11 research outputs found
Building a Housewife's Paradise: Gender, Politics, and American Grocery Stores in the Twentieth Century. By Tracey Deutsch. Chapel Hill: University of North Carolina Press, 2010. 337 pp. Illustrations, tables, bibliography, notes, index. Cloth, $35.00. ISBN: 978-0-807-83327-8.
Ready-to-Wear and Ready-to-Work: A Centry of Industry and Immigrants in Paris and New York. By L. Green. Durham and London: Duke University Press, 1997. Pp. ix, 426. 19.95, paper.
Ready-to-Wear and Ready-to-Work: A Centry of Industry and Immigrants in Paris and New York. By L. Green. Durham and London: Duke University Press, 1997. Pp. ix, 426. 19.95, paper.
Identification of Potent and Selective Aminobipyridyl Inhibitors of Protein Kinase D
The synthesis and biological evaluation of potent and selective PKD inhibitors is described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphology is reported herein