Myocardial Uptake of Radioactively Labelled Free Fatty Acids

Structural variations in the carbon chain of free fatty acids influence the uptake of free fatty acids in the myocardium. To enable the use of free fatty acids in nuclear cardiology, various methods of introducing gammaemitting isotopes have been evaluated. The uptake of various free fatty acids is described and structure-activity relationships deduce

Accommodating Stealth Assessment in Serious Games:Towards Developing A Generic Tool

Stealth assessment derives the progression of learning in an unobtrusive way from observed gameplay captured in log files. To this end, it uses machine learning technologies to provide probabilistic reasoning over established latent competency variable models. Now that video games are increasingly being used for training and learning purposes, stealth assessment could provide an excellent means of monitoring learning progress without the need for explicit testing. However, applying stealth assessment is a complex and laborious process. This paper analyses the limitations of stealth assessment and conceptualizes the requirements for developing a generic tool that could overcome its barriers and accommodate its practical application. Hence, a framework is presented describing its user and functional requirements. The proposed generic solution could open up the wider uptake of stealth assessment in serious games

Don't blame distributional semantics if it can't do entailment

Distributional semantics has had enormous empirical success in Computational Linguistics and Cognitive Science in modeling various semantic phenomena, such as semantic similarity, and distributional models are widely used in state-of-the-art Natural Language Processing systems. However, the theoretical status of distributional semantics within a broader theory of language and cognition is still unclear: What does distributional semantics model? Can it be, on its own, a fully adequate model of the meanings of linguistic expressions? The standard answer is that distributional semantics is not fully adequate in this regard, because it falls short on some of the central aspects of formal semantic approaches: truth conditions, entailment, reference, and certain aspects of compositionality. We argue that this standard answer rests on a misconception: These aspects do not belong in a theory of expression meaning, they are instead aspects of speaker meaning, i.e., communicative intentions in a particular context. In a slogan: words do not refer, speakers do. Clearing this up enables us to argue that distributional semantics on its own is an adequate model of expression meaning. Our proposal sheds light on the role of distributional semantics in a broader theory of language and cognition, its relationship to formal semantics, and its place in computational models.Horizon 2020(H2020)715154FGW – Publications without University Leiden contrac

Myocardial uptake of radioactively labelled free fatty acids

Structural variations in the carbon chain of free fatty acids influence the uptake of free fatty acids in the myocardium. To enable the use of free fatty acids in nuclear cardiology, various methods of introducing gammaemitting isotopes have been evaluated. The uptake of various free fatty acids is described and structure-activity relationships deduce

Kinetics of Radioiodinated Heptadecanoic Acid and Metabolites in the Normal and Ischaemic Canine Heart

This study was undertaken to elucidate if the myocardial elimination rate of the radioactivity after administration of radioiodinated heptadecanoic acid was related to beta-oxidation of the fatty acid or related to washout of free radioiodide. In samples of normal and ischaemic myocardium the distribution of the radioactivity over free radioiodide, heptadecanoic acid and lipids was determined. In normal myocardium the major component was free radioiodide, only a small percentage being heptadecanoic acid. In ischaemic myocardium more radiolabelled lipids were present and less free iodide when compared with normal myocardium. The percentage heptadecanoic acid was slightly increased. It is concluded that radioiodinated heptadecanoic acid behaves like the natural analogues regarding uptake and distribution. However, washout of free radioiodide determines the elimination rate as observed during a scintigraphic stud

The starburst phenomenon from the optical/near-IR perspective

The optical/near-IR stellar continuum carries unique information about the stellar population in a galaxy, its mass function and star-formation history. Star-forming regions display rich emission-line spectra from which we can derive the dust and gas distribution, map velocity fields, metallicities and young massive stars and locate shocks and stellar winds. All this information is very useful in the dissection of the starburst phenomenon. We discuss a few of the advantages and limitations of observations in the optical/near-IR region and focus on some results. Special attention is given to the role of interactions and mergers and observations of the relatively dust-free starburst dwarfs. In the future we expect new and refined diagnostic tools to provide us with more detailed information about the IMF, strength and duration of the burst and its triggering mechanisms.Comment: 6 pages, 3 figures, to appear in "Starbursts: from 30 Doradus to Lyman Break Galaxies" 2005, eds. R. de Grijs and R. M. Gonzalez Delgado (Kluwer

Virgo cluster early-type dwarf galaxies with the Sloan Digital Sky Survey. II. Early-type dwarfs with central star formation

Despite the common picture of an early-type dwarf (dE) as a quiescent galaxy with no star formation and little gas, we identify 23 dEs that have blue central colors caused by recent or ongoing star formation in our sample of 476 Virgo cluster dEs. In addition, 14 objects that were mostly classified as (candidate) BCDs have similar properties. Among the certain cluster members, the dEs with blue centers reach a fraction of more than 15% of the dE population at brighter (B<=16) magnitudes. A spectral analysis of the centers of 16 galaxies reveals in all cases an underlying old population that dominates the mass, with M(old)>=90% for all but one object. Therefore the majority of these galaxies will appear like ordinary dEs within ~one Gigayear or less after the last episode of star formation. Their overall gas content is less than that of dwarf irregular galaxies, but higher than that of ordinary dEs. Their flattening distribution suggests the shape of a thick disk, similar to what has been found for dEs with disk features in Paper I of this series. Their projected spatial distribution shows no central clustering, and their distribution with projected local density follows that of irregular galaxies, indicative of an unrelaxed population. This is corroborated by their velocity distribution, which displays two side peaks characteristic of recent infall. We discuss possible formation mechanisms (ram-pressure stripping, tidally induced star formation, harassment) that might be able to explain both the disk shape and the central star formation of the dEs with blue centers.Comment: 16 pages + 15 figures. Accepted for publication in AJ. We recommend downloading the full resolution version from http://www.virgo-cluster.com/lisker2006b.ps.g

Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing

Fusion genes are hallmarks of various cancer types and important determinants for diagnosis, prognosis and treatment. Fusion gene partner choice and breakpoint-position promiscuity restricts diagnostic detection, even for known and recurrent configurations. Here, we develop FUDGE (FUsion Detection from Gene Enrichment) to accurately and impartially identify fusions. FUDGE couples target-selected and strand-specific CRISPR-Cas9 activity for fusion gene driver enrichment - without prior knowledge of fusion partner or breakpoint-location - to long read nanopore sequencing with the bioinformatics pipeline NanoFG. FUDGE has flexible target-loci choices and enables multiplexed enrichment for simultaneous analysis of several genes in multiple samples in one sequencing run. We observe on-average 665 fold breakpoint-site enrichment and identify nucleotide resolution fusion breakpoints within 2 days. The assay identifies cancer cell line and tumor sample fusions irrespective of partner gene or breakpoint-position. FUDGE is a rapid and versatile fusion detection assay for diagnostic pan-cancer fusion detection

An Emerging Model of Creative Game-based Learning

We consider the integration of creative approaches to problem solving into pervasive games is a natural extension of play for creative thinking – one that can innovatively drive technology-led changes to the facilitation of creative thinking and pose a new genre in serious gaming for learning. This paper presents an initial proposal of a new model of creative game-base learning (CGBL), which emerged through mapping of established characteristics of climates that encourage creativity and innovation to characteristics of effective serious games