112 research outputs found
The Use of Disposable Chlorhexidine Wipes Compared to Traditional Bed Bath
https://scholarworks.moreheadstate.edu/student_scholarship_posters/1218/thumbnail.jp
Two Candidates for Dual AGN in Dwarf-Dwarf Galaxy Mergers
Dual AGN are important for understanding galaxy-merger-triggered fueling of
black holes and hierarchical growth of structures. The least explored type of
dual AGN are those associated with mergers of two dwarf galaxies. According to
observations and cosmological simulations, dwarf galaxies are the most abundant
type of galaxies in the early Universe and the galaxy merger rate is dominated
by dwarfs. However, these mergers are generally too distant to be directly
observed, and low-redshift dwarf-dwarf merger-related dual AGN are notoriously
hard to find. In this paper, we present the first results of our large-scale
search for this elusive type of object and the first two candidates for dual
AGN in dwarf-dwarf mergers. Both objects exhibit tidal features (tails and
bridges) characteristic of galaxy mergers/interactions. One object is
apparently in a late-stage merger with an AGN separation of < 5kpc, while the
second is in an early-stage merger with interacting galaxies having established
a tidal bridge. Both objects have dual, luminous X-ray sources that are most
likely due to actively accreting massive black holes. Also, both objects have
infrared counterparts, with colors consistent with being AGN. Follow-up
observations will provide us a glimpse into key processes that govern the
earliest phases of growth of galaxies, their central black holes, and
merger-induced star formation.Comment: Accepted for publication in ApJ. 14 pages, 7 figures, 3 table
Acceleration of Enterococcus faecalis Biofilm Formation by Aggregation Substance Expression in an Ex Vivo Model of Cardiac Valve Colonization
Infectious endocarditis involves formation of a microbial biofilm in vivo. Enterococcus faecalis Aggregation Substance (Asc10) protein enhances the severity of experimental endocarditis, where it has been implicated in formation of large vegetations and in microbial persistence during infection. In the current study, we developed an ex vivo porcine heart valve adherence model to study the initial interactions between Asc10+ and Asc10ā E. faecalis and valve tissue, and to examine formation of E. faecalis biofilms on a relevant tissue surface. Scanning electron microscopy of the infected valve tissue provided evidence for biofilm formation, including growing masses of bacterial cells and the increasing presence of exopolymeric matrix over time; accumulation of adherent biofilm populations on the cardiac valve surfaces during the first 2ā4 h of incubation was over 10-fold higher than was observed on abiotic membranes incubated in the same culture medium. Asc10 expression accelerated biofilm formation via aggregation between E. faecalis cells; the results also suggested that in vivo adherence to host tissue and biofilm development by E. faecalis can proceed by Asc10-dependent or Asc10-independent pathways. Mutations in either of two Asc10 subdomains previously implicated in endocarditis virulence reduced levels of adherent bacterial populations in the ex vivo system. Interference with the molecular interactions involved in adherence and initiation of biofilm development in vivo with specific inhibitory compounds could lead to more effective treatment of infectious endocarditis
Case Study of Resilient Baton Rouge: Applying Depression Collaborative Care and Community Planning to Disaster Recovery.
BackgroundAddressing behavioral health impacts of major disasters is a priority of increasing national attention, but there are limited examples of implementation strategies to guide new disaster responses. We provide a case study of an effort being applied in response to the 2016 Great Flood in Baton Rouge.MethodsResilient Baton Rouge was designed to support recovery after major flooding by building local capacity to implement an expanded model of depression collaborative care for adults, coupled with identifying and responding to local priorities and assets for recovery. For a descriptive, initial evaluation, we coupled analysis of documents and process notes with descriptive surveys of participants in initial training and orientation, including preliminary comparisons among licensed and non-licensed participants to identify training priorities.ResultsWe expanded local behavioral health service delivery capacity through subgrants to four agencies, provision of training tailored to licensed and non-licensed providers and development of advisory councils and partnerships with grassroots and government agencies. We also undertook initial efforts to enhance national collaboration around post-disaster resilience.ConclusionOur partnered processes and lessons learned may be applicable to other communities that aim to promote resilience, as well as planning for and responding to post-disaster behavioral health needs
Texting during lecture...maybe or maybe not?
Media distractions constantly break our attention. In previous research, students attempted to multitask during a five min PowerPoint presentation. The results revealed that participants who did not multitask completed the tasks better than those who did multitask. From these findings, further research designed to study the effects of multitasking on learning is warranted. Therefore, the proposed study consisted of examining the effects of multitasking on memory among college students while simulating texting during a video lecture. The results of the study will provide insight into college studentsā ability to divide their attention between content on their devices and class lectures
JWST MIRI flight performance: The Medium-Resolution Spectrometer
The Medium-Resolution Spectrometer (MRS) provides one of the four operating
modes of the Mid-Infrared Instrument (MIRI) on board the James Webb Space
Telescope (JWST). The MRS is an integral field spectrometer, measuring the
spatial and spectral distributions of light across the 5-28 wavelength
range with a spectral resolving power between 3700-1300. We present the MRS's
optical, spectral, and spectro-photometric performance, as achieved in flight,
and we report on the effects that limit the instrument's ultimate sensitivity.
The MRS flight performance has been quantified using observations of stars,
planetary nebulae, and planets in our Solar System. The precision and accuracy
of this calibration was checked against celestial calibrators with well-known
flux levels and spectral features. We find that the MRS geometric calibration
has a distortion solution accuracy relative to the commanded position of 8 mas
at 5 and 23 mas at 28 . The wavelength calibration is accurate
to within 9 km/sec at 5 and 27 km/sec at 28 . The uncertainty in
the absolute spectro-photometric calibration accuracy was estimated at 5.6 +-
0.7 %. The MIRI calibration pipeline is able to suppress the amplitude of
spectral fringes to below 1.5 % for both extended and point sources across the
entire wavelength range. The MRS point spread function (PSF) is 60 % broader
than the diffraction limit along its long axis at 5 and is 15 % broader
at 28 . The MRS flight performance is found to be better than prelaunch
expectations. The MRS is one of the most subscribed observing modes of JWST and
is yielding many high-profile publications. It is currently humanity's most
powerful instrument for measuring the mid-infrared spectra of celestial sources
and is expected to continue as such for many years to come.Comment: 16 pages, 21 figure
Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification
Effective approaches for assessing mitochondrial DNA (mtDNA) variation are important to multiple scientific disciplines. Mitochondrial haplogroups characterize branch points in the phylogeny of mtDNA. Several tools exist for mitochondrial haplogroup classification. However, most require full or partial mtDNA sequence which is often cost prohibitive for studies with large sample sizes. The purpose of this study was to develop Hi-MC, a high-throughput method for mitochondrial haplogroup classification that is cost effective and applicable to large sample sizes making mitochondrial analysis more accessible in genetic studies. Using rigorous selection criteria, we defined and validated a custom panel of mtDNA single nucleotide polymorphisms that allows for accurate classification of European, African, and Native American mitochondrial haplogroups at broad resolution with minimal genotyping and cost. We demonstrate that Hi-MC performs well in samples of European, African, and Native American ancestries, and that Hi-MC performs comparably to a commonly used classifier. Implementation as a software package in R enables users to download and run the program locally, grants greater flexibility in the number of samples that can be run, and allows for easy expansion in future revisions. Hi-MC is available in the CRAN repository and the source code is freely available at https://github.com/vserch/himc
The 2017 BFA Graduating Class Department of Visual Arts
Between the covers of this volume, you will find a myriad of stories.
When they arrive at Grenfell Campus, our visual arts students bring with them a distinct set of experiences. During their time here, these experiences colour their work and studies, their perceptions and their realities. Sightlines reveals just a small window into this amalgam of past and present experiences and insights. The fourth-year catalogue is the product of vision, innovation and expectation
A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma
BACKGROUND
ZFTA-RELA (formerly known as c11orf-RELA) fused supratentorial ependymoma (ZFTAfus ST-EPN) has been recognized as a novel entity in the 2016 WHO classification of CNS tumors and further defined in the recent 2021 edition. ZFTAfus ST-EPN was reported to portend poorer prognosis when compared to its counterpart, YAP1 ST-EPN in some previously published series. The aim of this study was to determine the treatment outcome of molecularly confirmed and conventionally treated ZFTAfus ST-EPN patients treated in multiple institutions.
METHODS
We conducted a retrospective analysis of all pediatric patients with molecularly confirmed ZFTAfus ST-EPN patients treated in multiple institutions in 5 different countries (Australia, Canada, Germany, Switzerland, and Czechia). Survival outcomes were analyzed and correlated with clinical characteristics and treatment approaches.
RESULTS
A total of 108 patients were collated from multiple institutions in 5 different countries across three continents. We found across the entire cohort that the 5- and 10-year PFS were 65% and 63%, respectively. The 5- and 10-year OS of this cohort of patients were 87% and 73%. The rates of gross total resection (GTR) were high with 84 out of 108 (77.8%) patients achieving GTR. The vast majority of patients also received post-operative radiotherapy, 98 out of 108 (90.7%). Chemotherapy did not appear to provide any survival benefit in our patient cohort.
CONCLUSION
This is the largest study to date of contemporaneously treated molecularly confirmed ZFTAfus ST-EPN patients which identified markedly improved survival outcomes compared to previously published series. This study also re-emphasizes the importance of maximal surgical resection in achieving optimal outcomes in pediatric patients with supratentorial ependymoma
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