Jewish History of Small-Town America

Lee Shai Weissbach, author and professor of history, University of Louisville, KY.https://digitalcommons.fairfield.edu/bennettcenter-posters/1311/thumbnail.jp

Collaborating With Writing Centers on Interdisciplinary Peer Tutor Training to Improve Writing Support for Engineering Students

Introduction: Faculty members have little time and usually lack expertise to provide writing feedback on lab reports. Sending students to a writing center, an existing resource on virtually all college campuses, could fill that gap. However, the majority of peer writing tutors are in nontechnical majors, and little research exists on training them to provide support for engineering students. Research question: Can peer writing tutors without technical backgrounds be trained to provide effective feedback to engineering students? About the case: Previously, sending students to the writing center was ineffective. The students did not see the value, and the tutors did not feel capable of providing feedback to them. To remedy this situation, an interdisciplinary training method was developed collaboratively by an engineering professor and the writing center director. Situating the case: Researchers have suggested that effective writing center help for engineering students is possible, and the authors have designed an interdisciplinary training method that has produced positive results. Supporting literature includes the use of generalist tutors, writing in the disciplines, genre theory, and knowledge transfer. Methods/approach: This was a three-year experiential project conducted in a junior-level engineering course. The assignment, a lab report, remained the same. Qualitative and quantitative data were collected from students and tutors. Results/discussion: Tutor feedback and student satisfaction significantly improved. However, a few students who were satisfied overall still expressed interest in having their reports reviewed by a tutor with a technical background. Conclusions: Interdisciplinary tutor training can improve the feedback of peer writing tutors, providing support for faculty efforts to improve student writing. The method requires minimal faculty time and capitalizes on existing resources

Industrial Sponsor Perspective On Leveraging Capstone Design Projects To Enhance Their Business

Capstone design projects have become commonplace among engineering and engineering technology programs.  These projects are valuable tools when assessing students, as they require students to work in teams, communicate effectively, and demonstrate technical competency.  The use of industrial sponsors enhances these projects by giving these projects more of a “real world” feel.  Most of the research into capstone design projects focuses on student learning as well as the overall design process.  However, very little research has been performed from the perspective of the industrial sponsor.  In this paper, an industrial sponsor who has sponsored several large-scale capstone design projects presents their perspective on working with students on these projects.  These projects serve as training systems for their existing employees and clients, and offer the sponsor the opportunity to evaluate the students as prospective future employees

Improved radiative corrections for (e,e'p) experiments - A novel approach to multi-photon bremsstrahlung

Radiative processes lead to important corrections to (e,e'p) experiments. While radiative corrections can be calculated exactly in QED and to a good accuracy also including hadronic corrections, these corrections cannot be included into data analyses to arbitrary orders exactly. Nevertheless consideration of multi-photon bremsstrahlung above the low-energy cut-off is important for many (e,e'p) experiments. To date, higher-order bremsstrahlung effects concerning electron scattering experiments have been implemented approximately by employing the soft-photon approximation (SPA). In this paper we propose a novel approach to multi-photon emission which partially removes the SPA from (e,e'p) experiments. In this combined approach one hard photon is treated exactly; and additional softer bremsstrahlung photons are taken into account resorting to the soft-photon approximation. This partial removal of the soft-photon approximation is shown to be relevant for the missing-energy distribution for several kinematic settings at MAMI and TJNAF energies.Comment: 10 pages, 21 figure

Quasi Self-Excited DFIG-Based Wind Energy Conversion System

This article introduces a new configuration of the doubly-fed induction generator (DFIG) based wind energy conversion system (WECS) employing only a reduced-size rotor side converter (RSC) in tandem with a supercapacitor. In the proposed structure, the grid side converter (GSC) utilized in conventional DFIG-based WECSs is successfully eliminated. This is accomplished by employing the hydraulic transmission system (HTS) as a continuously variable and shaft decoupling transmission unit. This transforms the conventional constant-ratio drives by providing an opportunity to control the power flow through the generator's rotor circuit regardless of the wind turbine's shaft speed. This feature of HTS can be utilized to control the RSC power and ultimately regulate the supercapacitor voltage without a need for GSC. The proposed system is investigated and simulated in MATLAB Simulink at various wind speeds to validate the results and demonstrate the dynamic performance of the system

Improved radiative corrections and proton charge form factor from the Rosenbluth separation technique

We investigate whether the apparent discrepancy between proton electric form factor from measurements using the Rosenbluth separation technique and polarization transfer method is due to the standard approximations employed in radiative correction procedures. Inaccuracies due to both the peaking approximation and the soft-photon approximation have been removed in our simulation approach. In contrast to results from (e,e'p) experiments, we find them in this case to be too small to explain the discrepancy.Comment: 6 pages, 3 figure

BK polyomavirus microRNA levels in exosomes are modulated by non-coding control region activity and down-regulate viral replication when delivered to non-infected cells prior to infection

In immunosuppressed patients, BKPyV-variants emerge carrying rearranged non-coding control-regions (rr-NCCRs) that increase early viral gene region (EVGR) expression and replication capacity. BKPyV also encodes microRNAs, which have been reported to downregulate EVGR-encoded large T-antigen transcripts, to decrease viral replication in infected cells and to be secreted in exosomes. To investigate the interplay of NCCR and microRNAs, we compared archetype- and rr-NCCR-BKPyV infection in cell culture. We found that laboratory and clinical rr-NCCR-BKPyV-strains show higher replication rates but significantly lower microRNA levels than archetype virus intracellularly and in exosomes. To investigate whether rr-NCCR or increased EVGR activity modulated microRNA levels, we examined the (sp1-4)NCCR-BKPyV, which has an archetype NCCR-architecture but shows increased EVGR expression due to point mutations inactivating one Sp1 binding site. We found that microRNA levels following (sp1-4)NCCR-BKPyV infection were as low as in rr-NCCR-variants. Thus, NCCR rearrangements are not required for lower miRNA levels. Accordingly, Sp1 siRNA knock-down decreased microRNA levels in archetype BKPyV infection but had no effect on (sp1-4)- or rr-NCCR-BKPyV. However, rr-NCCR-BKPyV replication was downregulated by exosome preparations carrying BKPyV-microRNA prior to infection. To explore the potential relevance in humans, urine samples from 12 natalizumab-treated multiple sclerosis patients were analysed. In 7 patients, rr-NCCR-BKPyV were detected showing high urine BKPyV loads but low microRNAs levels, whereas the opposite was seen in 5 patients with archetype BKPyV. We discuss the results in a dynamic model of BKPyV replication according to NCCR activity and exosome regulation, which integrates immune selection pressure, spread to new host cells and rr-NCCR emergence

Relationship of Genotype, Phenotype, and Treatment in Dopa-Responsive Dystonia: MDSGene Review

Background Pathogenic variants in 5 genes (GCH1, TH, PTS, SPR, and QDPR), involved in dopamine/tetrahydrobiopterin biosynthesis or recycling, have been linked to Dopa-responsive dystonia (DRD). Diagnosis and treatment are often delayed due to high between- and within-group variability. Objectives Comprehensively analyzed individual genotype, phenotype, treatment response, and biochemistry information. Methods 734 DRD patients and 151 asymptomatic GCH1 mutation carriers were included using an MDSGene systematic literature review and an automated classification approach to distinguish between different forms of monogenic DRDs. Results Whereas dystonia, L-Dopa responsiveness, early age at onset, and diurnal fluctuations were identified as red flags, parkinsonism without dystonia was rarely reported (11%) and combined with dystonia in only 18% of patients. While sex was equally distributed in autosomal recessive DRD, there was female predominance in autosomal dominant DYT/PARK-GCH1 patients accompanied by a lower median age at onset and more dystonia in females compared to males. Accordingly, the majority of asymptomatic heterozygous GCH1 mutation carriers (>8 years of age) were males. Multiple other subgroup-specific characteristics were identified, showing high accuracy in the automated classification approach: Seizures and microcephaly were mostly seen in DYT/PARK-PTS, autonomic symptoms appeared commonly in DYT/PARK-TH and DYT/PARK-PTS, and sleep disorders and oculogyric crises in DYT/PARK-SPR. Biochemically, homovanillic acid and 5-hydroxyindoleacetic acid in CSF were reduced in most DRDs, but neopterin and biopterin were increased only in DYT/PARK-PTS and DYT/PARK-SPR. Hyperphenylalaninemia was seen in DYT/PARK-PTS, DYT/PARK-QDPR, and rarely reported in autosomal recessive DYT/PARK-GCH1. Conclusions Our indicators will help to specify diagnosis and accelerate start of treatment. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Societ

Operator Method for Nonperturbative Calculation of the Thermodynamic Values in Quantum Statistics. Diatomic Molecular Gas

Operator method and cumulant expansion are used for nonperturbative calculation of the partition function and the free energy in quantum statistics. It is shown for Boltzmann diatomic molecular gas with some model intermolecular potentials that the zeroth order approximation of the proposed method interpolates the thermodynamic values with rather good accuracy in the entire range of both the Hamiltonian parameters and temperature. The systematic procedure for calculation of the corrections to the zeroth order approximation is also considered.Comment: 22 pages, 7 Postscript figures, accepted for publication in Journal of Physics