Fluorogene ATP-Analoga zur Detektion von ATP-Verbrauch: Beobachtung der Aktivierung von Ubiquitin in Echtzeit

publishe

Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time

Many enzymes use ATP in signal-transducing processes or as an energy source. New fluorogenic ATP analogues signal ATP consumption by ubiquitin-like protein-activating enzymes in real time. Thus the inhibition and stimulation of these ATP-processing enzymes can be studied without auxiliary enzymes and reagents. beta-Lapachone was identified as an inhibitor of the ubiquitin-activating enzyme UBA1 (see scheme; A=acceptor, D=donor)

Hand over fist: a chronicle of Cold War photography

Group Material's Timeline: The Chronicle of US Invention in Latin and Central America (1984) at P.S.1's Center for Contemporary Art explored the framing devices of installation art and photography in tandem, as a means of reconfiguring the distribution of the sensible at the height of the Cold War. In response to escalating crisis (including continuous Central Intelligence Agency operations being carried out in Nicaragua and El Salvador), this activist project employed postmodern strategies such as appropriation, pastiche and a resistance to conclusiveness in order to suggest provocative and unexpected dialogues between disparate artworks and artefacts across time and geopolitical difference. Artists ranging from Richard Prince and Barbara Kruger to John Heartfield, Tina Modotti and Arellano Bolivar, among others, come together as signs of political and aesthetic conflict, as networks of visual culture that complicate dominant narratives of spatial and temporal reality during the Cold War era. Closer analysis of such works reveals historical ruptures alongside continuities, relayed by official government policy, mass media and the art world more broadly. By excavating a long-standing history of conflict, Timeline addresses the stakes of the ownership of meaning itself in the mid-1980s, with implications regarding art production and politics for generations to come