Friends with Benefits: Redefining Personal Gain in Insider Trading Under Salman v. United States

Since Congress has not enacted a statute outlawing insider trading, or the trading of securities based on non-public information, outright, courts have struggled to define what constitutes insider trading. The Supreme Court held that a fiduciary duty was breached when the insider privy to the information receives a “personal benefit.” This Commentary analyzes a pending Supreme Court case, Salman v. United States, which addresses whether pecuniary gain is needed to constitute the personal benefit necessary for insider trading, or if certain relationships are enough for the tip to inherently create a personal benefit for the insider. The author argues that a “personal benefit” can occur when there is (1) a quid pro quo or (2) the relationship between insider and tippee is intimate enough to automatically lead to a benefit for the insider. This conclusion follows Supreme Court precedent and is consistent with the policies for outlawing insider trading

Digital History, Digital Sources, Digital Display: The Her Hat Was in the Ring Project on U.S. Women Who Ran for Political Office Before 1920

In the second half of the nineteenth century and through the first two decades of the twentieth century thousands of women ran for political office on local, state, and national levels throughout the U.S. Due to the principle of federalism, each state decided on voting and electoral rights in their jurisdiction. Thus, prior to 1920 voting rights for women were unevenly applied from state to state. In most women could vote at all. In some states and localities they could vote only for a few offices, such as school board representatives, county officers, and state office holders. In a very few states and territories, where they had been given complete suffrage rights, women could cast ballots for candidates on all levels. Women took up the challenge to run for public office both when they could not vote (relying solely on male voters), and when they finally gained partial or complete suffrage. We estimate that approximately 4,000 women ran in almost 6,000 campaigns by 1920. Currently, our database contains information for 2,300 women, who ran in over 3,000 campaigns. Using traditional and digital resources the Her Hat Was in the Ring project identifies these women candidates providing biographical information for each woman, information about her campaign(s), party affiliation, photographs when available, lists of selected resources, and other aggregate data, via a freely-available, web-based content management system

Digital History, Digital Sources, Digital Display: The Her Hat Was in the Ring Project on U.S. Women Who Ran for Political Office Before 1920

In the second half of the nineteenth century and through the first two decades of the twentieth century thousands of women ran for political office on local, state, and national levels throughout the U.S. Due to the principle of federalism, each state decided on voting and electoral rights in their jurisdiction. Thus, prior to 1920 voting rights for women were unevenly applied from state to state. In most women could vote at all. In some states and localities they could vote only for a few offices, such as school board representatives, county officers, and state office holders. In a very few states and territories, where they had been given complete suffrage rights, women could cast ballots for candidates on all levels. Women took up the challenge to run for public office both when they could not vote (relying solely on male voters), and when they finally gained partial or complete suffrage. We estimate that approximately 4,000 women ran in almost 6,000 campaigns by 1920. Currently, our database contains information for 2,300 women, who ran in over 3,000 campaigns. Using traditional and digital resources the Her Hat Was in the Ring project identifies these women candidates providing biographical information for each woman, information about her campaign(s), party affiliation, photographs when available, lists of selected resources, and other aggregate data, via a freely-available, web-based content management system

Model Demonstration Elementary Classrooms in Northeast Iowa: The Luther College Project

Luther College has a tradition of elementary teacher preparation stretching back to the tum of the century. It was therefore fitting that Luther College receive the only Eisenhower model demonstration program grant given to an Iowa four-year college. Built on outreaches and contacts developed by a teacher enhancement summer workshop held on the Luther Campus in 1993, the new program extends its outreach to the entire Northeast Iowa region

Analysis of Sex-Specific Prostanoid Production Using a Mouse Model of Selective Cyclooxygenase-2 Inhibition

Background: Prostanoids are a family of lipid mediators formed from arachidonic acid by cyclooxygenase enzymes and serve as biomarkers of vascular function. Prostanoid production may be different in males and females indicating that different therapeutic approaches may be required during disease. Objecti ves: We examined sex-dependent differences in COX-related metabolites in genetically modified mice that produce a cyclooxygenase- 2 (COX2) enzyme containing a tyrosine 385 to phenylalanine (Y385F) mutation. This mutation renders the COX2 enzyme unable to form a key intermediate radical required for complete arachidonic acid metabolism and provides a model of selective COX2 inhibition. Design and Methods: Mice heterozygous for the Y385F mutation in COX2 were mated to produce cohorts of wild-type, heterozygous, and COX2 mutant mice. We investigated whether the genotype distribution followed Mendelian genetics and studied whether sex-specific differences could be found in certain prostanoid levels measured in peritoneal macrophages and in urinary samples. Results : The inheritance of the COX2 mutation displayed a significant deviation with respect to Mendel’s laws of genetics, with a lowerthan- expected progeny of weaned COX2 mutant pups. In macrophages, prostaglandin E2 (PGE2) production following lipopolysaccharide (LPS) and interferon gamma (IFNγ) stimulation was COX2-dependent in both males and females, and data indicated that crosstalk between the nitric oxide (NO) and COX2 pathways may be sex specific. We observed significant differences in urinary PGE2 production by male and female COX2 mutant mice, with the loss of COX2 activity in male mice decreasing their ability to produce urinary PGE2. Finally, female mice across all 3 genotypes produced similar levels of urinary thromboxane (measured as 11-dehydro TxB2) at significantly higher levels than males, indicating a sex-related difference that is likely COX1-derived. Conclusions: Our findings clearly demonstrate that sex-related differences in COX-derived metabolites can be observed, and that other pathways (such as the NO pathway) are affected

Application of M13 Phage Display for Identifying Immunogenic Proteins from Tick (\u3cem\u3eIxodes scapularis\u3c/em\u3e) Saliva

Background: Ticks act as vectors for a large number of different pathogens, perhaps most notably Borrelia burgdorferi, the causative agent of Lyme disease. The most prominent tick vector in the United States is the blacklegged tick, Ixodes scapularis. Tick bites are of special public health concern since there are no vaccines available against most tick-transmitted pathogens. Based on the observation that certain non-natural host animals such as guinea pigs or humans can develop adaptive immune responses to tick bites, anti-tick vaccination is a potential approach to tackle health risks associated with tick bites. Results: The aim of this study was to use an oligopeptide phage display strategy to identify immunogenic salivary gland proteins from I. scapularis that are recognized by human immune sera. Oligopeptide libraries were generated from salivary gland mRNA of 18 h fed nymphal I. scapularis. Eight immunogenic oligopeptides were selected using human immune sera. Three selected immunogenic oligopeptides were cloned and produced as recombinant proteins. The immunogenic character of an identified metalloprotease (MP1) was validated with human sera. This enzyme has been described previously and was hypothesized as immunogenic which was confirmed in this study. Interestingly, it also has close homologs in other Ixodes species. Conclusion: An immunogenic protein of I. scapularis was identified by oligopeptide phage display. MP1 is a potential candidate for vaccine development

Variation in Treatment for Trapeziometacarpal Arthrosis

Background: Treatment recommendations for trapeziometacarpal (TMC) arthrosis are highly variable from surgeon to surgeon. This study addressed the influence of viewing radiographs on a decision to offer surgery for TMC arthrosis. Methods: In an online survey, 92 hand surgeons viewed clinical scenarios and were asked if they would offer surgery to 30 patients with TMC arthrosis. Forty-two observers were randomly assigned to review clinical information alone and 50 to review clinical information as well as radiographs. The degree of limitation of daily activities, time since diagnosis, prior treatment, pain with grind, crepitation with grind, and metacarpal adduction with metacarpophalangeal hyperextension were randomized for each patient scenario to determine the influence of these factors on offers of surgery. A cross-classified binary logistic multilevel regression analysis identified factors associated with surgeon offer of surgery. Results: Surgeons were more likely to offer surgery when they viewed radiographs (42% vs. 32%, P = 0.01). Other factors associated variation in offer of surgery included greater limitation of daily activities, symptoms for a year, prior splint or injection, deformity of the metacarpophalangeal joint. Factors not associated included limb dominance, prominence of the TMC joint, crepitation with the grind test, and pinch and grip strength. Conclusion: Surgeons that view radiographs are more likely to offer surgery to people with TMC arthrosis. Surgeons are also more likely to offer surgery when people do not adapt with time and nonoperative treatment. Given the notable influence of surgeon bias, and the potential for surgeon and patient impatience with the adaptation process, methods for increasing patient participation in the decision-making process merit additional attention and study

Subduction Initiation Recorded in the Dadeville Complex of Alabama and Georgia, Southeastern United States

The Dadeville Complex of Alabama and Georgia (southeastern United States) represents the largest suite of exposed mafic-ultramafic rocks in the southern Appalachians. Due to poor preservation, chemical alteration, and tectonic reworking, a specific tectonic origin for the Dadeville Complex has been difficult to deduce. We obtained new whole-rock and mineral geochemistry coupled with zircon U-Pb geochronology to investigate the magmatic and metamorphic processes recorded by the Dadeville Complex, as well as the timing of these processes. Our data reveal an up-stratigraphic evolution in the geochemistry of the volcanic rocks, from forearc basalts to boninites. Our new U-Pb zircon crystallization data—obtained from three amphibolite samples—place the timing of forearc/protoarc volcanism no later than ca. 467 Ma. New thermobarometry suggests that the Dadeville Complex rocks subsequently experienced deep, high-grade metamorphism, at pressure-temperature conditions of \u3e7 kbar and \u3e760 °C. The data presented here support a model for formation of the Dadeville Complex in the forearc region of a subduction zone during subduction initiation and protoarc development, followed by deep burial/underthrusting of the complex during orogenesis

Young solid Earth researchers of the world unite!

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95272/1/eost14667.pd