A review of the influence of physical condition parameters on a typical aerospace stress effect: Decompression sickness

The study examines data on episodes of decompression sickness, particularly from recent Navy work in which the event occurred under multiple stress conditions, to determine the extent to which decompression sickness might be predicted on the basis of personal characteristics such as age, weight, and physical condition. Such information should ultimately be useful for establishing medical selection criteria to screen individuals prior to participation inactivities involving extensive changes in ambient pressure, including those encountered in space operations. The main conclusions were as follows. There is a definite and positive relationship between increasing age and weight and the likelihood of decompression sickness. However, for predictive purposes, the relationship is low. To reduce the risk of bends, particularly for older individuals, strenuous exercise should be avoided immediately after ambient pressure changes. Temperatures should be kept at the low end of the comfort zone. For space activities, pressure changes of over 6-7 psi should be avoided. Prospective participants in future missions such as the Space Shuttle should not be excluded on the basis of age, certainly to age 60, if their general condition is reasonably good and they are not grossly obese. (Modified author abstract

Duality Symmetries and G^{+++} Theories

We show that the non-linear realisations of all the very extended algebras G^{+++}, except the B and C series which we do not consider, contain fields corresponding to all possible duality symmetries of the on-shell degrees of freedom of these theories. This result also holds for G_2^{+++} and we argue that the non-linear realisation of this algebra accounts precisely for the form fields present in the corresponding supersymmetric theory. We also find a simple necessary condition for the roots to belong to a G^{+++} algebra.Comment: 35 pages. v2: 2 appendices added, other minor corrections. v3: tables corrected, other minor changes, one appendix added, refs. added. Version published in Class. Quant. Gra

Aging and Rejuvenation with Fractional Derivatives

We discuss a dynamic procedure that makes the fractional derivatives emerge in the time asymptotic limit of non-Poisson processes. We find that two-state fluctuations, with an inverse power-law distribution of waiting times, finite first moment and divergent second moment, namely with the power index mu in the interval 2<mu <3, yields a generalized master equation equivalent to the sum of an ordinary Markov contribution and of a fractional derivative term. We show that the order of the fractional derivative depends on the age of the process under study. If the system is infinitely old, the order of the fractional derivative, ord, is given by ord=3-mu . A brand new system is characterized by the degree ord=mu -2. If the system is prepared at time -ta<0$ and the observation begins at time t=0, we derive the following scenario. For times 0<t<<ta the system is satisfactorily described by the fractional derivative with ord=3-mu . Upon time increase the system undergoes a rejuvenation process that in the time limit t>>ta yields ord=mu -2. The intermediate time regime is probably incompatible with a picture based on fractional derivatives, or, at least, with a mono-order fractional derivative.Comment: 11 pages, 4 figure

The peculiar velocities of rich clusters in the hot and cold dark matter scenarios

We present the results of a study of the peculiar velocities of rich clusters of galaxies. The peculiar motion of rich clusters in various cosmological scenarios is of interest for a number of reasons. Observationally, one can measure the peculiar motion of clusters to greater distances than galaxies because cluster peculiar motions can be determined to greater accuracy. One can also test the slope of distance indicator relations using clusters to see if galaxy properties vary with environment. We have used N-body simulations to measure the amplitude and rms cluster peculiar velocity as a function of bias parameter in the hot and cold dark matter scenarios. In addition to measuring the mean and rms peculiar velocity of clusters in the two models, we determined whether the peculiar velocity vector of a given cluster is well aligned with the gravity vector due to all the particles in the simulation and the gravity vector due to the particles present only in the clusters. We have investigated the peculiar velocities of rich clusters of galaxies in the cold dark matter and hot dark matter galaxy formation scenarios. We have derived peculiar velocities and associated errors for the scenarios using four values of the bias parameter ranging from b = 1 to b = 2.5. The growth of the mean peculiar velocity with scale factor has been determined and compared to that predicted by linear theory. In addition, we have compared the orientation of force and velocity in these simulations to see if a program such as that proposed by Bertschinger and Dekel (1989) for elliptical galaxy peculiar motions can be applied to clusters. The method they describe enables one to recover the density field from large scale redshift distance samples. The method makes it possible to do this when only radial velocities are known by assuming that the velocity field is curl free. Our analysis suggests that this program if applied to clusters is only realizable for models with a low value of the bias parameter, i.e., models in which the peculiar velocities of clusters are large enough that the errors do not render the analysis impracticable

Single site observations of \textit{TESS} single transit detections

Context: TESS has been successfully launched and has begin data acquisition. To expedite the science that may be performed with the resulting data it is necessary to gain a good understanding of planetary yields. Given the observing strategy employed by TESS the probability of detecting single transits in long period systems is increased. These systems require careful consideration. Aims: To simulate the number of TESS transit detections during its 2 year mission with a particular emphasis on single transits. Additionally, to determine the feasibility of ground-based follow-up observations from a single site. Methods: A distribution of planets is simulated around the $\sim$ 4 million stars in the TESS Candidate Target List. These planets are tested for detectable transits and characterised. Based on simulated parameters the single transit detections are further analysed to determine which are amenable to ground-based follow-up. Results: TESS will discover an approximate lower bound of 4700 planets with around 460 being single transits. A large fraction of these will be observable from a single ground-based site. This paper finds that, in a single year, approximately 1000 transit events of around 320 unique TESS single transit detections are theoretically observable. Conclusions: As we consider longer period exoplanets the need for exploring single transit detections increases. For periods $\gtrsim45$ days the number of single transit detections outnumber multitransits by a factor of 3 (82$\pm$18 and 25$\pm$7 respectively) a factor which only grows as longer period detections are considered. Therefore, it is worth expending the extra effort required to follow-up these more challenging, but potentially very rewarding, discoveries. Additionally, we conclude that a large fraction of these targets can be theoretically observed from just a single ground-based site.Comment: 12 pages, 19 figures. To be published in Astronomy and Astrophysic

Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences

The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1. CDK9 is able to hyperphosphorylate the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase during elongation. In addition to TAK, the transcription elongation factor Spt5 is required for the efficient activation of transcriptional elongation by Tat. To study the role of Spt5 in HIV transcription in more detail, we have developed a three-stage Tat-dependent transcription assay that permits the isolation of active preinitiation complexes, early-stage elongation complexes, and Tat-activated elongation complexes. Spt5 is recruited in the transcription complex shortly after initiation. After recruitment of Tat during elongation through the transactivation response element RNA, CDK9 is activated and induces hyperphosphorylation of Spt5 in parallel to the hyperphosphorylation of the CTD of RNA polymerase II. However, immunodepletion experiments demonstrate that Spt5 is not required for Tat-dependent activation of the kinase. Chase experiments using the Spt5-depleted extracts demonstrate that Spt5 is not required for early elongation. However, Spt5 plays an important role in late elongation by preventing the premature dissociation of RNA from the transcription complex at terminator sequences and reducing the amount of polymerase pausing at arrest sites, including bent DNA sequences. This novel biochemical function of Spt5 is analogous to the function of NusG, an elongation factor found in Escherichia coli that enhances RNA polymerase stability on templates and shows sequence similarity to Spt5

Coma cluster object populations down to M_R~-9.5

This study follows a recent analysis of the galaxy luminosity functions and colour-magnitude red sequences in the Coma cluster (Adami et al. 2007). We analyze here the distribution of very faint galaxies and globular clusters in an east-west strip of $\sim 42 \times 7$ arcmin$^2$ crossing the Coma cluster center (hereafter the CS strip) down to the unprecedented faint absolute magnitude of M$_R \sim -9.5$. This work is based on deep images obtained at the CFHT with the CFH12K camera in the B, R, and I bands. The analysis shows that the observed properties strongly depend on the environment, and thus on the cluster history. When the CS is divided into four regions, the westernmost region appears poorly populated, while the regions around the brightest galaxies NGC 4874 and NGC 4889 (NGC 4874 and NGC 4889 being masked) are dominated by faint blue galaxies. They show a faint luminosity function slope of -2, very significantly different from the field estimates. Results are discussed in the framework of galaxy destruction (which can explain part of the very faint galaxy population) and of structures infalling on to Coma.Comment: To be published in A&

Alignments of the Dominant Galaxies in Poor Clusters

We have examined the orientations of brightest cluster galaxies (BCGs) in poor MKW and AWM clusters and find that, like their counterparts in richer Abell clusters, poor cluster BCGs exhibit a strong propensity to be aligned with the principal axes of their host clusters as well as the surrounding distribution of nearby (< 20/h Mpc) Abell clusters. The processes responsible for dominant galaxy alignments are therefore independent of cluster richness. We argue that these alignments most likely arise from anisotropic infall of material into clusters along large-scale filaments.Comment: 8 pages, 5 figure