6,162 research outputs found
Body composition, IGF1 status, and physical functionality in nonagenarians: implications for osteosarcopenia
OBJECTIVES:
Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old.
SETTING AND PARTICIPANTS:
Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included.
MEASURES:
The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1-Standard Deviation Scores (SDS) were calculated. The Continuous Scale-Physical Functional Performance (CS-PFP) test was performed.
RESULTS:
In OS men, IGF1-SDS values (-0.61 ±0.37 vs -0.04 ± 0.52, P = .02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P = .01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women.
CONCLUSIONS/IMPLICATIONS:
IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria
High ions towards white dwarfs: circumstellar line shifts and stellar temperature
Based on a compilation of OVI, CIV, SiIV and NV data from IUE, FUSE, GHRS,
STIS, and COS, we derive an anti- correlation between the stellar temperature
and the high ion velocity shift w.r.t. to the photosphere, with positive (resp.
negative) velocity shifts for the cooler (resp. hotter) white dwarfs. This
trend probably reflects more than a single process, however such a dependence
on the WD's temperature again favors a CS origin for a very large fraction of
those ion absorptions, previously observed with IUE, HST-STIS, HST-GHRS, FUSE,
and now COS, selecting objects for which absorption line radial velocities,
stellar effective temperature and photospheric velocity can be found in the
literature. Interestingly, and gas in near-equilibrium in the star vicinity. It
is also probably significant that the temperature that corresponds to a null
radial velocity, i.e. \simeq 50,000K, also corresponds to the threshold below
which there is a dichotomy between pure or heavy elements atmospheres as well
as some temperature estimates for and a form of balance between radiation
pressure and gravitation. This is consistent with ubiquitous evaporation of
orbiting dusty material. Together with the fact that the fraction of stars with
(red-or blue-) shifted lines and the fraction of stars known to possess heavy
species in their atmosphere are of the same order, such a velocity-temperature
relationship is consistent with quasi-continuous evaporation of orbiting CS
dusty material, followed by accretion and settling down in the photosphere. In
view of these results, ion measurements close to the photospheric or the IS
velocity should be interpreted with caution, especially for stars at
intermediate temperatures. While tracing CS gas, they may be erroneously
attributed to photospheric material or to the ISM, explaining the difficulty of
finding a coherent pattern of the high ions in the local IS 3D distribution.Comment: Accepted by A&A. Body of paper identical to v1. This submission has a
more appropriate truncation of the original abstrac
Improving well-being and outcomes for looked after children in Wales: a context sensitive review of interventions
Improving outcomes for looked after children and young people has been a longstanding concern in Wales. This article reports the findings of a scoping study which sought to identify interventions aimed at improving outcomes for looked after children that are effective or promising. The study was commissioned by an independent funding body to inform a £5 million investment programme for Wales. It comprised a rapid review of literature, informed through consultation with an expert advisory panel and groups of young people who had been in care. The article outlines the rapid review method, provides details of shortlisted interventions and describes the interventions subsequently approved for investment. It concludes that although there are many promising interventions which address the factors associated with poor outcomes for looked after children, the evidence base is weak. It is argued that decision-making on interventions should be informed by appraisal of the empirical evidence available, but should also be guided by professional judgement that considers the needs, priorities and preferences of service users, carers, practitioners and policy-makers
On the fundamental group of the complement of a complex hyperplane arrangement
We construct two combinatorially equivalent line arrangements in the complex
projective plane such that the fundamental groups of their complements are not
isomorphic. The proof uses a new invariant of the fundamental group of the
complement to a line arrangement of a given combinatorial type with respect to
isomorphisms inducing the canonical isomorphism of the first homology groups.Comment: 12 pages, Latex2e with AMSLaTeX 1.2, no figures; this last version is
almost the same as published in Functional Analysis and its Applications 45:2
(2011), 137-14
Spanning Trees on Lattices and Integration Identities
For a lattice with vertices and dimension equal or higher
than two, the number of spanning trees grows asymptotically
as in the thermodynamic limit. We present exact integral
expressions for the asymptotic growth constant for spanning trees
on several lattices. By taking different unit cells in the calculation, many
integration identities can be obtained. We also give on the
homeomorphic expansion of -regular lattices with vertices inserted on
each edge.Comment: 15 pages, 3 figures, 1 tabl
Cavitation-induced force transition in confined viscous liquids under traction
We perform traction experiments on simple liquids highly confined between
parallel plates. At small separation rates, we observe a simple response
corresponding to a convergent Poiseuille flow. Dramatic changes in the force
response occur at high separation rates, with the appearance of a force plateau
followed by an abrupt drop. By direct observation in the course of the
experiment, we show that cavitation accounts for these features which are
reminiscent of the utmost complex behavior of adhesive films under traction.
Surprisingly enough, this is observed here in purely viscous fluids.Comment: Submitted to Physical Review Letters on May 31, 2002. Related
informations on http://www.crpp.u-bordeaux.fr/tack.htm
The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that is further metabolized to dTTP for DNA synthesis. Loss of viability following TS inhibition occurs as a consequence of depleted dTTP pools and at least in some cell lines, accumulation of dUTP and subsequent misincorporation of uracil into DNA. The expansion in dUTP pools is largely determined by the expression of the pyrophosphatase, dUTPase. Our previous work has shown that following TS inhibition the ability to accumulate dUTP was associated with an earlier growth inhibitory effect. 3 human lung tumour cell lines and HT29 human colon tumour cells transfected with dUTPase have been used to investigate the relationship between loss of viability following TS inhibition and dUTP accumulation. Cell cycle arrest typical of TS inhibition was an early event in all cell lines and occurred irrespective of the ability to accumulate dUTP or p53 function. However, a large expansion of dUTP pools was associated with mature DNA damage (4 h) and an earlier loss of viability following TS inhibition compared to cells in which dUTP pools were not expanded. In A549 cells damage to mature DNA may have been exacerbated by significantly higher activity of the excision repair enzyme, uracil-DNA glycosylase. Consistent with results using different inhibitors of TS, transfection of dUTPase into HT29 cells significantly reduced the cytotoxicity of a 24 h but not 48 h exposure to ZD9331. Although loss of viability can be mediated through dTTP deprivation alone, the uracil misincorporation pathway resulted in an earlier commitment to cell death. The relevance of this latter pathway in the clinical response to TS inhibitors deserves further investigation. © 2001 Cancer Research Campaign http://www.bjcancer.co
Hubble Space Telescope Observations of UV Oscillations in WZ Sagittae During the Decline from Outburst
We present a time series analysis of Hubble Space Telescope observations of
WZ Sge obtained in 2001 September, October, November and December as WZ Sge
declined from its 2001 July superoutburst. Previous analysis of these data
showed the temperature of the white dwarf decreased from ~29,000 K to ~18,000
K. In this study we binned the spectra over wavelength to yield ultraviolet
light curves at each epoch that were then analyzed for the presence of the
well-known 27.87 s and 28.96 s oscillations. We detect the 29 s periodicity at
all four epochs, but the 28 s periodicity is absent. The origin of these
oscillations has been debated since their discovery in the 1970s and competing
hypotheses are based on either white dwarf non-radial g-mode pulsations or
magnetically-channelled accretion onto a rotating white dwarf. By analogy with
the ZZ Ceti stars, we argue that the non-radial g-mode pulsation model demands
a strong dependence of pulse period on the white dwarf's temperature. However,
these observations show the 29 s oscillation is independent of the white
dwarf's temperature. Thus we reject the white dwarf non-radial g-mode pulsation
hypothesis as the sole origin of the oscillations. It remains unclear if
magnetically-funnelled accretion onto a rapidly rotating white dwarf (or belt
on the white dwarf) is responsible for producing the oscillations. We also
report the detection of a QPO with period ~18 s in the September light curve.
The amplitudes of the 29 s oscillation and the QPO vary erratically on short
timescales and are not correlated with the mean system brightness nor with each
other.Comment: 20 pages, 3 figures, 1 table; accepted for publication in Ap
- …