TACKLING LOW INCOME AND DEPRIVATION: DEVELOPING EFFECTIVE POLICIES. RESEARCH SERIES NUMBER 1 JUNE 2008

This study examines options for the future development of the Irish welfare state, with a view to tackling low income and deprivation more effectively. It draws on existing national and cross-country evidence as well as providing new analyses to inform policy debate in this area. The impact of alternative policy choices is explored using SWITCH, the ESRI tax-benefit model

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Employment conditions and job satisfaction The distribution, perception and evaluation of job rewards among male employees in Dublin

SIGLEAvailable from British Library Document Supply Centre-DSC:DX192506 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

The convergence in L of the Partial wave expansion for electron-atom collisions

In the partial wave treatment of electron-neutral atome collisions the calculation of converged cross-sections is greatly complicated by the large number of angular momentum states which contribute. Methods of accelerating this convergence are discussed