Comparison of the safety and efficacy of propofol and dexmedetomidine as sedatives when used as a modified topical formulation

Purpose: To evaluate the safety and efficacy of propofol and dexmedetomidine as sedatives in patients with anticipated difficult airways, used as a modified topical preparation.Methods: A total of 432 patients were enrolled in this study. They were classified as ASA I and ASA II. The patients were equally divided into group A (propofol group) and group B (dexmedetomidine group). A modified Awake Fiberoptic Intubation (AFOI) was carried out for these patients, followed by airway assessment and evaluation of clinical outcome based on intubation scores, adverse events, and postoperative data.Results: Patients in both groups had successful intubation at the first attempt. There was no significant difference in baseline characteristics between the two groups. The SARI scores which characterized the overall score for tracheal intubation were 4.6 and 4.2 for groups A and B, respectively. With respect to rescue infusion and consciousness, 11 patients (5.09 %) in group A required rescue, as against 5 patients (2.31 %) in group B. Seven (7) patients (3.24 %) in group A (propofol group) had severe airway obstruction, while only 4 patients (1.85) in group B had the same adverse reaction. Patients in group B had more satisfactory and favourable outcomes than those in group A who were treated with modified AFOI.Conclusion: The use of dexmedetomidine based on modified topical anaesthesia is safe and comfortable in terms of patient convenience and difficult airway management. Thus, dexmedetomidine is a safe, feasible and effective method for managing difficult airway when applied using the modified AFOI

Impact of exercise training on gut microbiome imbalance in obese individuals: a study based on Mendelian randomization analysis

Objective: The aim of this study was to investigate the relationship between exercise and gut Microbiome and to assess its possible causality.Methods: Using Mendelian randomization (MR) research methods, we collected genetic data from different populations, including genetic variants associated with relative abundance or presence of microbial taxa as instrumental variables. At the same time, we extracted results related to obesity and gut Microbiome from existing relevant studies and used inverse variance weighting (IVW), weighted median, and MR-Egger regression to assess the causal relationship between obesity and gut Microbiome. We plotted forest plots and scatter plots of the association between obesity and gut Microbiome.Results: Gut Microbiome was positively associated with obesity, and four bacterial genera (Akkermansia, RuminococcaceaeUCG011, Holdemania, and Intestinimonas) were associated with obesity according to inverse variance-weighted estimation in at least one MR method. Inverse variance weighted estimation showed that obesity was associated with obesity in Akkermansia (OR = 0.810, 95% CI 0.608–1.079, p = 0.04), RuminococcaceaeUCG011 (OR = 1.238, 95% CI 0. 511–2.999, p = 0.04), Holdemania Intestinimonas (OR = 1.214, 95% CI 1.002–1.470, p = 0.03), and Intestinimonas (OR = 0.747, 95% CI 0.514–1.086, p = 0.01) had a relevant effect. Obesity decreased the abundance of Akkermansia, Intestinimonas microbiome and increased the abundance of RuminococcaceaeUCG011, Holdemania microbiome.Conclusion: The results of this study, conducted using a two-sample Mendelian randomization method, suggest a causal relationship between obesity and intestinal microbiome. Obesity decreased the abundance of Akkermansia, Intestinimonas microbiome and increased the abundance of RuminococcaceaeUCG011, Holdemania microbiome. More randomized controlled trials are necessary to elucidate the protective effects of exercise on gut Microbiome and its unique protective mechanisms

Multiscale spatial patterns of species diversity and biomass together with their correlations along geographical gradients in subalpine meadows.

Researchers frequently discuss spatial distribution patterns of species diversity and biomass together with their correlations along geographical gradients. Typical subalpine meadows occur widely on the east of the Loess Plateau, China; here, we selected nine mountains belonging to four mountain systems from north to south on the east of the plateau. We analyzed five latitudinal and longitudinal gradients together with six elevational gradients to study the spatial distribution patterns of species diversity (including α, β, and γ diversity) and biomass plus with their relationships at various scales. Results showed that (1) for diversity, α-Diversity manifested unimodal variation patterns in horizontal spaces, peaking at high latitude and low longitude. However, α-diversity was not sensitive to elevation in vertical spaces and tended to decrease with increasing elevation. With increased latitude, longitude, and elevation, β-Diversity diminished; meanwhile, the rate of species turnover decreased and the similarity of community composition enlarged. γ-Diversity demonstrated quadratic function changes that were initially incremental and then decreased with increasing longitude, elevation, and latitude from 37.5° to 40°. In general, β-diversity had positive correlation with γ-diversity and negative correlation with α-diversity, which conformed to the function of β = γ/α. (2) For biomass, changes of aboveground biomass (AB) were more obvious along latitudinal gradients, whereas variations of belowground biomass (BB) had smaller differences along longitudinal and latitudinal gradients. More biomass was allocated to BB toward the north and east, whereas root-to-shoot ratio (R/S) was more evident at greater latitude than greater longitude. With increased elevation, more biomass was also allocated to BB, and the relationship of biomass to elevation was closer in AB. In short, the relation of biomass allocation tended to belowground plant parts with different geographical scales. (3) Species diversity had the strongest positive influence on AB. The Patrick and Shannon indices had correlations of power functions with AB and R/S, respectively, indicating that an allometric model could be used to model relationships between species diversity and biomass. In conclusion, the unique geomorphological structures with a series of basins between mountain systems on the east of the Loess Plateau, meant that subalpine meadows were mostly distributed along latitudinal directions, so the spatial distribution of species diversity and biomass was more evident along latitudinal gradients, and thus the response of aboveground biomass was more sensitive to variations of spatial gradients and species diversity

One−Dimensional Seepage of Unsaturated Soil Based on Soil−Water Characteristic Curve

The uneven pore water distribution in unsaturated soil will cause water movement, change the hydraulic and mechanical characteristics of soil, and then cause soil damage. Therefore, it is important to study the hydraulic characteristics of unsaturated soil. In this paper, the law of conservation of mass and Darcy’s law were used to analyze the unit soil after seepage to obtain a continuous equation. Combined with the soil-water characteristic curve (SWCC), the effect of matric suction and permeability coefficient of unsaturated soil on infiltration rate is substituted into the equation. Through the analysis of pore water stress of the unit soil, the function of the unsaturated permeability coefficient with the effective saturation degree is obtained, and the theoretical formula of the one-dimensional infiltration rate of unsaturated soil is derived. Compared with other models, this formula has fewer parameters and is easy to use

Soil Microbial Community Varied with Vegetation Types on a Small Regional Scale of the Qilian Mountains

Clarifying the response of soil microbial communities to the change of different vegetation types on a small regional scale is of great significance for understanding the sustainability of grassland development. However, the distribution patterns and driving factors of the microbial community are not well understood in the Qilian Mountains. Therefore, we characterized and compared the soil microbial communities underlying the four vegetation types in a national natural reserve (reseeded grassland, swamp meadow, steppe meadow, and cultivated grassland) using high-throughput sequencing of the 16S rRNA and ITS. Meanwhile, the plant community and soil physicochemical characteristics were also determined. The results showed that bacterial and fungal communities in all vegetation types had the same dominant species, but the relative abundance differed substantially, which caused significant spatial heterogeneities on the small regional scale. Specifically, bacteria showed higher variability among different vegetation types than fungi, among which the bacterial and fungal communities were more sensitive to the changes in soil than to plant characteristics. Furthermore, soil organic carbon affected the widest portion of the microbial community, nitrate-nitrogen was the main factor affecting bacteria, and aboveground plant biomass was the main factor affecting fungi. Collectively, these results demonstrate the value of considering multiple small regional spatial scales when studying the relationship between the soil microbial community and environmental characteristics. Our study may have important implications for grassland management following natural disturbances or human alterations

Electrochemical and Mechanical Properties of Cathodically Protected X80 Steel in Different Temperature Soil

For the application of X80 pipelines in Northeast China, it is important to establish the correct cathodic protection (CP) potential. To achieve this, potentiodynamic polarization; electrochemical impedance spectroscopy (EIS); a slow strain rate test (SSRT); and a scanning electron microscopy (SEM) fracture morphology analysis were carried out for an X80 steel gas pipeline at several temperatures in Heilongjiang Province, China. The results show that the hydrogen evolution potential of X80 steel in soil at different temperatures was about −900 mV (vs. CSE). The generated hydrogen atoms can be adsorbed on the surface of the pipelines to reduce the surface energy, or they can be diffused into the substrate and accumulate to the critical concentration, inducing the decohesion between different structures and generating additional plastic deformation through dislocation motion. With the peak impedance potential as the minimum potential and the hydrogen embrittlement potential as the maximum potential, the CP potential of X80 steel in the soil at 30 °C, 45 °C, and 60 °C ranged from −900 mV to −1100 mV (vs. CSE), temperatures at which the X80 steel does not corrode or cause hydrogen embrittlement