Evaluating the potential of immediate funds transfer for general-purpose payments in the United States

Immediate funds transfer (IFT) is a convenient, certain, secure, and low-cost means of electronically transferring money between bank accounts with no or minimal delay in receivers’ receipt and use of funds. Yet IFT is not widely available in the U.S. This article summarizes discussions on the potential for IFT in the U.S. held at the Symposium on Immediate Funds Transfer for General-Purpose Payments, sponsored by the Federal Reserve Bank of Chicago, on September 7, 2011.Payment systems

Tryptophan and ATTO 590: Mutual Fluorescence Quenching and Exciplex Formation

Investigation of fluorescence quenching of probes, such as ATTO dyes, is becoming an increasingly important topic owing to the use of these dyes in super-resolution microscopies and in single-molecule studies. Photoinduced electron transfer is their most important nonradiative pathway. Because of the increasing frequency of the use of ATTO and related dyes to investigate biological systems, studies are presented for inter- and intramolecular quenching of ATTO 590 with tryptophan. In order to examine intramolecular quenching, an ATTO 590–tryptophan conjugate was synthesized. It was determined that tryptophan is efficiently quenching ATTO 590 fluorescence by excited-state charge transfer and two charge transfer complexes are forming. In addition, it was discovered that an exciplex (whose lifetime is 5.6 ns) can be formed between tryptophan and ATTO 590, and it is suggested that the possibility of such exciplex formation should be taken into account when protein fluorescence is monitored in a system tagged with ATTO dyes

Genome sequence of a gammaherpesvirus from a common bottlenose dolphin (Tursiops truncatus)

A herpesvirus genome was sequenced directly from a biopsy specimen of a rectal lesion from a female common bottlenose dolphin. This genome sequence comprises a unique region (161,235 bp) flanked by multiple copies of a terminal repeat (4,431 bp) and contains 72 putative genes. The virus was named common bottlenose dolphin gammaherpesvirus 1

Investigation of Post-Consumer Regrind Content in Polyethylene and Polypropylene for Consumer Packaging Applications

With the rise of plastics products in waste streams, both consumer products companies and consumers are looking for greener methods to produce the same products with less of a carbon footprint. One way of achieving these goals is to include recycled plastic into consumer goods. These recycled greener alternatives provide many of the same benefits of virgin plastic material. The goal of this project was to determine what, if any, differences are there between virgin resins and resins that contain post-consumer recycled content (PCR). Control and experimental resins were obtained and injection molded to create samples for analysis. Control resins were Ineos H05A-00 Polypropylene Homopolymer and Marlex 9012 High-Density Polyethylene. Experimental resins included Plastic Bank SDS clear polypropylene (Social Plastic), KWR-621 Post Consumer Recycled FDA Polypropylene Resin, and KW Post-Consumer Recycled Polyethylene Resins: KWR 102 BM High-Density Polyethylene and KWR 101 150 Natural High-Density Polyethylene. Samples underwent thermal testing by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) to determine key thermal transition and material degradation temperatures to compare each of the experimental materials to the virgin resins. Mechanical testing included tensile testing and Izod impact testing to determine the mechanical strength of each experimental materials to compare to the virgin resins. Melt flow was performed to determine the rheological properties of the virgin and post-consumer recycled (PCR) resins in the melt

Theodore Wells Cousens Correspondence

Entries include brief biographical information, a newspaper review clipping, and typed letters with biographical information on Gaston, Snow, Rice & Boyd stationery

HE AMOT FAMILY OF PROTEINS BINDS AND ACTIVATES NEDD4 FAMILY LIGASES TO PROMOTE THE UBIQUITINATION OF LATS AND YAP

poster abstractAmot adaptor proteins bind and integrate signaling that controls cell po-larity and growth. All three Amot family members (Amot, AmotL1 and AmotL2) directly bind YAP; a transcriptional co-activator that controls the expression of genes involved in organ homeostasis and cell growth. Preven-tion of nuclear accumulation of YAP by either sequestration or degradation in the cytosol abolishes its transcriptional functions and is a major mechanism for growth arrest in response to cellular differentiation. This is mainly thought to be regulated by phosphorylation of YAP by the Hippo kinases LATS1/2. Recently, binding by the Amot proteins was also found to inhibit YAP by sequestering it in the cytosol through both LATS dependent and in-dependent mechanisms. This study identifies a novel mechanism whereby Amot proteins control YAP activation in a Hippo independent mechanism by coupling it to ubiquitination by Nedd4 family ligases. Amot proteins mediate the coupling of Nedd4 ligases with YAP by simultaneously binding both pro-teins via multiple PY motifs that are recognized by WW domains in both YAP and Nedd4. Binding of Nedd4 by Amot is also shown to relieve the auto-inhibition of its ligase activity. This may be a direct consequence of binding Amot or from being re-targeted in cells by Amot proteins to endosomes. Im-portantly, Amot induced ubiquitination of YAP by Nedd4 proteins is shown to enhance the residence of YAP in the nucleus and in YAP activated transcrip-tion. Taken together our data suggest that Amot couples Nedd4 family ubiq-uitin ligases with the transcriptional co-activator YAP to drive the ubiquitination and activation of YAP

rTensor: An R Package for Multidimensional Array (Tensor) Unfolding, Multiplication, and Decomposition

rTensor is an R package designed to provide a common set of operations and decompositions for multidimensional arrays (tensors). We provide an S4 class that wraps around the base 'array' class and overloads familiar operations to users of 'array', and we provide additional functionality for tensor operations that are becoming more relevant in recent literature. We also provide a general unfolding operation, for which the k-mode unfolding and the matrix vectorization are special cases of. Finally, package rTensor implements common tensor decompositions such as canonical polyadic decomposition, Tucker decomposition, multilinear principal component analysis, t-singular value decomposition, as well as related matrix-based algorithms such as generalized low rank approximation of matrices and popular value decomposition

Moving towards a wave-resolved approach to forecasting mountain wave induced clear air turbulence

Mountain wave breaking in the lower stratosphere is one of the major causes of atmospheric turbulence encountered in commercial aviation, which in turn is the cause of most weather-related aircraft incidents. In the case of clear air turbulence (CAT), there are no visual clues and pilots are reliant on operational forecasts and reports from other aircraft. Traditionally mountain waves have been sub-grid-scale in global numerical weather prediction (NWP) models, but recent developments in NWP mean that some forecast centres (e.g. the UK Met Office) are now producing operational global forecasts that resolve mountain wave activity explicitly, allowing predictions of mountain wave induced turbulence with greater accuracy and confidence than previously possible. Using a bespoke turbulent kinetic energy diagnostic, the Met Office Unified Model (MetUM) is shown to produce useful forecasts of mountain CAT during three case studies over Greenland, and to outperform the current operational Met Office CAT prediction product (the World Area Forecast Centre (WAFC) London gridded CAT product) in doing so. In a long term, 17-month, verification, MetUM forecasts yield a turbulence prediction hit rate of 80% with an accompanying false alarm rate of under 40%. These skill scores are a considerable improvement on those reported for the mountain wave component of the WAFC product, although no direct comparison is available. The major implication of this work is that sophisticated global NWP models are now sufficiently advanced to provide skilful forecasts of mountain wave turbulence

Serial decline in lung volume parameters on computed tomography (CT) predicts outcome in idiopathic pulmonary fibrosis (IPF)

OBJECTIVES: In patients with IPF, this study aimed (i) to examine the relationship between serial change in CT parameters of lung volume and lung function, (ii) to identify the prognostic value of serial change in CT parameters of lung volume, and (iii) to define a threshold for serial change in CT markers of lung volume that optimally captures disease progression. METHODS: Serial CTs were analysed for progressive volume loss or fibrosis progression in 81 IPF patients (66 males, median age = 67 years) with concurrent forced vital capacity (FVC) (median follow-up 12 months, range 6-23 months). Serial CT measurements of volume loss comprised oblique fissure posterior retraction distance (OFPRD), aortosternal distance (ASD), lung height corrected for body habitus (LH), and automated CT-derived total lung volumes (ALV) (measured using commercially available software). Fibrosis progression was scored visually. Serial changes in CT markers and FVC were compared using regression analysis, and evaluated against mortality using Cox proportional hazards. RESULTS: There were 58 deaths (72%, median survival = 17 months). Annual % change in ALV was most significantly related to annual % change in FVC (R2 = 0.26, p < 0.0001). On multivariate analysis, annual % change in ASD predicted mortality (HR = 0.97, p < 0.001), whereas change in FVC did not. A 25% decline in annual % change in ASD best predicted mortality, superior to 10% decline in FVC and fibrosis progression. CONCLUSION: In IPF, serial decline in CT markers of lung volume and, specifically, annualised 25% reduction in aortosternal distance provides evidence of disease progression, not always identified by FVC trends or changes in fibrosis extent. KEY POINTS: • Serial decline in automated and surrogate markers of lung volume on CT corresponds to changes in FVC. • Annualised reductions in the distance between ascending aorta and posterior border of the sternum on CT predict mortality beyond annualised percentage change in FVC