TriMinimal Parametrization of the Neutrino Mixing Matrix

Current experimental data on neutrino mixing are very well described by TriBiMaximal mixing. Accordingly, any phenomenological parametrization of the MNSP matrix must build upon TriBiMaximal mixing. We propose one particularly natural parametrization, which we call "TriMinimal". The three small deviations of the PDG angles from their TriBiMaximal values, and the PDG phase, parametrize the TriMinimal mixing matrix. As an important example of the utility of this new parametrization, we present the simple resulting expressions for the flavor-mixing probabilities of atmospheric and astrophysical neutrinos. As no foreseeable experiment will be sensitive to more than second order in the small parameters, we expand these flavor probabilities to second order.Comment: Typos corrected, references added, title changed; matches version appearing in PRL 100, 111801 (2008)

Phase i study of \u27dose-dense\u27 pemetrexed plus carboplatin/radiotherapy for locally advanced non-small cell lung carcinoma.

BACKGROUND: This phase I study investigates the feasibility of carboplatin plus dose-dense (q2-week) pemetrexed given concurrently with radiotherapy (XRT) for locally advanced and oligometastatic non-small cell lung cancer (NSCLC). METHODS: Eligible patients had Stage III or IV (oligometastatic) NSCLC. Patients received XRT to 63 Gy in standard fractionation. Patients received concurrent carboplatin (AUC = 6) during weeks 1 and 5 of XRT, and pemetrexed during weeks 1, 3, 5, and 7 of XRT. The starting dose level (level 1) of pemetrexed was 300 mg/m2. Following the finding of dose limiting toxicity (DLT) in dose level 1, an amended dose level (level 1A) continued pemetrexed at 300 mg/m2, but with involved field radiation instead of extended nodal irradiation. Consolidation consisted of carboplatin (AUC = 6) and pemetrexed (500 mg/m2) q3 weeks × 2 -3 cycles. RESULTS: Eighteen patients were enrolled. Fourteen patients are evaluable for toxicity analysis. Of the initial 6 patients treated on dose level 1, two experienced DLTs (one grade 4 sepsis, one prolonged grade 3 esophagitis). There was one DLT (grade 5 pneumonitis) in the 8 patients treated on dose level 1A. In 16 patients evaluable for response (4 with oligometastatic stage IV disease and 12 with stage III disease), the median follow-up time is 17.8 months. Thirteen of 16 patients had in field local regional response. The actuarial median survival time was 28.6 months in all patients and 34.7 months (estimated) in stage III patients. CONCLUSIONS: Concurrent carboplatin with dose-dense (q2week) pemetrexed at 300 mg/m2 with involved field XRT is feasible and encouraging in patients with locally advanced and oligometastatic NSCLC

The implications of selenium deficiency for wild herbivore conservation: A review

Selenium (Se) is required at a fundamental physiological level in all animals. Adequate levels of Se are necessary for proper bone metabolism, iodine metabolism, immune function, reproductive success, and recruitment. Selenium is a component of enzymes which scavenge oxidative free radicals that would otherwise degrade cell membranes. Severe deficiency results in obvious symptoms such as white muscle disease in ungulates. However, more frequently, deficiency may be chronic and subclinical. Individuals then display no obvious signs of malady, yet performance suffers until their populations decline without apparent cause or through proximate factors which obscure underlying primary factors. Although well known in domestic stock, the link between population performance and Se deficiency in wild populations has been difficult to firmly establish. Confounding factors include the role of vitamin E, which also acts as an antioxidant to mitigate the need for Se under some circumstances; changing Se requirements at changing times in animal life history; changing Se requirements in relation to pollution levels and other factors causing oxidative stress; and the non-uniform distribution of Se in its various chemical forms in the environment. The latter point is especially important to wild populations that have been reduced to remnant portions of their previous range. Here, we have reviewed the literature of Se in wildlife as well as provided an introduction to Se in physiology and Se behavior in the environment for the wildlife researcher and manager. We conclude that unrecognized Se deficiency may often impede optimal population performance, and we provide recommendations for habitat analysis with regard to Se which can be used in future research. Finally, evidence that the amount of available Se in the environment is decreasing from anthropogenic causes is shown.Fil: Fluck, Werner Thomas. Universidad Atlantida Argentina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Smith Flueck, J. M.. Universidad Atlantida Argentina; ArgentinaFil: Mionczynski, J.. No especifíca;Fil: Mincher, B. J.. No especifíca

Probing Spin-Polarized Currents in the Quantum Hall Regime

An experiment to probe spin-polarized currents in the quantum Hall regime is suggested that takes advantage of the large Zeeman-splitting in the paramagnetic diluted magnetic semiconductor zinc manganese selenide (Zn$_{1-x}$Mn$_x$Se). In the proposed experiment spin-polarized electrons are injected by ZnMnSe-contacts into a gallium arsenide (GaAs) two-dimensional electron gas (2DEG) arranged in a Hall bar geometry. We calculated the resulting Hall resistance for this experimental setup within the framework of the Landauer-B\"uttiker formalism. These calculations predict for 100% spininjection through the ZnMnSe-contacts a Hall resistance twice as high as in the case of no spin-polarized injection of charge carriers into a 2DEG for filling factor $\nu=2$. We also investigated the influence of the equilibration of the spin-polarized electrons within the 2DEG on the Hall resistance. In addition, in our model we expect no coupling between the contact and the 2DEG for odd filling factors of the 2DEG for 100% spininjection, because of the opposite sign of the g-factors of ZnMnSe and GaAs.Comment: 7 pages, 5 figure

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion

B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied by the expression of negative costimulatory molecules such as PD-1, CTLA-4, B and T lymphocyte attenuator, and CD5. Following interaction with B cells, T cells were not induced to proliferate, in a process that was dependent on their expression of PD-1 and CTLA-4, but not CD5. In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells

Evidence for shape coexistence in 98^{98}Mo

A $\gamma\gamma$ angular correlation experiment has been performed to investigate the low-energy states of the nucleus $^{98}$Mo. The new data, including spin assignments, multipole mixing ratios and lifetimes reveal evidence for shape coexistence and mixing in $^{98}$Mo, arising from a proton intruder configuration. This result is reproduced by a theoretical calculation within the proton-neutron interacting boson model with configuration mixing, based on microscopic energy density functional theory. The microscopic calculation indicates the importance of the proton particle-hole excitation across the Z=40 sub-shell closure and the subsequent mixing between spherical vibrational and the $\gamma$-soft equilibrium shapes in $^{98}$Mo.Comment: 6 pages, 5 figures, 3 tables; published in Phys. Rev.