Status of the ILC Main Linac BPM R&D

An introduction and the status of R&D activities for a high-resolution, "cold" beam position monitor (BPM) and the related read-out electronics are discussed. Two different BPM detector concepts, to be attached to the SC quadrupole and located inside the ILC cryomodule, are currently under investigation: A resonant dipole-mode cavity-style BPM pickup, developed at Fermilab, and a re-entrant resonant coaxial waveguide BPM, designed by CEA-Saclay. While the 1.5 GHz dipole-mode cavity BPM is still in the R&D phase, the re-entrant BPM has already passed first beam tests, including its read-out system. Furthermore, the LAPP group is developing radiation tolerant digital read-out systems, which are tested at the CLIC test facility (CTF).Comment: LCWS / ILC08 conference contribution, 6 pages, 6 figure

Dosimetric implications of the potential radionuclidic impurities in 153Sm-DOTMP

https://openworks.mdanderson.org/articleip/1000/thumbnail.jp

MusE GAs FLOw and Wind (MEGAFLOW) I: First MUSE results on background quasars

The physical properties of galactic winds are one of the keys to understand galaxy formation and evolution. These properties can be constrained thanks to background quasar lines of sight (LOS) passing near star-forming galaxies (SFGs). We present the first results of the MusE GAs FLOw and Wind (MEGAFLOW) survey obtained of 2 quasar fields which have 8 MgII absorbers of which 3 have rest-equivalent width greater than 0.8 \AA. With the new Multi Unit Spectroscopic Explorer (MUSE) spectrograph on the Very Large Telescope (VLT), we detect 6 (75$\%$) MgII host galaxy candidates withing a radius of 30 arcsec from the quasar LOS. Out of these 6 galaxy--quasar pairs, from geometrical arguments, one is likely probing galactic outflows, two are classified as "ambiguous", two are likely probing extended gaseous disks and one pair seems to be a merger. We focus on the wind$-$pair and constrain the outflow using a high resolution quasar spectra from Ultraviolet and Visual Echelle Spectrograph (UVES). Assuming the metal absorption to be due to gas flowing out of the detected galaxy through a cone along the minor axis, we find outflow velocities of the order of $\approx$ 150 km/s (i.e. smaller than the escape velocity) with a loading factor, $\eta =\dot M_{\rm out}/$SFR, of $\approx$ 0.7. We see evidence for an open conical flow, with a low-density inner core. In the future, MUSE will provide us with about 80 multiple galaxy$-$quasar pairs in two dozen fields.Comment: 20 pages, 16 figures, accepted for publication in Ap

Ensaio internacional de trigo - HRAWSN. I avaliação de genótipos de trigo, de origem e provenientes de regiões com alta precipitação pluviométrica, em áreas de terras baixas, 1993.

O trabalho teve como objetivo avaliar uma coleção de genótipos de trigo, provenientes de países com regiões de alta precipitação pluviométrica

Ensaio internacional de trigo - HRAWSN. II avaliação de genótipos de trigo, em áreas de terras baixas, de origem e provenientes de regiões com alta precipitação pluviométrica, 1994.

O presente trabalho teve como objetivo avaliar o comportamento de uma coleção de genótipos de trigo, provenientes de países com regiões com alta precipitação pluviométrica

Erratum to: ‘Early prediction of acute kidney injury after transapical and transaortic aortic valve implantation with urinary G1 cell cycle arrest biomarkers’

Background: Acute kidney injury (AKI) is a common complication following transcatheter aortic valve implantation (TAVI) leading to increased mortality and morbidity. Urinary G1 cell cycle arrest proteins TIMP-2 and IGFBP7 have recently been suggested as sensitive biomarkers for early detection of AKI in critically ill patients. However, the precise role of urinary TIMP-2 and IGFBP7 in patients undergoing TAVI is unknown. Methods: In a prospective observational trial, 40 patients undergoing TAVI (either transaortic or transapical) were enrolled. Serial measurements of TIMP-2 and IGFBP7 were performed in the early post interventional course. The primary clinical endpoint was the occurrence of AKI stage 2/3 according to the KDIGO classification. Results: Now we show, that ROC analyses of [TIMP-2]*[IGFBP7] on day one after TAVI reveals a sensitivity of 100 % and a specificity of 90 % for predicting AKI 2/3 (AUC 0.971, 95 % CI 0.914-1.0, SE 0.0299, p = 0.001, cut-off 1.03). In contrast, preoperative and postoperative serum creatinine levels as well as glomerular filtration rate (GFR) and perioperative change in GFR did not show any association with the development of AKI. Furthermore, [TIMP2]*[IGFBP7] remained stable in patients with AKI = 1, but its levels increased significantly as early as 24 h after TAVI in patients who developed AKI 2/3 in the further course (4.77 +/- 3.21 vs. 0.48 +/- 0.68, p = 0.022). Mean patients age was 81.2 +/- 5.6 years, 16 patients were male (40.0 %). 35 patients underwent transapical and five patients transaortic TAVI. 15 patients (37.5 %) developed any kind of AKI;eight patients (20 %) met the primary endpoint and seven patients required renal replacement therapy (RRT) within 72 h after surgery. Conclusion: Early elevation of urinary cell cycle arrest biomarkers after TAVI is associated with the development of postoperative AKI. [TIMP-2]*[ IGFBP7] provides an excellent diagnostic accuracy in the prediction of AKI that is superior to that of serum creatinine

Radiation Safety Considerations in the Treatment of Canine Skeletal Conditions Using 153Sm, 90Y, and 117mSn

Wendt, Richard E. III; Selting, Kimberly A.; Lattimer, Jimmy C.; Wong, Janine; Simón, Jaime; Stevenson, Nigel R.; Stearns, Stanley D.. Radiation Safety Considerations in the Treatment of Canine Skeletal Conditions Using 153Sm, 90Y, and 117mSn. Health Physics: June 2020 - Volume 118 - Issue 6 - p 702-710 doi: 10.1097/HP.0000000000001222https://openworks.mdanderson.org/mdacc_imgphys_pubs/1001/thumbnail.jp

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages

Oxygen is a critical parameter proposed to modulate the functions of chondrocytes ex-vivo as well as in damaged joints. This article investigates the effect of low (more physiological) oxygen percentage on the biosynthetic and catabolic activity of human articular chondrocytes (HAC) at different phases of in vitro culture

Inter-expert and intra-expert reliability in sleep spindle scoring

Objectives: To measure the inter-expert and intra-expert agreement in sleep spindle scoring, and to quantify how many experts are needed to build a reliable dataset of sleep spindle scorings. Methods: The EEG dataset was comprised of 400 randomly selected 115 s segments of stage 2 sleep from 110 sleeping subjects in the general population (57 ± 8, range: 42–72 years). To assess expert agreement, a total of 24 Registered Polysomnographic Technologists (RPSGTs) scored spindles in a subset of the EEG dataset at a single electrode location (C3-M2). Intra-expert and inter-expert agreements were calculated as F_1-scores, Cohen’s kappa (κ), and intra-class correlation coefficient (ICC). Results: We found an average intra-expert F_1-score agreement of 72 ± 7% (κ: 0.66 ± 0.07). The average inter-expert agreement was 61 ± 6% (κ: 0.52 ± 0.07). Amplitude and frequency of discrete spindles were calculated with higher reliability than the estimation of spindle duration. Reliability of sleep spindle scoring can be improved by using qualitative confidence scores, rather than a dichotomous yes/no scoring system. Conclusions: We estimate that 2–3 experts are needed to build a spindle scoring dataset with ‘substantial’ reliability (κ: 0.61–0.8), and 4 or more experts are needed to build a dataset with ‘almost perfect’ reliability (κ: 0.81–1). Significance: Spindle scoring is a critical part of sleep staging, and spindles are believed to play an important role in development, aging, and diseases of the nervous system

Measures on Banach Manifolds and Supersymmetric Quantum Field Theory

We show how to construct measures on Banach manifolds associated to supersymmetric quantum field theories. These measures are mathematically well-defined objects inspired by the formal path integrals appearing in the physics literature on quantum field theory. We give three concrete examples of our construction. The first example is a family $\mu_P^{s,t}$ of measures on a space of functions on the two-torus, parametrized by a polynomial $P$ (the Wess-Zumino-Landau-Ginzburg model). The second is a family \mu_\cG^{s,t} of measures on a space \cG of maps from $\P^1$ to a Lie group (the Wess-Zumino-Novikov-Witten model). Finally we study a family $\mu_{M,G}^{s,t}$ of measures on the product of a space of connection s on the trivial principal bundle with structure group $G$ on a three-dimensional manifold $M$ with a space of \fg-valued three-forms on $M.$ We show that these measures are positive, and that the measures \mu_\cG^{s,t} are Borel probability measures. As an application we show that formulas arising from expectations in the measures \mu_\cG^{s,1} reproduce formulas discovered by Frenkel and Zhu in the theory of vertex operator algebras. We conjecture that a similar computation for the measures $\mu_{M,SU(2)}^{s,t},$ where $M$ is a homology three-sphere, will yield the Casson invariant of $M.$Comment: Minor correction