A New 95 GHz Methanol Maser Catalog: I. Data

The Purple Mountain Observatory 13.7 m radio telescope has been used to search for 95 GHz (8$_0$--7$_1$A$^+$) class I methanol masers towards 1020 Bolocam Galactic Plane Survey (BGPS) sources, leading to 213 detections. We have compared the line width of the methanol and HCO$^+$ thermal emission in all of the methanol detections and on that basis we find 205 of the 213 detections are very likely to be masers. This corresponds to an overall detection rate of 95 GHz methanol masers towards our BGPS sample of 20%. Of the 205 detected masers 144 (70%) are new discoveries. Combining our results with those of previous 95 GHz methanol masers searches, a total of four hundred and eighty-one 95 GHz methanol masers are now known, we have compiled a catalog listing the locations and properties of all known 95 GHz methanol masers.Comment: 18 pages, 7 figures, 8 tables, accepted for publication in ApJ

Coping with Change: Learning Invariant and Minimum Sufficient Representations for Fine-Grained Visual Categorization

Fine-grained visual categorization (FGVC) is a challenging task due to similar visual appearances between various species. Previous studies always implicitly assume that the training and test data have the same underlying distributions, and that features extracted by modern backbone architectures remain discriminative and generalize well to unseen test data. However, we empirically justify that these conditions are not always true on benchmark datasets. To this end, we combine the merits of invariant risk minimization (IRM) and information bottleneck (IB) principle to learn invariant and minimum sufficient (IMS) representations for FGVC, such that the overall model can always discover the most succinct and consistent fine-grained features. We apply the matrix-based R{\'e}nyi's $\alpha$-order entropy to simplify and stabilize the training of IB; we also design a ``soft" environment partition scheme to make IRM applicable to FGVC task. To the best of our knowledge, we are the first to address the problem of FGVC from a generalization perspective and develop a new information-theoretic solution accordingly. Extensive experiments demonstrate the consistent performance gain offered by our IMS.Comment: Manuscript accepted by CVIU, code is available at Githu

Molecular Bubble and Outflow in S Mon Revealed by Multiband Datasets

We identify a molecular bubble, and study the star formation and its feedback in the S Mon region, using multiple molecular lines, young stellar objects (YSOs), and infrared data. We revisit the distance to S Mon, ~722+/-9 pc, using Gaia Data Release 3 parallaxes of the associated Class II YSOs. The bubble may be mainly driven by a massive binary system (namely 15 Mon), the primary of which is an O7V-type star. An outflow is detected in the shell of the bubble, suggesting ongoing star formation activities in the vicinity of the bubble. The total wind energy of the massive binary star is three orders of magnitude higher than the sum of the observed turbulent energy in the molecular gas and the kinetic energy of the bubble, indicating that stellar winds help to maintain the turbulence in the S Mon region and drive the bubble. We conclude that the stellar winds of massive stars have an impact on their surrounding environment.Comment: 34 pages,19 figures, 5 tables, Accepted for publication in Ap

The impact of job contact networks on wages of rural–urban migrants in China: a switching regression approach

In nationally representative household data from the 2008 Chinese Rural to Urban Migration Survey, nearly two thirds of rural–urban migrants found their employment through family members, relatives, friends or acquaintances. This paper investigates why the use of social network to find jobs is so prevalent among rural–urban migrants in China, and whether migrants face a wage penalty as a result of adopting this job search method. Using a switch regression approach, we find evidence of positive selection effects of the use of networks on wages. Users of networks tend to be older, to have migrated longer ago and to be less educated. In addition, married workers and those from villages with more out-migrant are more likely to use networks, while those without local residential registration status are less likely. Controlling for selectivity, we find a large negative impact of network use on wages. Using job contacts brings access to urban employment, but at the cost of markedly lower wages

Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder

Delayed diagnosis of bipolar disorder (BD) is common. However, diagnostic validity may be enhanced using reliable neurobiological markers for BD. Degree centrality (DC) is one such potential marker that enables researchers to visualize neuronal network abnormalities in the early stages of some neuropsychiatric disorders. In the present study, we measured resting-state DC abnormalities and cognitive deficits in order to identify early neurobiological markers for BD. We recruited 23 patients with BD who had recently experienced manic episodes (duration of illness <2 years) and 46 matched healthy controls. Our findings indicated that patients with BD exhibited DC abnormalities in frontal areas, temporal areas, the right postcentral gyrus, and the posterior lobe of the cerebellum. Moreover, correlation analysis revealed that psychomotor speed indicators were associated with DC in the superior temporal and inferior temporal gyri, while attention indicators were associated with DC in the inferior temporal gyrus, in patients with early BD. Our findings suggest that DC abnormalities in neural emotion regulation circuits are present in patients with early BD, and that correlations between attention/psychomotor speed deficits and temporal DC abnormalities may represent early markers of BD

PgtE Enzyme of Salmonella enterica Shares the Similar Biological Roles to Plasminogen Activator (Pla) in Interacting With DEC-205 (CD205), and Enhancing Host Dissemination and Infectivity by Yersinia pestis

Yersinia pestis, the cause of plague, is a newly evolved Gram-negative bacterium. Through the acquisition of the plasminogen activator (Pla), Y. pestis gained the means to rapidly disseminate throughout its mammalian hosts. It was suggested that Y. pestis utilizes Pla to interact with the DEC-205 (CD205) receptor on antigen-presenting cells (APCs) to initiate host dissemination and infection. However, the evolutionary origin of Pla has not been fully elucidated. The PgtE enzyme of Salmonella enterica, involved in host dissemination, shows sequence similarity with the Y. pestis Pla. In this study, we demonstrated that both Escherichia coli K-12 and Y. pestis bacteria expressing the PgtE-protein were able to interact with primary alveolar macrophages and DEC-205-transfected CHO cells. The interaction between PgtE-expressing bacteria and DEC-205-expressing transfectants could be inhibited by the application of an anti-DEC-205 antibody. Moreover, PgtE-expressing Y. pestis partially re-gained the ability to promote host dissemination and infection. In conclusion, the DEC-205-PgtE interaction plays a role in promoting the dissemination and infection of Y. pestis, suggesting that Pla and the PgtE of S. enterica might share a common evolutionary origin.Peer reviewe

Structure of a Burkholderia pseudomallei Trimeric Autotransporter Adhesin Head

Pathogenic bacteria adhere to the host cell surface using a family of outer membrane proteins called Trimeric Autotransporter Adhesins (TAAs). Although TAAs are highly divergent in sequence and domain structure, they are all conceptually comprised of a C-terminal membrane anchoring domain and an N-terminal passenger domain. Passenger domains consist of a secretion sequence, a head region that facilitates binding to the host cell surface, and a stalk region.Pathogenic species of Burkholderia contain an overabundance of TAAs, some of which have been shown to elicit an immune response in the host. To understand the structural basis for host cell adhesion, we solved a 1.35 A resolution crystal structure of a BpaA TAA head domain from Burkholderia pseudomallei, the pathogen that causes melioidosis. The structure reveals a novel fold of an intricately intertwined trimer. The BpaA head is composed of structural elements that have been observed in other TAA head structures as well as several elements of previously unknown structure predicted from low sequence homology between TAAs. These elements are typically up to 40 amino acids long and are not domains, but rather modular structural elements that may be duplicated or omitted through evolution, creating molecular diversity among TAAs.The modular nature of BpaA, as demonstrated by its head domain crystal structure, and of TAAs in general provides insights into evolution of pathogen-host adhesion and may provide an avenue for diagnostics