Stability of gene contributions and identification of outliers in multivariate analysis of microarray data

BACKGROUND: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages compared to common gene-by-gene approaches. However, due to their exploratory nature, multivariate ordination methods do not allow direct statistical testing of the stability of genes. RESULTS: In this study, we developed a computationally efficient algorithm for: i) the assessment of the significance of gene contributions and ii) the identification of sample outliers in multivariate analysis of microarray data. The approach is based on the use of resampling methods including bootstrapping and jackknifing. A statistical package of R functions was developed. This package includes tools for both inferring the statistical significance of gene contributions and identifying outliers among samples. CONCLUSION: The methodology was successfully applied to three published data sets with varying levels of signal intensities. Its relevance was compared with alternative methods. Overall, it proved to be particularly effective for the evaluation of the stability of microarray data

Toward Strategic Cohesion : A Reply to King’s Criticism of the Call for a Broader View of Cohesion

In October 2018, Armed Forces & Society published a special issue that called for a theoretical and methodological broadening of the study of cohesion. In a response, King accuses me of ignoring his 2013 book The Combat Soldier, which he feels had already made this call redundant. This answer explains why this is not the case. The Combat Soldier ticks the three boxes of modern, Western, and state military that have dominated the study of cohesion. The resulting narrow vantage point affirms problematic assumptions of Western concepts as absolutes with universal validity with little room for other models of sociopolitical interaction. This becomes especially problematic when King defines cohesion as tactical-level combat performance, the be-all and end-all of what makes, and decides, war. The answer concludes with an appeal for truly interdisciplinary future studies of war that a broader understanding of cohesion, among other things, depends on

Global health philanthropy and institutional relationships: how should conflicts of interest be addressed?

David Stuckler and colleagues examine five large private global health foundations and report on the scope of relationships between these tax-exempt foundations and for-profit corporations including major food and pharmaceutical companies