Fermionization of two distinguishable fermions

In this work we study a system of two distinguishable fermions in a 1D harmonic potential. This system has the exceptional property that there is an analytic solution for arbitrary values of the interparticle interaction. We tune the interaction strength via a magnetic offset field and compare the measured properties of the system to the theoretical prediction. At the point where the interaction strength diverges, the energy and square of the wave function for two distinguishable particles are the same as for a system of two identical fermions. This is referred to as fermionization. We have observed this phenomenon by directly comparing two distinguishable fermions with diverging interaction strength with two identical fermions in the same potential. We observe good agreement between experiment and theory. By adding one or more particles our system can be used as a quantum simulator for more complex few-body systems where no theoretical solution is available

Dose-escalated salvage radiotherapy after radical prostatectomy in high risk prostate cancer patients without hormone therapy: outcome, prognostic factors and late toxicity

Purpose: Evaluation of dose escalated salvage radiotherapy (SRT) in patients after radical prostatectomy (RP) who had never received antihormonal therapy. To investigate prognostic factors of the outcome of SRT and to analyze which patient subsets benefit most from dose escalation. Materials and methods: Between 2002 and 2008, 76 patients were treated in three different dose-groups: an earlier cohort treated with 66 Gy irrespective of pre-RT-characteristics and two later cohorts treated with 70 Gy or 75 Gy depending on pre-RT-characteristics. Biochemical-relapse-free-survival (bRFS), clinical-relapse-free-survival (cRFS) and late toxicity were evaluated. Results: Four-year bRFS and cRFS were 62.5% and 85%. Gleason score <8, positive surgical resection margin (PSRM) and low PSA (<= 0.5 ng/ml) before SRT resulted in higher bRFS. Analysis of the whole group showed no clear dose-outcome relationship. Patients with PSRM, however, had improved bRFS when escalating >66 Gy. While >70 Gy did not improve the overall results, 4-year bRFS for patients with manifest local recurrence in the high-dose group was still comparable to those without manifest local recurrences. No grade 4 and minimal grade 3 gastrointestinal and urinary toxicity were observed. Conclusions: Dose-escalated SRT achieves high biochemical control. The data strongly support the application of at least 70 Gy rather than 66 Gy. They do not prove positive effects of doses >70 Gy but do not disprove them as these doses were only applied to an unfavorable patients selection

Partial inhibition of RNA polymerase I promotes animal health and longevity

Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, age-related impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality

Density profiles and density oscillations of an interacting three-component normal Fermi gas

We use a semiclassical approximation to investigate density variations and dipole oscillations of an interacting three-component normal Fermi gas in a harmonic trap. We consider both attractive and repulsive interactions between different pairs of fermions and study the effect of population imbalance on densities. We find that the density profiles significantly deviate from those of non-interacting profiles and extremely sensitive to interactions and population imbalance. Unlike for a two-component Fermi system, we find density imbalance even for balanced populations. For some range of parameters, one component completely repels from the trap center giving rise a donut shape density profile. Further, we find that the in-phase dipole oscillation frequency is consistent with Kohn's theorem and other two dipole mode frequencies are strongly effected by the interactions and the number of atoms in the harmonic trap.Comment: Total seven pages with five figures. Published versio

Using the third state of matter: high harmonic generation from liquid targets

High harmonic generation on solid and gaseous targets has been proven to be a powerful platform for the generation of attosecond pulses. Here we demonstrate a novel technique for the XUV generation on a smooth liquid surface target in vacuum, which circumvents the problem of low repetition rate and limited shot numbers associated with solid targets, while it maintains some of its merits. We employed atomically smooth, continuous liquid jets of water, aqueous salt solutions and ethanol that allow uninterrupted high harmonic generation due to the coherent wake emission mechanism for over 8 h. It has been found that the mechanism of plasma generation is very similar to that for smooth solid target surfaces. The vapor pressure around the liquid target in our setup has been found to be very low such that the presence of the gas phase around the liquid jet could be neglected

Laser-driven x-ray and proton micro-source and application to simultaneous single-shot bi-modal radiographic imaging

Radiographic imaging with x-rays and protons is an omnipresent tool in basic research and applications in industry, material science and medical diagnostics. The information contained in both modalities can often be valuable in principle, but difficult to access simultaneously. Laser-driven solid-density plasma-sources deliver both kinds of radiation, but mostly single modalities have been explored for applications. Their potential for bi-modal radiographic imaging has never been fully realized, due to problems in generating appropriate sources and separating image modalities. Here, we report on the generation of proton and x-ray micro-sources in laser-plasma interactions of the focused Texas Petawatt laser with solid-density, micrometer-sized tungsten needles. We apply them for bi-modal radiographic imaging of biological and technological objects in a single laser shot. Thereby, advantages of laser-driven sources could be enriched beyond their small footprint by embracing their additional unique properties, including the spectral bandwidth, small source size and multi-mode emission. Here the authors show a synchronized single-shot bi-modal x-ray and proton source based on laser-generated plasma. This source can be useful for radiographic and tomographic imaging