR back reflection meter to complete this alignment procedure. Once aligned normal to the surface, the probe should be tilted to position the visible alignment beam as shown in Figure 3, and the flyer should be translated in the X and Y axis to reposition the alignment beam onto the flyer as shown in Figure 4. This tilting of the probe minimizes the amount of light from the bridge reflection into the fiber within the probe while maintaining the alignment as near normal to the flyer surface as possible. When the back reflection is measured after the tilt adjustment, the level should be about -3dB to -6dB higher than the probes specified back reflection. This 3 to 6dB increase in back reflection from the surface relative to the probes specified back reflection is the optimal level for acquiring data from the flyer. Data obtained with the LLNL system is shown in Figure 5

Down Conversion Scheme for PDV

Author Institution: Lawrence Livermore National LaboratorySlides presented at the 2nd Annual Photonic Doppler Velocimetry (PDV) Workshop held at Lawrence Livermore National Laboratory, Livermore, California, August 16-17, 2007

Early antenatal prediction of gestational diabetes in obese women: development of prediction tools for targeted intervention

All obese women are categorised as being of equally high risk of gestational diabetes (GDM) whereas the majority do not develop the disorder. Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. Our aim was to develop a prediction tool for early identification of obese women at high risk of GDM to facilitate targeted interventions in those most likely to benefit. Clinical and anthropometric data and non-fasting blood samples were obtained at 15+0–18+6 weeks’ gestation in 1303 obese pregnant women from UPBEAT, a randomised controlled trial of a behavioural intervention. Twenty one candidate biomarkers associated with insulin resistance, and a targeted nuclear magnetic resonance (NMR) metabolome were measured. Prediction models were constructed using stepwise logistic regression. Twenty six percent of women (n = 337) developed GDM (International Association of Diabetes and Pregnancy Study Groups criteria). A model based on clinical and anthropometric variables (age, previous GDM, family history of type 2 diabetes, systolic blood pressure, sum of skinfold thicknesses, waist:height and neck:thigh ratios) provided an area under the curve of 0.71 (95%CI 0.68–0.74). This increased to 0.77 (95%CI 0.73–0.80) with addition of candidate biomarkers (random glucose, haemoglobin A1c (HbA1c), fructosamine, adiponectin, sex hormone binding globulin, triglycerides), but was not improved by addition of NMR metabolites (0.77; 95%CI 0.74–0.81). Clinically translatable models for GDM prediction including readily measurable variables e.g. mid-arm circumference, age, systolic blood pressure, HbA1c and adiponectin are described. Using a ≥35% risk threshold, all models identified a group of high risk obese women of whom approximately 50% (positive predictive value) later developed GDM, with a negative predictive value of 80%. Tools for early pregnancy identification of obese women at risk of GDM are described which could enable targeted interventions for GDM prevention in women who will benefit the most

Collapse of Rotating Magnetized Molecular Cloud Cores and Mass Outflows

Collapse of the rotating magnetized molecular cloud core is studied with the axisymmetric magnetohydrodynamical (MHD) simulations. Due to the change of the equation of state of the interstellar gas, the molecular cloud cores experience several different phases as collapse proce eds. In the isothermal run-away collapse ($n \lesssim 10^{10}{\rm H_2 cm}^{-3}$), a pseudo-disk is formed and it continues to contract till the opaque core is fo rmed at the center. In this disk, a number of MHD fast and slow shock pairs appear running parallelly to the disk. After the equation of state becomes hard, an adiabatic core is formed, which is separated from the isothermal contracting pseudo-disk by the accretion shock front facing radially outwards. By the effect of the magnetic tension, the angular momentum is transferred from the disk mid-plane to the surface. The gas with excess angular momentum near the surface is finally ejected, which explains the molecular bipolar outflow. Two types of outflows are observed. When the poloidal magnetic field is strong (magnetic energy is comparable to the thermal one), a U-shaped outflow is formed in which fast moving gas is confined to the wall whose shape looks like a capit al letter U. The other is the turbulent outflow in which magnetic field lines and velocity fi elds are randomly oriented. In this case, turbulent gas moves out almost perpendicularly from the disk. The continuous mass accretion leads to the quasistatic contraction of the first core. A second collapse due to dissociation of H$_2$ in the first core follows. Finally another quasistatic core is again formed by atomic hydrogen (the second core). It is found that another outflow is ejected around the second atomic core, which seems to correspond to the optical jets or the fast neutral winds.Comment: submitted to Ap

The Diverse Stellar Populations of the W3 Star Forming Complex

An 800 sq-arcmin mosaic image of the W3 star forming complex obtained with the Chandra X-ray Observatory gives a valuable new view of the spatial structure of its young stellar populations. The Chandra image reveals about 1300 faint X-ray sources, most of which are PMS stars in the cloud. Some, but not all, of the high-mass stars producing hypercompact and ultracompact H II (UCHII) regions are also seen, as reported in a previous study. The Chandra images reveal three dramatically different embedded stellar populations. The W3 Main cluster extends over 7 pc with about 900 X-ray stars in a nearly-spherical distribution centered on the well-studied UCHII regions and high-mass protostars. The cluster surrounding the prototypical UCHII region W3(OH) shows a much smaller (<0.6 pc), asymmetrical, and clumpy distribution of about 50 PMS stars. The massive star ionizing the W3 North H II region is completely isolated without any accompanying PMS stars. In W3 Main, the inferred ages of the widely distributed PMS stars are significantly older than the inferred ages of the central OB stars illuminating the UCHIIs. We suggest that different formation mechanisms are necessary to explain the diversity of the W3 stellar populations: cluster-wide gravitational collapse with delayed OB star formation in W3 Main, collect-and-collapse triggering by shock fronts in W3(OH), and a runaway O star or isolated massive star formation in W3 North.Comment: To appear in the Astrophysical Journal. 21 pages, 5 figures. A version with high-quality figures is available at http://www.astro.psu.edu/users/edf/W3_Chandra.pd

The genetic organisation of prokaryotic two-component system signalling pathways

<p>Abstract</p> <p>Background</p> <p>Two-component systems (TCSs) are modular and diverse signalling pathways, involving a stimulus-responsive transfer of phosphoryl groups from transmitter to partner receiver domains. TCS gene and domain organisation are both potentially informative regarding biological function, interaction partnerships and molecular mechanisms. However, there is currently little understanding of the relationships between domain architecture, gene organisation and TCS pathway structure.</p> <p>Results</p> <p>Here we classify the gene and domain organisation of TCS gene loci from 1405 prokaryotic replicons (>40,000 TCS proteins). We find that 200 bp is the most appropriate distance cut-off for defining whether two TCS genes are functionally linked. More than 90% of all TCS gene loci encode just one or two transmitter and/or receiver domains, however numerous other geometries exist, often with large numbers of encoded TCS domains. Such information provides insights into the distribution of TCS domains between genes, and within genes. As expected, the organisation of TCS genes and domains is affected by phylogeny, and plasmid-encoded TCS exhibit differences in organisation from their chromosomally-encoded counterparts.</p> <p>Conclusions</p> <p>We provide here an overview of the genomic and genetic organisation of TCS domains, as a resource for further research. We also propose novel metrics that build upon TCS gene/domain organisation data and allow comparisons between genomic complements of TCSs. In particular, '<it>percentage orphaned TCS genes</it>' (or 'Dissemination') and '<it>percentage of complex loci</it>' (or 'Sophistication') appear to be useful discriminators, and to reflect mechanistic aspects of TCS organisation not captured by existing metrics.</p

Factors to Consider when Choosing a Probe

Author Institution: Lawrence Livermore National LaboratorySlides presented at the 3nd Annual Photonic Doppler Velocimetry (PDV) Conference and Workshop held at Sandia National Laboratories, Albuquerque, New Mexico, September 3-4, 2008