Instability and multiple steady states in a meridional-plane model of the thermohaline circulation

A meridional-plane model of the thermohaline circulation with a simple friction force and advection and vertical diffusion of the T-S field has been used to demonstrate the instability and existence of multiple steady states associated with “mixed” T-S boundary conditions (specified temperature, flux condition for salinity). With forcing and geometry symmetric to the equator, the symmetric solution was found to be unstable to infinitesimal perturbations, and an asymmetric pole-to-pole circulation was the end-result in all cases. The structure obtained for the meridional-plane stream function and for the poleward heat flux are in qualitative agreement with those obtained by Bryan (1986). Convective overturning caused by static instability was not found to be essential for the transition to the asymmetric steady state. The study suggests that certain aspects of the ocean circulation, in particular those related to the ocean climate, may be profitably explored by use of two-dimensional, zonally averaged models

Reduced leakage current in Josephson tunnel junctions with codeposited barriers

Josephson junctions were fabricated using two different methods of barrier formation. The trilayers employed were Nb/Al-AlOx/Nb on sapphire, where the first two layers were epitaxial. The oxide barrier was formed either by exposing the Al surface to O2 or by codepositing Al in an O2 background. The codeposition process yielded junctions that showed the theoretically predicted subgap current and no measurable shunt conductance. In contrast, devices with barriers formed by thermal oxidation showed a small shunt conductance in addition to the predicted subgap current.Comment: 3 pages, 4 figure

System of elastic hard spheres which mimics the transport properties of a granular gas

The prototype model of a fluidized granular system is a gas of inelastic hard spheres (IHS) with a constant coefficient of normal restitution $\alpha$. Using a kinetic theory description we investigate the two basic ingredients that a model of elastic hard spheres (EHS) must have in order to mimic the most relevant transport properties of the underlying IHS gas. First, the EHS gas is assumed to be subject to the action of an effective drag force with a friction constant equal to half the cooling rate of the IHS gas, the latter being evaluated in the local equilibrium approximation for simplicity. Second, the collision rate of the EHS gas is reduced by a factor $(1+\alpha)/2$, relative to that of the IHS gas. Comparison between the respective Navier-Stokes transport coefficients shows that the EHS model reproduces almost perfectly the self-diffusion coefficient and reasonably well the two transport coefficients defining the heat flux, the shear viscosity being reproduced within a deviation less than 14% (for $\alpha\geq 0.5$). Moreover, the EHS model is seen to agree with the fundamental collision integrals of inelastic mixtures and dense gases. The approximate equivalence between IHS and EHS is used to propose kinetic models for inelastic collisions as simple extensions of known kinetic models for elastic collisionsComment: 20 pages; 6 figures; change of title; few minor changes; accepted for publication in PR

Photoelectron angular distributions in photodetachment from P-

The angular distributions of electrons ejected in laser photodetachment of the P- ion have been studied in the photon energy range of 0.95-3.28 eV using a photoelectron spectrometer designed to accommodate a source consisting of collinearly overlapping photon and negative ion beams. We observe the value of the asymmetry parameter β starting at zero near the threshold, falling to almost -1 about 0.5 eV above the threshold and eventually rising to a positive value. The experimental data has been fitted to a simplified model of the Cooper-Zare formula which yields a qualitative understanding of the quantum interference between the outgoing s and d waves representing the free electron. The present results are also compared with previous results for other elements involving p-electron photodetachment

Migraine and gastrointestinal disorders in middle and old age: A UK Biobank study

Introduction: Migraine is a prevalent condition causing a substantial level of disability worldwide. Despite this, the pathophysiological mechanisms are not fully understood. Migraine often co-occurs with gastrointestinal disorders, but the direction of a potential causal link is unclear. The aim of this project was to investigate the associations between migraine and several gastrointestinal disorders in the same cohort in order to determine the relative strengths of these associations. Methods: This cross-sectional study examined whether migraine is associated with irritable bowel syndrome (IBS), peptic ulcers, Helicobacter pylori (HP) infections, celiac disease, Crohn's disease and ulcerative colitis. Baseline data covering 489,753 UK Biobank participants (migraine group: n = 14,180) were analyzed using Pearson's chi-square tests and adjusted binary logistic regression models. Results: Migraine was significantly associated with IBS (odds ratio [OR] 2.24, 95% confidence interval [CI] 2.08–2.40, p <.001) and peptic ulcers (OR 1.55, 95% CI 1.35–1.77, p <.001). Migraine was not associated with HP infection (OR 1.34, 95% CI 1.04–1.73, p =.024), celiac disease (OR 1.29, 95% CI 1.04–1.60, p =.023), Crohn's disease (OR 1.08, 95% CI 0.80–1.45, p =.617) or ulcerative colitis (OR 1.00, 95% CI 0.79–1.27, p =.979) after adjusting for multiple testing. Conclusions: Migraine was associated with IBS and peptic ulcers in this large population-based cohort. The associations with HP infection, celiac disease, Crohn's disease, and ulcerative colitis did not reach significance, suggesting a weaker link between migraine and autoimmune gastrointestinal conditions or HP infection

T-cell intracellular antigens in health and disease

T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the nucleus as regulators of transcription and pre-mRNA splicing. In the cytoplasm, TIA1 and TIAR regulate and/or modulate the location, stability and/or translation of mRNAs. As knowledge of the different genes regulated by these proteins and the cellular/biological programs in which they are involved increases, it is evident that these antigens are key players in human physiology and pathology. This review will discuss the latest developments in the field, with physiopathological relevance, that point to novel roles for these regulators in the molecular and cell biology of higher eukaryotes.Ministry Economic Affairs and Competitiveness through FEDER funds (BFU2008–00354, BFU2011–29653 and BFU2014–57735-R). The CBMSO receives an institutional grant from Fundación Ramón Areces.Peer Reviewe

Causal Relativistic Fluid Dynamics

We derive causal relativistic fluid dynamical equations from the relaxation model of kinetic theory as in a procedure previously applied in the case of non-relativistic rarefied gases. By treating space and time on an equal footing and avoiding the iterative steps of the conventional Chapman-Enskog --- CE---method, we are able to derive causal equations in the first order of the expansion in terms of the mean flight time of the particles. This is in contrast to what is found using the CE approach. We illustrate the general results with the example of a gas of identical ultrarelativistic particles such as photons under the assumptions of homogeneity and isotropy. When we couple the fluid dynamical equations to Einstein's equation we find, in addition to the geometry-driven expanding solution of the FRW model, a second, matter-driven nonequilibrium solution to the equations. In only the second solution, entropy is produced at a significant rate.Comment: 23 pages (CQG, in press