1,196 research outputs found
Comparison of simulated longitudinal profiles of hadronic air showers with MASS2 balloon data
The KASKADE and CORSIKA air shower generators are compared to the data
collected by MASS2 balloon experiment in 1991. The test of longitudinal profile
for proton, helium and muon flux production provide good constraints on these
air shower generators. KASKADE and CORSIKA especially with the new simulator
UrQMD for low energies are found to fit these data well. This study is limited
to a comparison of longitudinal profiles and therefore does not provide
constraints on the overall shower development.Comment: to be published in Astroparticle Physic
Strange Particle Production at RHIC
We report STAR measurements of mid-rapidity yields for the ,
, , , , , and
particles in Cu+Cu and Au+Au GeV
collisions. We show that at a given number of participating nucleons, bulk
strangeness production is higher in Cu+Cu collisions compared to Au+Au
collisions at the same center of mass energy, counter to predictions from the
Canonical formalism. We compare both the Cu+Cu and Au+Au yields to AMPT and
EPOS predictions, and find they reproduce key qualitative aspects of the data.
Finally, we investigate other scaling parameters and find bulk strangeness
production for both the measured data and theoretical predictions, scales
better with the number participants that undergo more than one collision.Comment: Conference proceedings for Hot Quarks 2008, 5 pages and 4 figure
The influence of health care spending on life expectancy
Health care expenditures and life expectancy have both been rising in many countries, including in the Netherlands. However, it is unclear to what extent increased health care spending caused the increase in life expectancy. Establishing a causal link between health care expenditures and mortality is difficult for several reasons. In medicine, randomized clinical trials are the gold standard to demonstrate causality and thereby the effectiveness of clinical interventions. However, data from randomized trials are not available to estimate the influence of health care spending on life expectanc
A general T-matrix approach applied to two-body and three-body problems in cold atomic gases
We propose a systematic T-matrix approach to solve few-body problems with
s-wave contact interactions in ultracold atomic gases. The problem is generally
reduced to a matrix equation expanded by a set of orthogonal molecular states,
describing external center-of-mass motions of pairs of interacting particles;
while each matrix element is guaranteed to be finite by a proper
renormalization for internal relative motions. This approach is able to
incorporate various scattering problems and the calculations of related
physical quantities in a single framework, and also provides a physically
transparent way to understand the mechanism of resonance scattering. For
applications, we study two-body effective scattering in 2D-3D mixed dimensions,
where the resonance position and width are determined with high precision from
only a few number of matrix elements. We also study three fermions in a
(rotating) harmonic trap, where exotic scattering properties in terms of mass
ratios and angular momenta are uniquely identified in the framework of
T-matrix.Comment: 14 pages, 4 figure
Source Dimensions in Ultrarelativistic Heavy Ion Collisions
Recent experiments on pion correlations, interpreted as interferometric
measurements of the collision zone, are compared with models that distinguish a
prehadronic phase and a hadronic phase. The models include prehadronic
longitudinal expansion, conversion to hadrons in local kinetic equilibrium, and
rescattering of the produced hadrons. We find that the longitudinal and outward
radii are surprisingly sensitive to the algorithm used for two-body collisions.
The longitudinal radius measured in collisions of 200 GeV/u sulfur nuclei on a
heavy target requires the existence of a prehadronic phase which converts to
the hadronic phase at densities around 0.8-1.0 GeV/fm. The transverse radii
cannot be reproduced without introducing more complex dynamics into the
transverse expansion.Comment: RevTeX 3.0, 28 pages, 6 figures, not included, revised version, major
change is an additional discussion of the classical two-body collision
algorithm, a (compressed) postscript file of the complete paper including
figures can be obtained from Authors or via anonymous ftp at
ftp://ftp_int.phys.washington.edu/pub/herrmann/pisource.ps.
Soliton back-action evading measurement using spectral filtering
We report on a back-action evading (BAE) measurement of the photon number of
fiber optical solitons operating in the quantum regime. We employ a novel
detection scheme based on spectral filtering of colliding optical solitons. The
measurements of the BAE criteria demonstrate significant quantum state
preparation and transfer of the input signal to the signal and probe outputs
exiting the apparatus, displaying the quantum-nondemolition (QND) behavior of
the experiment.Comment: 5 pages, 5 figure
Scale-free static and dynamical correlations in melts of monodisperse and Flory-distributed homopolymers: A review of recent bond-fluctuation model studies
It has been assumed until very recently that all long-range correlations are
screened in three-dimensional melts of linear homopolymers on distances beyond
the correlation length characterizing the decay of the density
fluctuations. Summarizing simulation results obtained by means of a variant of
the bond-fluctuation model with finite monomer excluded volume interactions and
topology violating local and global Monte Carlo moves, we show that due to an
interplay of the chain connectivity and the incompressibility constraint, both
static and dynamical correlations arise on distances . These
correlations are scale-free and, surprisingly, do not depend explicitly on the
compressibility of the solution. Both monodisperse and (essentially)
Flory-distributed equilibrium polymers are considered.Comment: 60 pages, 49 figure
EFFICACY OF ALIROCUMAB IN 1,191 PATIENTS WITH A WIDE SPECTRUM OF MUTATIONS IN GENES CAUSATIVE FOR FAMILIAL HYPERCHOLESTEROLEMIA
Background Mutation(s) in genes involved in the low-density lipoprotein receptor (LDLR) pathway are typically the underlying cause of familial hypercholesterolemia. Objective The objective of the study was to examine the influence of genotype on treatment responses with alirocumab. Methods Patients from 6 trials (n = 1191, including 758 alirocumab-treated; Clinicaltrials.gov identifiers: NCT01266876; NCT01507831; NCT01623115; NCT01709500; NCT01617655; NCT01709513) were sequenced for mutations in LDLR , apolipoprotein B ( APOB ), proprotein convertase subtilisin/kexin type 9 ( PCSK9 ), LDLR adaptor protein 1, and signal-transducing adaptor protein 1 genes. New mutations were confirmed by Sanger sequencing. Results One or more specific gene mutations were found in 898 patients (75%): 387 and 437 patients had heterozygous LDLR defective and negative mutations, respectively; 46 had a heterozygous APOB -defective mutation; 8 patients had a heterozygous PCSK9 gain-of-function mutation; 293 (25%) had no identifiable mutation in the genes investigated. LDL cholesterol reductions at Week 24 were generally similar across genotypes: 48.3% (n = 131) and 54.3% (n = 89) in LDLR -defective heterozygotes with alirocumab 75 mg Q2W (with possible increase to 150 mg at Week 12) and 150 mg Q2W, respectively; 49.7% (n = 168) and 60.7% (n = 88) in LDLR -negative heterozygotes; 54.1% (n = 20) and 50.1% (n = 6) in APOB -defective heterozygotes; 60.5% (n = 5) and 94.0% (n = 1) in PCSK9 heterozygotes; and 44.9% (n = 85) and 55.4% (n = 69) in patients with no identified mutations. Overall rates of treatment-emergent adverse events were similar for alirocumab vs controls (placebo in 5 trials, ezetimibe control or atorvastatin calibrator arm in 1 trial), with only a higher rate of injection-site reactions with alirocumab. Conclusions In this large patient cohort, individuals with a wide spectrum of mutations in genes underlying familial hypercholesterolemia responded substantially and similarly to alirocumab treatment
Universal interface width distributions at the depinning threshold
We compute the probability distribution of the interface width at the
depinning threshold, using recent powerful algorithms. It confirms the
universality classes found previously. In all cases, the distribution is
surprisingly well approximated by a generalized Gaussian theory of independant
modes which decay with a characteristic propagator G(q)=1/q^(d+2 zeta); zeta,
the roughness exponent, is computed independently. A functional renormalization
analysis explains this result and allows to compute the small deviations, i.e.
a universal kurtosis ratio, in agreement with numerics. We stress the
importance of the Gaussian theory to interpret numerical data and experiments.Comment: 4 pages revtex4. See also the following article cond-mat/030146
Aging without disorder on long time scales
We study the Metropolis dynamics of a simple spin system without disorder,
which exhibits glassy dynamics at low temperatures. We use an implementation of
the algorithm of Bortz, Kalos and Lebowitz \cite{bortz}. This method turns out
to be very efficient for the study of glassy systems, which get trapped in
local minima on many different time scales. We find strong evidence of aging
effects at low temperatures. We relate these effects to the distribution
function of the trapping times of single configurations.Comment: 8 pages Revtex, 7 figures uuencoded (Revised version: the figures are
now present
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