On the Role of the Research Agenda in Epistemic Change

The standard way of representing an epistemic state in formal philosophy is in terms of a set of sentences, corresponding to the agent's beliefs, and an ordering of those sentences, reflecting how well entrenched they are in the agent's epistemic state. We argue that this wide-spread representational view-a view that we identify as a "Quinean dogma" - is incapable of making certain crucial distinctions. We propose, as a remedy, that any adequate representation of epistemic states must also include the agent's research agenda, i.e., the list of question that are open or closed at any given point in time. If the argument of the paper is sound, a person's questions and practical interests, on the one hand, and her beliefs and theoretical values, on the other, are more tightly interwoven than has previously been assumed to be the case in formal epistemology

Perspectives on the dynamics of third spaces

While coworking spaces (CSs) were traditionally viewed as a necessity for self-employed workers and freelancers, we outline how different users have also adopted the concept, even more so during the pandemic. The range of users has now expanded with employees from all sorts of companies who need to balance remote working with their private lives at home. We indicate avenues for future growth, in particular when the use of a CS becomes a lifestyle choice, and present paths for future research on CS users

Robust design of all-optical PSK regenerator based on phase sensitive amplification

More compact, stable, and efficient configuration of a recently-developed regenerator is presented. The regenerator is assessed at data rates up to 56 Gbit/s using white phase noise for the first time

Exploring the logic of mobile search

After more than a decade of development work and hopes, the usage of mobile Internet has finally taken off. Now, we are witnessing the first signs of evidence of what might become the explosion of mobile content and applications that will be shaping the (mobile) Internet of the future. Similar to the wired Internet, search will become very relevant for the usage of mobile Internet. Current research on mobile search has applied a limited set of methodologies and has also generated a narrow outcome of meaningful results. This article covers new ground, exploring the use and visions of mobile search with a users' interview-based qualitative study. Its main conclusion builds upon the hypothesis that mobile search is sensitive to a mobile logic different than today's one. First, (advanced) users ask for accessing with their mobile devices the entire Internet, rather than subsections of it. Second, success is based on new added-value applications that exploit unique mobile functionalities. The authors interpret that such mobile logic involves fundamentally the use of personalised and context-based services

Histone Deacetylase Inhibitors Prevent Persistent Hypersensitivity in an Orofacial Neuropathic Pain Model

Chronic orofacial pain is a significant health problem requiring identification of regulating processes. Involvement of epigenetic modifications that is reported for hindlimb neuropathic pain experimental models, however, is less well studied in cranial nerve pain models. Three independent observations reported here are the (1) epigenetic profile in mouse trigeminal ganglia (TG) after trigeminal inflammatory compression (TIC) nerve injury mouse model determined by gene expression microarray, (2) H3K9 acetylation pattern in TG by immunohistochemistry, and (3) efficacy of histone deacetylase (HDAC) inhibitors to attenuate development of hypersensitivity. After TIC injury, ipsilateral whisker pad mechanical sensitization develops by day 3 and persists well beyond day 21 in contrast to sham surgery. Global acetylation of H3K9 decreases at day 21 in ipsilateral TG. Thirty-four genes are significantly (p \u3c 0.05) overexpressed in the ipsilateral TG by at least two-fold at either 3 or 21 days post-trigeminal inflammatory compression injury. The three genes most overexpressed three days post-trigeminal inflammatory compression nerve injury are nerve regeneration-associated gene ATF3, up 6.8-fold, and two of its regeneration-associated gene effector genes, Sprr1a and Gal, up 174- and 25-fold, respectively. Although transcription levels of 25 of 32 genes significantly overexpressed three days post-trigeminal inflammatory compression return to constitutive levels by day 21, these three regeneration-associated genes remain significantly overexpressed at the later time point. On day 21, when tissues are healed, other differentially expressed genes include 39 of the top 50 upregulated and downregulated genes. Remarkably, preemptive manipulation of gene expression with two HDAC inhibitors (HDACi\u27s), suberanilohydroxamic acid (SAHA) and MS-275, reduces the magnitude and duration of whisker pad mechanical hypersensitivity and prevents the development of a persistent pain state. These findings suggest that trigeminal nerve injury leads to epigenetic modifications favoring overexpression of genes involved in nerve regeneration and that maintaining transcriptional homeostasis with epigenetic modifying drugs could help prevent the development of persistent pain

QPSK phase and amplitude regeneration at 56 Gbaud in a novel idler-free non-degenerate phase sensitive amplifier

We introduce a novel input-idler-free non-degenerate phase sensitive amplifier (PSA) configuration and use it for simultaneous phase and amplitude regeneration of quadrature phase shift keyed (QPSK) signals demonstrated at symbol rates up to 56 Gbaud

ECU-oriented models for NOx prediction. Part 1: a mean value engine model for NOx prediction

The implantation of nitrogen oxide sensors in diesel engines was proposed in order to track the emissions at the engine exhaust, with applications to the control and diagnosis of the after-treatment devices. However, the use of models is still necessary since the output from these sensors is delayed and filtered. The present paper deals with the problem of nitrogen oxide estimation in turbocharged diesel engines combining the information provided by both models and sensors. In Part 1 of this paper, a control-oriented nitrogen oxide model is designed. The model is based on the mapping of the nitrogen oxide output and a set of corrections which account for the variations in the intake and ambient conditions, and it is designed for implementation in commercial electronic control units. The model is sensitive to variations in the engine's air path, which is solved through the engine volumetric efficiency and the first-principle equations but disregards the effect of variation in the injection settings. In order to consider the effect of the thermal transients on the in-cylinder temperature, the model introduces a dynamic factor. The model behaves well in both steady-state operation and transient operation, achieving a mean average error of 7% in the steady state and lower than 10% in an exigent sportive driving mountain profile cycle. The relatively low calibration effort and the model accuracy show the feasibility of the model for exhaust gas recirculation control as well as onboard diagnosis of the nitrogen oxide emissions.Guardiola, C.; Pla Moreno, B.; Blanco-Rodriguez, D.; Calendini, PO. (2015). ECU-oriented models for NOx prediction. Part 1: a mean value engine model for NOx prediction. Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering. 229(8):992-1015. doi:10.1177/0954407014550191S9921015229

A good practice guide for ethical and inclusive communications involving small-scale fisheries

Today, small-scale fisheries are experiencing substantial climate, economic, and political changes. The power of communications can greatly influence how fisherfolk and small-scale fisheries are central or marginal, enabled or disenabled among these changes. Messages and discourse can shape perspectives on, and images of, small-scale fisheries, leading actors (including those who have power) to hold certain ideas and views on how they should be governed, thereby influencing outcomes. This guide provides practical and simple guidance on how to communicate about small-scale f isheries in an inclusive, responsible and ethical way that respects and recognizes the 120 million women, men and youth employed and engaged in the sector

Intraprocedural MRI-based dosimetry during transarterial radioembolization of liver tumours with holmium-166 microspheres (EMERITUS-1):a phase I trial towards adaptive, image-controlled treatment delivery

PURPOSE: Transarterial radioembolization (TARE) is a treatment for liver tumours based on injection of radioactive microspheres in the hepatic arterial system. It is crucial to achieve a maximum tumour dose for an optimal treatment response, while minimizing healthy liver dose to prevent toxicity. There is, however, no intraprocedural feedback on the dose distribution, as nuclear imaging can only be performed after treatment. As holmium-166 ((166)Ho) microspheres can be quantified with MRI, we investigate the feasibility and safety of performing (166)Ho TARE within an MRI scanner and explore the potential of intraprocedural MRI-based dosimetry. METHODS: Six patients were treated with (166)Ho TARE in a hybrid operating room. Per injection position, a microcatheter was placed under angiography guidance, after which patients were transported to an adjacent 3-T MRI system. After MRI confirmation of unchanged catheter location, (166)Ho microspheres were injected in four fractions, consisting of 10%, 30%, 30% and 30% of the planned activity, alternated with holmium-sensitive MRI acquisition to assess the microsphere distribution. After the procedures, MRI-based dose maps were calculated from each intraprocedural image series using a dedicated dosimetry software package for (166)Ho TARE. RESULTS: Administration of (166)Ho microspheres within the MRI scanner was feasible in 9/11 (82%) injection positions. Intraprocedural holmium-sensitive MRI allowed for tumour dosimetry in 18/19 (95%) of treated tumours. Two CTCAE grade 3–4 toxicities were observed, and no adverse events were attributed to treatment in the MRI. Towards the last fraction, 4/18 tumours exhibited signs of saturation, while in 14/18 tumours, the microsphere uptake patterns did not deviate from the linear trend. CONCLUSION: This study demonstrated feasibility and preliminary safety of a first in-human application of TARE within a clinical MRI system. Intraprocedural MRI-based dosimetry enabled dynamic insight in the microsphere distribution during TARE. This proof of concept yields unique possibilities to better understand microsphere distribution in vivo and to potentially optimize treatment efficacy through treatment personalization. REGISTRATION: Clinicaltrials.gov, identifier NCT04269499, registered on February 13, 2020 (retrospectively registered). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00259-022-05902-w