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Palaeolimnology of Lake Sapanca and identification of historic earthquake signals, Northern Anatolian Fault Zone (Turkey)
Lake Sapanca is located on a strand of the Northern Anatolian Fault Zone (NAFZ, Turkey), where a series of strong earthquakes (Ms >6.0) have occurred over the past hundred years. Identifying prehistoric
earthquakes in and around Lake Sapanca is key to a better understanding of plate movements along the
NAFZ. This study contributes to the development of palaeolimnological tools to identify past earthquakes
in Lake Sapanca. To this end several promising proxies were investigated, specifically lithology, magnetic
susceptibility, grain size (thin-section and laser analysis), geochemistry, pollen concentration, diatom
assemblages, 137Cs and 210Pb. Sedimentological indicators provided evidence for reworked, turbidite-like
or homogeneous facies (event layers) in several short cores (<45 cm). Other indicators of sediment input
and the historical chronicles available for the area suggest that three of these event layers likely originated
from the AD 1957, 1967 and 1999 earthquakes. Recent changes in sediment deposition and nutrient
levels have also been identified, but are probably not related to earthquakes. This study demonstrates
that a combination of indicators can be used to recognize earthquake-related event layers in cores that encompass a longer period of time
A New Procedure for Evaluating Ground-Motion Models, with Application to Hydraulic-Fracture-Induced Seismicity in the United Kingdom
An essential component of seismic hazard analysis is the prediction of ground shaking (and its uncertainty), using ground-motion models (GMMs). This article proposes a new method to evaluate (i.e., rank) the suitability of GMMs for modeling ground motions in a given region. The method leverages a statistical tool from sensitivity analysis to quantitatively compare predictions of a GMM with underlying observations. We demonstrate the performance of the proposed method relative to several other popular GMM ranking procedures and highlight its advantages, which include its intuitive scoring system and its ability to account for the hierarchical structure of GMMs. We use the proposed method to evaluate the applicability of several GMMs for modeling ground motions from induced earthquakes due to U.K. shale gas development. The data consist of 195 recordings at hypocentral distances (R) less than 10 km for 29 events with local magnitude (ML) greater than 0 that relate to 2018/2019 hydraulic-fracture operations at the Preston New Road shale gas site in Lancashire and 192 R&lt;10 km recordings for 48 ML&gt;0 events induced—within the same geologic formation—by coal mining near New Ollerton, North Nottinghamshire. We examine: (1) the Akkar, Sandikkaya, and Bommer (2014) models for European seismicity; (2) the Douglas et al. (2013) model for geothermal-induced seismicity; and (3) the Atkinson (2015) model for central and eastern North America induced seismicity. We find the Douglas et al. (2013) model to be the most suitable for almost all of the considered ground-motion intensity measures. We modify this model by recomputing its coefficients in line with the observed data, to further improve its accuracy for future analyses of the seismic hazard of interest. This study both advances the state of the art in GMM evaluation and enhances understanding of the seismic hazard related to U.K. shale gas development
Identification of neutral tumor evolution across cancer types
A.S. is supported by The Chris Rokos Fellowship in Evolution and Cancer.
B.W. is supported by the Geoffrey W. Lewis Post-Doctoral Training fellowship.
This work was supported by the Wellcome Trust (105104/Z/14/Z). C.P.B.
acknowledges funding from the Wellcome Trust through a Research Career
Development Fellowship (097319/Z/11/Z). This work was supported by a
Cancer Research UK Career Development Award to T.A.G. M.J.W. is supported
by a UK Medical Research Council student fellowship
The transcript cleavage factor paralogue TFS4 is a potent RNA polymerase inhibitor
TFIIS-like transcript cleavage factors enhance the processivity and fidelity of archaeal and eukaryotic RNA polymerases. Sulfolobus solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into a potent RNA polymerase inhibitor. TFS4 destabilises the TBP-TFB-RNAP pre-initiation complex and inhibits transcription initiation and elongation. All inhibitory activities are dependent on three lysine residues at the tip of the C-terminal zinc ribbon of TFS4; the inhibition likely involves an allosteric component and is mitigated by the basal transcription factor TFEα/β. A chimeric variant of yeast TFIIS and TFS4 inhibits RNAPII transcription, suggesting that the molecular basis of inhibition is conserved between archaea and eukaryotes. TFS4 expression in S. solfataricus is induced in response to infection with the S ulfolobus turreted icosahedral virus. Our results reveal a compelling functional diversification of cleavage factors in archaea, and provide novel insights into transcription inhibition in the context of the host-virus relationship
A filament of dark matter between two clusters of galaxies
It is a firm prediction of the concordance Cold Dark Matter (CDM)
cosmological model that galaxy clusters live at the intersection of large-scale
structure filaments. The thread-like structure of this "cosmic web" has been
traced by galaxy redshift surveys for decades. More recently the Warm-Hot
Intergalactic Medium (WHIM) residing in low redshift filaments has been
observed in emission and absorption. However, a reliable direct detection of
the underlying Dark Matter skeleton, which should contain more than half of all
matter, remained elusive, as earlier candidates for such detections were either
falsified or suffered from low signal-to-noise ratios and unphysical
misalignements of dark and luminous matter. Here we report the detection of a
dark matter filament connecting the two main components of the Abell 222/223
supercluster system from its weak gravitational lensing signal, both in a
non-parametric mass reconstruction and in parametric model fits. This filament
is coincident with an overdensity of galaxies and diffuse, soft X-ray emission
and contributes mass comparable to that of an additional galaxy cluster to the
total mass of the supercluster. Combined with X-ray observations, we place an
upper limit of 0.09 on the hot gas fraction, the mass of X-ray emitting gas
divided by the total mass, in the filament.Comment: Nature, in pres
Theory of Photon Blockade by an Optical Cavity with One Trapped Atom
In our recent paper [1], we reported observations of photon blockade by one
atom strongly coupled to an optical cavity. In support of these measurements,
here we provide an expanded discussion of the general phenomenology of photon
blockade as well as of the theoretical model and results that were presented in
Ref. [1]. We describe the general condition for photon blockade in terms of the
transmission coefficients for photon number states. For the atom-cavity system
of Ref. [1], we present the model Hamiltonian and examine the relationship of
the eigenvalues to the predicted intensity correlation function. We explore the
effect of different driving mechanisms on the photon statistics. We also
present additional corrections to the model to describe cavity birefringence
and ac-Stark shifts. [1] K. M. Birnbaum, A. Boca, R. Miller, A. D. Boozer, T.
E. Northup, and H. J. Kimble, Nature 436, 87 (2005).Comment: 10 pages, 6 figure
Fundamental limitations for quantum and nano thermodynamics
The relationship between thermodynamics and statistical physics is valid in
the thermodynamic limit - when the number of particles becomes very large.
Here, we study thermodynamics in the opposite regime - at both the nano scale,
and when quantum effects become important. Applying results from quantum
information theory we construct a theory of thermodynamics in these limits. We
derive general criteria for thermodynamical state transformations, and as
special cases, find two free energies: one that quantifies the
deterministically extractable work from a small system in contact with a heat
bath, and the other that quantifies the reverse process. We find that there are
fundamental limitations on work extraction from nonequilibrium states, owing to
finite size effects and quantum coherences. This implies that thermodynamical
transitions are generically irreversible at this scale. As one application of
these methods, we analyse the efficiency of small heat engines and find that
they are irreversible during the adiabatic stages of the cycle.Comment: Final, published versio
Garden varieties: how attractive are recommended garden plants to butterflies?
One way the public can engage in insect conservation is through wildlife gardening, including the growing of insect-friendly flowers as sources of nectar. However, plant varieties differ in the types of insects they attract. To determine which garden plants attracted which butterflies, we counted butterflies nectaring on 11 varieties of summer-flowering garden plants in a rural garden in East Sussex, UK. These plants were all from a list of 100 varieties considered attractive to British butterflies, and included the five varieties specifically listed by the UK charity Butterfly Conservation as best for summer nectar. A total of 2659 flower visits from 14 butterfly and one moth species were observed. We performed a principal components analysis which showed contrasting patterns between the species attracted to Origanum vulgare and Buddleia davidii. The “butterfly bush” Buddleia attracted many nymphalines, such as the peacock, Inachis io, but very few satyrines such as the gatekeeper, Pyronia tithonus, which mostly visited Origanum. Eupatorium cannibinum had the highest Simpson’s Diversity score of 0.75, while Buddleia and Origanum were lower, scoring 0.66 and 0.50 respectively. No one plant was good at attracting all observed butterfly species, as each attracted only a subset of the butterfly community. We conclude that to create a butterfly-friendly garden, a variety of plant species are required as nectar sources for butterflies. Furthermore, garden plant recommendations can probably benefit from being more precise as to the species of butterfly they attract
Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools
Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic resonance imaging (fMRI) data set acquired during a passive audio-visual (AV) experiment with common object stimuli. We labeled three group-level independent component (IC) maps as auditory (A), visual (V), and AV, based on their spatial layouts and activation time courses. The overlap between these IC maps served as definition of a distributed network of multisensory candidate regions including superior temporal, ventral occipito-temporal, posterior parietal and prefrontal regions. During an independent second fMRI experiment, we explicitly tested their involvement in AV integration. Activations in nine out of these twelve regions met the max-criterion (A < AV > V) for multisensory integration. Comparison of this approach with a general linear model-based region-of-interest definition revealed its complementary value for multisensory neuroimaging. In conclusion, we estimated functional networks of uni- and multisensory functional connectivity from one dataset and validated their functional roles in an independent dataset. These findings demonstrate the particular value of ICA for multisensory neuroimaging research and using independent datasets to test hypotheses generated from a data-driven analysis
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