16,101 research outputs found
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and putamen, saturation analysis of specific receptor binding was performed for the total number of muscarinic receptors with [3H]quinuclidinyl benzilate, for muscarinic M1 receptors with [3H]pirenzepine, for muscarinic M2 receptors with [3H]oxotremorine-M, and for nicotinic receptors with (-)-[3H]nicotine. In comparison with control tissues, choline acetyl-transferase activity was reduced in the frontal cortex and hippocampus and unchanged in the caudate nucleus and putamen of parkinsonian patients. In Parkinson's disease the maximal binding site density for [3H]quinuclidinyl benzilate was increased in the frontal cortex and unaltered in the hippocampus, caudate nucleus, and putamen. Specific [3H]pirenzepine binding was increased in the frontal cortex, unaltered in the hippocampus, and decreased in the caudate nucleus and putamen. In parkinsonian patients Bmax values for specific [3H]oxotremorine-M binding were reduced in the cortex and unchanged in the hippocampus and striatum compared with controls. Maximal (-)-[3H]nicotine binding was reduced in both the cortex and hippocampus and unaltered in both the caudate nucleus and putamen. Alterations of the equilibrium dissociation constant were not observed for any ligand in any of the brain areas examined. The present results suggest that both the innominatocortical and the septohippocampal cholinergic systems degenerate in Parkinson's disease.(ABSTRACT TRUNCATED AT 250 WORDS
An experimental study of the temporal statistics of radio signals scattered by rain
A fixed-beam bistatic CW experiment designed to measure the temporal statistics of the volume reflectivity produced by hydrometeors at several selected altitudes, scattering angles, and at two frequencies (3.6 and 7.8 GHz) is described. Surface rain gauge data, local meteorological data, surveillance S-band radar, and great-circle path propagation measurements were also made to describe the general weather and propagation conditions and to distinguish precipitation scatter signals from those caused by ducting and other nonhydrometeor scatter mechanisms. The data analysis procedures were designed to provide an assessment of a one-year sample of data with a time resolution of one minute. The cumulative distributions of the bistatic signals for all of the rainy minutes during this period are presented for the several path geometries
Implications of gauge-mediated supersymmetry breaking with vector-like quarks and a ~125 GeV Higgs boson
We investigate the implications of models that achieve a Standard Model-like
Higgs boson of mass near 125 GeV by introducing additional TeV-scale
supermultiplets in the vector-like 10+\bar{10} representation of SU(5), within
the context of gauge-mediated supersymmetry breaking. We study the resulting
mass spectrum of superpartners, comparing and contrasting to the usual
gauge-mediated and CMSSM scenarios, and discuss implications for LHC
supersymmetry searches. This approach implies that exotic vector-like fermions
t'_{1,2}, b',and \tau' should be within the reach of the LHC. We discuss the
masses, the couplings to electroweak bosons, and the decay branching ratios of
the exotic fermions, with and without various unification assumptions for the
mass and mixing parameters. We comment on LHC prospects for discovery of the
exotic fermion states, both for decays that are prompt and non-prompt on
detector-crossing time scales.Comment: 32 pages. v2: references added, figure caption 5.3 correcte
A study of weather-dependent data links for deep space applications
Weather-dependent data links for deep space applications, and five potential system
Gravity anomaly detection: Apollo/Soyuz
The Goddard Apollo-Soyuz Geodynamics Experiment is described. It was performed to demonstrate the feasibility of tracking and recovering high frequency components of the earth's gravity field by utilizing a synchronous orbiting tracking station such as ATS-6. Gravity anomalies of 5 MGLS or larger having wavelengths of 300 to 1000 kilometers on the earth's surface are important for geologic studies of the upper layers of the earth's crust. Short wavelength Earth's gravity anomalies were detected from space. Two prime areas of data collection were selected for the experiment: (1) the center of the African continent and (2) the Indian Ocean Depression centered at 5% north latitude and 75% east longitude. Preliminary results show that the detectability objective of the experiment was met in both areas as well as at several additional anomalous areas around the globe. Gravity anomalies of the Karakoram and Himalayan mountain ranges, ocean trenches, as well as the Diamantina Depth, can be seen. Maps outlining the anomalies discovered are shown
Research Notes: Interactions of cultural practices with insect-induced stress on soybeans
Numerous reports exist which characterize yield loss and defoliation relationships. Management guidelines and decisions regarding defoliating pests have been based largely upon findings from one or more of those studies . The use of such studies as decision-making criteria may be limited since most defoliation yield-related research has been conducted in the Midwest with varieties , growth habits and environmental conditions widely divergent from those found in other areas of production
All-sky Relative Opacity Mapping Using Night Time Panoramic Images
An all-sky cloud monitoring system that generates relative opacity maps over
many of the world's premier astronomical observatories is described.
Photometric measurements of numerous background stars are combined with
simultaneous sky brightness measurements to differentiate thin clouds from sky
glow sources such as air glow and zodiacal light. The system takes a continuous
pipeline of all-sky images, and compares them to canonical images taken on
other nights at the same sidereal time. Data interpolation then yields
transmission maps covering almost the entire sky. An implementation of this
system is currently operating through the Night Sky Live network of CONCAM3s
located at Cerro Pachon (Chile), Mauna Kea (Hawaii), Haleakala (Hawaii), SALT
(South Africa) and the Canary Islands (Northwestern Africa).Comment: Accepted for publication in PAS
Measurement of the charged pion mass using X-ray spectroscopy of exotic atoms
The transitions in pionic nitrogen and muonic oxygen were measured
simultaneously by using a gaseous nitrogen-oxygen mixture at 1.4\,bar. Due to
the precise knowledge of the muon mass the muonic line provides the energy
calibration for the pionic transition. A value of
(139.57077\,\,0.00018)\,MeV/c (\,1.3ppm) is derived for the
mass of the negatively charged pion, which is 4.2ppm larger than the present
world average
A photometricity and extinction monitor at the Apache Point Observatory
An unsupervised software ``robot'' that automatically and robustly reduces
and analyzes CCD observations of photometric standard stars is described. The
robot measures extinction coefficients and other photometric parameters in real
time and, more carefully, on the next day. It also reduces and analyzes data
from an all-sky camera to detect clouds; photometric data taken
during cloudy periods are automatically rejected. The robot reports its
findings back to observers and data analysts via the World-Wide Web. It can be
used to assess photometricity, and to build data on site conditions. The
robot's automated and uniform site monitoring represents a minimum standard for
any observing site with queue scheduling, a public data archive, or likely
participation in any future National Virtual Observatory.Comment: accepted for publication in A
Acromegaly, Mr Punch and caricature.
The origin of Mr Punch from the Italian Pulcinella of the Commedia dell'arte is well known but his feature, large hooked nose, protruding chin, kyphosis and sternal protrusion all in an exaggerated form also suggest the caricature of an acromegalic. This paper looks at the physical characteristics of acromegaly, the origin of Mr Punch and the development of caricature linking them together in the acromegalic caricature that now has a life of its own
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