Rigorous analysis of extremely asymmetrical scattering of electromagnetic waves in slanted periodic gratings

Extremely asymmetrical scattering (EAS) is a new type of Bragg scattering in thick, slanted, periodic gratings. It is realised when the scattered wave propagates parallel to the front boundary of the grating. Its most important feature is the strong resonant increase in the scattered wave amplitude compared to the amplitude of the incident wave: the smaller the grating amplitude, the larger the amplitude of the scattered wave. In this paper, rigorous numerical analysis of EAS is carried out by means of the enhanced T-matrix algorithm. This includes investigation of harmonic generation inside and outside the grating, unusually strong edge effects, fast oscillations of the incident wave amplitude in the grating, etc. Comparison with the previously developed approximate theory is carried out. In particular, it is demonstrated that the applicability conditions for the two-wave approximation in the case of EAS are noticeably more restrictive than those for the conventional Bragg scattering. At the same time, it is shown that the approximate theory is usually highly accurate in terms of description of EAS in the most interesting cases of scattering with strong resonant increase of the scattered wave amplitude. Physical explanation of the predicted effects is presented.Comment: 14 pages, 7 figures; v2: corrections to metadata and bibliographical info in preprin

The PULSAR Specialist Care protocol: a stepped-wedge cluster randomized control trial a training intervention for community mental health teams in recovery-oriented practice

Background: Recovery features strongly in Australian mental health policy; however, evidence is limited for the efficacy of recovery-oriented practice at the service level. This paper describes the Principles Unite Local Services Assisting Recovery (PULSAR) Specialist Care trial protocol for a recovery-oriented practice training intervention delivered to specialist mental health services staff. The primary aim is to evaluate whether adult consumers accessing services where staff have received the intervention report superior recovery outcomes compared to adult consumers accessing services where staff have not yet received the intervention. A qualitative sub-study aims to examine staff and consumer views on implementing recovery-oriented practice. A process evaluation sub-study aims to articulate important explanatory variables affecting the interventions rollout and outcomes. Methods: The mixed methods design incorporates a two-step stepped-wedge cluster randomized controlled trial (cRCT) examining cross-sectional data from three phases, and nested qualitative and process evaluation sub-studies. Participating specialist mental health care services in Melbourne, Victoria are divided into 14 clusters with half randomly allocated to receive the staff training in year one and half in year two. Research participants are consumers aged 18-75 years who attended the cluster within a previous three-month period either at baseline, 12 (step 1) or 24 months (step 2). In the two nested sub-studies, participation extends to cluster staff. The primary outcome is the Questionnaire about the Process of Recovery collected from 756 consumers (252 each at baseline, step 1, step 2). Secondary and other outcomes measuring well-being, service satisfaction and health economic impact are collected from a subset of 252 consumers (63 at baseline; 126 at step 1; 63 at step 2) via interviews. Interview based longitudinal data are also collected 12 months apart from 88 consumers with a psychotic disorder diagnosis (44 at baseline, step 1; 44 at step 1, step 2). cRCT data will be analyzed using multilevel mixed-effects modelling to account for clustering and some repeated measures, supplemented by thematic analysis of qualitative interview data. The process evaluation will draw on qualitative, quantitative and documentary data. Discussion: Findings will provide an evidence-base for the continued transformation of Australian mental health service frameworks toward recovery

Integrins as therapeutic targets: lessons and opportunities.

The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function. The identification of key roles for integrins in a diverse range of diseases, including cancer, infection, thrombosis and autoimmune disorders, has revealed their substantial potential as therapeutic targets. However, so far, pharmacological inhibitors for only three integrins have received marketing approval. This article discusses the structure and function of integrins, their roles in disease and the chequered history of the approved integrin antagonists. Recent advances in the understanding of integrin function, ligand interaction and signalling pathways suggest novel strategies for inhibiting integrin function that could help harness their full potential as therapeutic targets

Principles of genetic circuit design

Cells navigate environments, communicate and build complex patterns by initiating gene expression in response to specific signals. Engineers seek to harness this capability to program cells to perform tasks or create chemicals and materials that match the complexity seen in nature. This Review describes new tools that aid the construction of genetic circuits. Circuit dynamics can be influenced by the choice of regulators and changed with expression 'tuning knobs'. We collate the failure modes encountered when assembling circuits, quantify their impact on performance and review mitigation efforts. Finally, we discuss the constraints that arise from circuits having to operate within a living cell. Collectively, better tools, well-characterized parts and a comprehensive understanding of how to compose circuits are leading to a breakthrough in the ability to program living cells for advanced applications, from living therapeutics to the atomic manufacturing of functional materials.National Institute of General Medical Sciences (U.S.) (Grant P50 GM098792)National Institute of General Medical Sciences (U.S.) (Grant R01 GM095765)National Science Foundation (U.S.). Synthetic Biology Engineering Research Center (EEC0540879)Life Technologies, Inc. (A114510)National Science Foundation (U.S.). Graduate Research FellowshipUnited States. Office of Naval Research. Multidisciplinary University Research Initiative (Grant 4500000552

Modified coupled-mode model for thermally chirped polymer Bragg gratings

A modified coupled-mode (CM) model is proposed for the optical behavior of thermally chirped Bragg gratings. The model accounts for the axial gradient in the modulation wavenumber, which has been ignored in the classical CM model. The model is used to characterize the optical behavior of a polymethyl methacrylate- based polymer Bragg grating subjected to nonisothermal conditions. The validity of the proposed method is verified by comparing the results of the modified CM model with those obtained from the exact numerical solution