The Boltzmann Equation in Scalar Field Theory

We derive the classical transport equation, in scalar field theory with a V(phi) interaction, from the equation of motion for the quantum field. We obtain a very simple, but iterative, expression for the effective action which generates all the n-point Green functions in the high-temperature limit. An explicit closed form is given in the static case.Comment: 10 pages, using RevTeX (corrected TeX misprints

High-temperature QCD and the classical Boltzmann equation in curved spacetime

It has been shown that the high-temperature limit of perturbative thermal QCD is easily obtained from the Boltzmann transport equation for `classical' coloured particles. We generalize this treatment to curved space-time. We are thus able to construct the effective stress-energy tensor. We give a construction for an effective action. As an example of the convenience of the Boltzmann method, we derive the high-temperature 3-graviton function. We discuss the static case.Comment: uuencoded gz-compressed .dvi fil

Energy and pressure densities of a hot quark-gluon plasma

We calculate the energy and hydrostatic pressure densities of a hot quark-gluon plasma in thermal equilibrium through diagrammatic analyses of the statistical average, $\langle \Theta_{\mu \nu} \rangle$, of the energy-momentum-tensor operator $\Theta_{\mu \nu}$. To leading order at high temperature, the energy density of the long wave length modes is consistently extracted by applying the hard-thermal-loop resummation scheme to the operator-inserted no-leg thermal amplitudes $\langle \Theta_{\mu \nu} \rangle$. We find that, for the long wave length gluons, the energy density, being positive, is tremendously enhanced as compared to the noninteracting case, while, for the quarks, no noticeable deviation from the noninteracting case is found.Comment: 33 pages. Figures are not include

Metabolome-Informed Microbiome Analysis Refines Metadata Classifications and Reveals Unexpected Medication Transfer in Captive Cheetahs.

Even high-quality collection and reporting of study metadata in microbiome studies can lead to various forms of inadvertently missing or mischaracterized information that can alter the interpretation or outcome of the studies, especially with nonmodel organisms. Metabolomic profiling of fecal microbiome samples can provide empirical insight into unanticipated confounding factors that are not possible to obtain even from detailed care records. We illustrate this point using data from cheetahs from the San Diego Zoo Safari Park. The metabolomic characterization indicated that one cheetah had to be moved from the non-antibiotic-exposed group to the antibiotic-exposed group. The detection of the antibiotic in this second cheetah was likely due to grooming interactions with the cheetah that was administered antibiotics. Similarly, because transit time for stool is variable, fecal samples within the first few days of antibiotic prescription do not all contain detected antibiotics, and the microbiome is not yet affected. These insights significantly altered the way the samples were grouped for analysis (antibiotic versus no antibiotic) and the subsequent understanding of the effect of the antibiotics on the cheetah microbiome. Metabolomics also revealed information about numerous other medications and provided unexpected dietary insights that in turn improved our understanding of the molecular patterns on the impact on the community microbial structure. These results suggest that untargeted metabolomic data provide empirical evidence to correct records and aid in the monitoring of the health of nonmodel organisms in captivity, although we also expect that these methods may be appropriate for other social animals, such as cats.IMPORTANCE Metabolome-informed analyses can enhance omics studies by enabling the correct partitioning of samples by identifying hidden confounders inadvertently misrepresented or omitted from carefully curated metadata. We demonstrate here the utility of metabolomics in a study characterizing the microbiome associated with liver disease in cheetahs. Metabolome-informed reinterpretation of metagenome and metabolome profiles factored in an unexpected transfer of antibiotics, preventing misinterpretation of the data. Our work suggests that untargeted metabolomics can be used to verify, augment, and correct sample metadata to support improved grouping of sample data for microbiome analyses, here for nonmodel organisms in captivity. However, the techniques also suggest a path forward for correcting clinical information in microbiome studies more broadly to enable higher-precision analyses

Effective Action of Spontaneously Broken Gauge Theories

The effective action of a Higgs theory should be gauge-invariant. However, the quantum and/or thermal contributions to the effective potential seem to be gauge-dependent, posing a problem for its physical interpretation. In this paper, we identify the source of the problem and argue that in a Higgs theory, perturbative contributions should be evaluated with the Higgs fields in the polar basis, not in the Cartesian basis. Formally, this observation can be made from the derivation of the Higgs theorem, which we provide. We show explicitly that, properly defined, the effective action for the Abelian Higgs theory is gauge invariant to all orders in perturbation expansion when evaluated in the covariant gauge in the polar basis. In particular, the effective potential is gauge invariant. We also show the equivalence between the calculations in the covariant gauge in the polar basis and the unitary gauge. These points are illustrated explicitly with the one-loop calculations of the effective action. With a field redefinition, we obtain the physical effective potential. The SU(2) non-Abelian case is also discussed.Comment: Expanded version, 32 pages, figures produced by LaTeX, plain LaTe

Hard Loop Approach to Anisotropic Systems

Anisotropic systems of quarks and gluons, which at least for sufficiently short space-time intervals can be treated as homogeneous and static, are considered. The gluon polarization tensor of such a system is explicitly computed within the semiclassical kinetic and Hard Loop diagrammatic theories. The equivalence of the two approaches is demonstrated. The quark self energy is computed as well, and finally, the dispersion relations of quarks and gluons in the anisotropic medium are discussed.Comment: 10 pages, revised to appear in Phys. Rev.

Magnetic Screening at Finite Temperature

It is shown that at finite temperature and in the presence of magnetic sources magnetic fields are screened. This is proven within the framework of classical transport theory both for the Abelian and non-Abelian plasmas. Magnetic screening arises in this formalism as a consequence of polarization effects occurring in the plasmas, and it is proportional to the inverse of the gauge coupling constant. It is then discussed whether this mechanism could be relevant in realistic quantum gauge field theories, such as QCD.Comment: 21 pages, RevTex; rewritten discussion, misleading sentences have been eliminated, results unchange

Disentangling the Imaginary-Time Formalism at Finite Temperature

We rewrite the imaginary-time formalism of finite temperature field theory in a form that all graphs used in calculating physical processes do not have any loops. Any production of a particle from a heat bath which is itself not thermalized or the decay and absorption of a similar particle in the bath is expressed entirely in terms of the sum of particle interaction processes. These are themselves very general in meaning. They can be straight forward interactions or the more subtle and less well-known purely interference processes that do not have a counter part in the vacuum.Comment: 14 pages revtex style, 20 embedded EPS figures, added discussion of the connection with the real-time formalism + reference

Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding

Secretory leucoprotease inhibitor (SLPI) is a nonglycosylated protein produced by epithelial cells. In addition to its antiprotease activity, SLPI has been shown to exhibit antiinflammatory properties, including down-regulation of tumor necrosis factor α expression by lipopolysaccharide (LPS) in macrophages and inhibition of nuclear factor (NF)-κB activation in a rat model of acute lung injury. We have previously shown that SLPI can inhibit LPS-induced NF-κB activation in monocytic cells by inhibiting degradation of IκBα without affecting the LPS-induced phosphorylation and ubiquitination of IκBα. Here, we present evidence to show that upon incubation with peripheral blood monocytes (PBMs) and the U937 monocytic cell line, SLPI enters the cells, becoming rapidly localized to the cytoplasm and nucleus, and affects NF-κB activation by binding directly to NF-κB binding sites in a site-specific manner. SLPI can also prevent p65 interaction with the NF-κB consensus region at concentrations commensurate with the physiological nuclear levels of SLPI and p65. We also demonstrate the presence of SLPI in nuclear fractions of PBMs and alveolar macrophages from individuals with cystic fibrosis and community-acquired pneumonia. Therefore, SLPI inhibition of NF-κB activation is mediated, in part, by competitive binding to the NF-κB consensus-binding site

The double burden of age and disease on cognition and quality of life in bipolar disorder

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108337/1/gps4084.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/108337/2/gps4084-sup-0002-TableS1.pd